Protein Alignment Sec71 and GEA1

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: NP_012565.1
• Gene: GEA1 / 853488
• SGDID: S000003792
• Length: 1408
• Species: Saccharomyces cerevisiae
• Alignment Length: 1696
• Identity: 355/1696 - (20%)
• Similarity: 625/1696 - (36%)
• Gaps: 488/1696 - (28%)

  Fly    35 KKSCDSALEQIKAELISAGQ----------IAEGNELPCAA-----------LPLPKNDAASI-- 76
            |:|.|.:...: |.|:..|.          :...:.||.::           |.|..||...:
Yeast    31 KQSRDKSQTSV-AALLGGGSDIFLSQSDSFVDSFHNLPTSSYHDPLISGLVQLRLKINDLKGLDS 94

  Fly    77 INAETYFLPF--ELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGC 139
            :||.....||  .::..|.|......|||.|||:.....:..:..|.    .:.:...||.:..|
Yeast    95 LNALELLKPFLEIVSASSVSGYTTSLALDSLQKVFTLKIINKTFNDI----QIAVRETVVALTHC 155

  Fly   140 -FSGPQ--TDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQT------- 194
             |...:  :|::|.|:::..|..::||...:....|::      ||:..::.:|...|
Yeast   156 RFEASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTII------YDVLQTTLSLACNTQRSEVLR 214

  Fly   195 -TARATLTQMLNVIFARMENQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDS---DEVIASELL 255
             ||..|:..:...:|.:::    .|.||..  |...|:        :||..|:   |::|.:
Yeast   215 KTAEVTIAGITVKLFTKLK----LLDPPTK--TEKYIN--------DESYTDNNLKDDIIGT--- 262

  Fly   256 AEIISAAYNEAMKDQESVGEPEPTLNGNDYSSHSDHDSVE-------------LHSENDAVVTAK 307
                                   |.:.||.||..|..:|.             ...|||.....|
Yeast   263 -----------------------TTSDNDLSSTDDDSAVADDNKNEKPVQQVIREQENDEETAEK 304

  Fly   308 FTHILQKDAFLVFRALCKLSMK-PLPDGHPDPKSHELRSKVLSLHLLLLILQNAG---------- 361
            ..::.......|.:....|.:. .:|:..   ..|...:..|||.|:...::.:|
Yeast   305 AENVEPNYGITVIKDYLGLLLSLVMPENR---MKHTTSAMKLSLQLINAAIEISGDKFPLYPRLF 366

  Fly   362 -----PVFRSNEMFIMAIKQYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFK 421
                 |:|:|....|.:..||              .:.:.:|.:|.:|:.....:|..|||:..:
Yeast   367 SLISDPIFKSVLFIIQSSTQY--------------SLLQATLQLFTSLVVILGDYLPMQIELTLR 417

  Fly   422 EIFLNILEANSSSFEHKWMVIQALTRICADAQSV---------VDIYVNYDCDFSAANLFERLVN 477
            .|| .|||..:.|.:.......|:..:..:..|:         :.::||:||:...::|....:.
Yeast   418 RIF-EILEDTTISGDVSKQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIK 481

  Fly   478 DLSKIAQGRQALELGAN--PMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPT 540
            :|:|.:....|:....|  |:           ||..:|..:.....||
Yeast   482 ELTKFSLPAAAVNTSNNIPPI-----------CLEGVLSLIENIYNDL----------------- 518

  Fly   541 STEQDQADTTIQTMHSGSSHSLNSNQEQLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQ 605
             ...|:|:..             .||:::    :.|::|..:.|.: ..:|.||.|.:||:|.|.
Yeast   519 -QRFDRAEFV-------------KNQKEI----DILKQRDRKTEFI-LCVETFNEKAKKGIQMLI 564

  Fly   606 EKQLLGATCG-DIARWLH-EDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFL 668
            ||..:.:... |||.:|. .:.||:|..||..:  .|.....::..:||.|||:.:.|..|:|.|
Yeast   565 EKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLL--CDPKKTSLLKEFIDLFDFKGLRVDEAIRIL 627

  Fly   669 LEGFRLPGEAQKIDRLMEKFASRYC--ECNPKNQLFQ---------------------SADTVYV 710
            |..||||||:|:|:|::|.|:|:|.  :.|.|.:|..                     .||:|:|
Yeast   628 LTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIHVQPDADSVFV 692

  Fly   711 LAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGM 775
            |::|||||.||.|:||||..||.:.|....||..:.| |.|..||..||..|...||.|..
Yeast   693 LSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGK-DFPRWYLHKIYTSIKVKEIVMPE---- 752

  Fly   776 LQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVS---HVKSPFTSAKHLEHVRPMFKM 837
                :..|.:.:..:     .||           ||:.|.|   .::..||:        |:.|:
Yeast   753 ----EHHGNERWFED-----AWN-----------NLISSTSVMTEMQRDFTN--------PISKL 789

