Protein Alignment Sec71 and SEC7

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: NP_010454.3
• Gene: SEC7 / 851748
• SGDID: S000002577
• Length: 2009
• Species: Saccharomyces cerevisiae
• Alignment Length: 1913
• Identity: 534/1913 - (27%)
• Similarity: 921/1913 - (48%)
• Gaps: 391/1913 - (20%)

  Fly     3 NNSTKTKEMFIVR-ALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAAL 66
            |.|.....:.:|: .||.||.||||:::.::|  |:.:..|::.|             |..
Yeast   216 NGSNTNSTIILVKTTLETILNDKDIKKNSNAQ--KAIERTLQKFK-------------EFD---- 261

  Fly    67 PLPKNDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSI------------- 118
            |...|: ...:::...|.....:|:::|.::...|||||.||.::..|..::
Yeast   262 PQTTNN-PHYVDSILVFEALRASCRTKSSKVQSLALDCLSKLFSFRSLDETLLVNPPDSLASNDQ 325

  Fly   119 -QDSAN-----PGHLLIDRIVVTIYGCFSGPQTDEAVQLQIIKALLTVVTSQHVE--IHEFTLLQ 175
             ||:|:     |...:||..:.||..||.|..||:.|:|||::||.:.:..:...  .|..:||:
Yeast   326 RQDAADGITPPPKQKIIDAAIDTISDCFQGEGTDDRVELQIVRALSSCILEEDSSSLCHGASLLK 390

  Fly   176 AVRTCYDIYLSSKNLVNQTTARATLTQMLNVIFARMENQVYELPPPNSNPTNGSIHSEDCNGSGE 240
            |:||.|::::.|.|..||..|:|||||:::.::.:::.:                  :..:.:..
Yeast   391 AIRTIYNVFVFSLNPSNQGIAQATLTQIISSVYDKIDLK------------------QSTSSAVS 437

  Fly   241 ESLRDSDEVIASELLAEIISAAYNEAMKDQESVGEPEP-TLNGNDYSSHSDH--------DSVEL 296
            .|.::..:..|.||         :||.::.|:   |.| ||...|..:..:.        ||:.:
Yeast   438 LSTKNHQQQSAIEL---------SEASENAET---PAPLTLENMDKLNDDEERLMDAQQPDSIAI 490

  Fly   297 HSENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAG 361
            .:::.||          ||||||||.:.|:..||| :...|.:||.:|||:||||::..|:::..
Yeast   491 TNQDLAV----------KDAFLVFRVMAKICAKPL-ETELDMRSHAVRSKLLSLHIIYSIIKDHI 544

  Fly   362 PVFRSNEM---------FIMAIKQYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIE 417
            .||.|:.:         ||.:|:|||.:.||.|..|.:..|||::|.|...|::|.:....::|.
Yeast   545 DVFLSHNIFLPGKERVCFIDSIRQYLRLVLSRNAASPLAPVFEVTLEIMWLLIANLRADFVKEIP 609

  Fly   418 VFFKEIFLNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKI 482
            ||..||:..|.|..:|:.:.|...:..:.|||.|.:::|:.|:||||:....|:.|..|:.|:::
Yeast   610 VFLTEIYFPISELTTSTSQQKRYFLSVIQRICNDPRTLVEFYLNYDCNPGMPNVMEITVDYLTRL 674

  Fly   483 AQGRQAL------------------------------ELGANP---------MQEKSMRIRGLEC 508
            |..|..:                              .|.::|         ..:.::::..|.|
Yeast   675 ALTRVEITQTQRSYYDEQISKSLSTYNFSQLPLLTSSNLSSSPDVGQVNLLFPLDFALKMVSLNC 739

  Fly   509 LVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTTIQ----------------TMHSG 557
            :||:|:.:..|:... :|||.......:.:.||:.:.::.:::.                |....
Yeast   