  Fly   838 AWTPFL----AAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALAR-FTLLNA 897
            |....|    |.|                                |..||..::.|.: ||:.::
Yeast   790 AQIDILQYEKAIF--------------------------------SNVRDIILKTLFKIFTVASS 822

  Fly   898 NSPINEMKAKNIDTIKTLIMVAHTDGNYLGS---SWLDIVKCISQLELAQLIGTGVRPQFLSGAQ 959
                :::..:.:|.|.....:     ||..|   |:.|.|     |.|.::         .:.||
Yeast   823 ----DQISLRILDAISKCTFI-----NYYFSFDQSYNDTV-----LHLGEM---------TTLAQ 864

  Fly   960 TTLK------DSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQ 1018
            ::.|      ||: |.|:..:.:|.|: :.|:...|..|.         :|...||.|
Yeast   865 SSAKAVELDVDSI-PLVEIFVEDTGSK-ISVSNQSIRLGQ---------NFKAQLCTV------- 911

  Fly  1019 QQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFA-LDSLRQLSMKFM 1082
                 ...|.|.|||..::...|| |::|.|::.:.|..:....|  :.||. ..||.:|....:
Yeast   912 -----LYFQIIKEISDPSIVSTRL-WNQIVQLILKLFENLLMEPN--LPFFTNFHSLLKLPELPL 968

  Fly  1083 EKGEFS--NFRFQKDFLRPFEHIMKKNASPAIRDM-----VVRCIAQMVNSQAHNIRSGWKNIFS 1140
            ...:.|  ..:..:..|..|...:|.:..|:..|:     ...|:     ..:|.:.       |
Yeast   969 PDPDISIRKAKMSRSLLSTFASYLKGDEEPSEEDIDFSIKAFECV-----KASHPLS-------S 1021

  Fly  1141 IFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFATARFPDTSMEAIRL 1205
            :|     :|.:.:.....:|   ::..|...:.:.....|:..:..|.|.:.....:.|..
Yeast  1022 VF-----ENNQLVSPKMIET---LLSSLVIEKTSENSPYFEQELLFLLEISIILISEASYG---- 1074

  Fly  1206 VRTCAQCVHEAPQLFAEH-AGMENDASVAEEDRVWVRGWFPMLFSLSCVVNRCKL--DVRTRALT 1267
                    .|...|.|:| ..:.|...:::|....:..:  .:|.:|...|...:  |:......
Yeast  1075 --------QEFGALIADHMINISNLDGLSKEAIARLASY--KMFLVSRFDNPRDILSDLIEHDFL 1129

  Fly  1268 VLFEIVKT-YGESFKPHWWKDLFNVIFRIFDNMKLPEHVTEKSE-W-------MTTTCNHALYAI 1323
            |..||..| |.||   .|.|.:.|.:|...:::|..|...:..: |       .......|:|..
Yeast  1130 VKNEIFNTKYYES---EWGKQVINDLFTHLNDVKYNERALKNVKFWNFLRILISAKDRQFAVYTF 1191

  Fly  1324 IDVFTQYFDVL---GHL-----LLEELFAQ----LHWCVQQSNEQLARSGTNCLENLVISNGFKF 1376
            ::.:.|..|:.   |:.     ||:|:...    ..|  :|:.|.....|....|    ||.::
Yeast  1192 LEKYIQNGDIFVDDGNFMNILSLLDEMSCAGAVGTKW--EQNYENSVEDGCEAPE----SNPYR- 1249

  Fly  1377 NESTWDKTCQCILDIFNAT--LPQDLLSWRPKAHSSNNIPQEHNHFEALHIRCV-----VQLELI 1434
                      .|:|:.:.:  :..||||...:::|:.|..:.....:.|..:|:     :.::.:
Yeast  1250 ----------SIIDLSSRSINITADLLSTVGRSNSALNKNEIIAAIQGLAHQCLNPCDELGMQAL 1304

  Fly  1435 QTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQLLECQREEQGMYGYLRTRQLLTLADCL 1499
            |.::||:...|:..:.:     :.|.|          .|||.        |.|...:|..:.|..
Yeast  1305 QALENILLSRASQLRTE-----KVAVD----------NLLET--------GLLPIFELDEIQDVK 1346

  Fly  1500 MQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETSSLACVLRIFFKMYGDENRRSDWPGIE 1564
            |      ||..:.....|.:    |.|.:...:...||  ...||.:|       |:..|.|.:|
Yeast  1347 M------KRITSILSVLSKI----FLGQLVEGVTSNET--FLRVLNVF-------NKYVDDPTVE 1392

  Fly  1565 QELVQV 1570
            ::|.::
Yeast  1393 RQLQEL 1398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	355/1696 (21%)
		DCB	30..212	CDD:292830	44/212 (21%)
		Sec7_N	312..465	CDD:289549	33/177 (19%)
		Sec7	582..767	CDD:279680	77/209 (37%)
		DUF1981	1080..1161	CDD:286414	11/87 (13%)
GEA1	NP_012565.1	COG5307	283..1325	CDD:227623	269/1281 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740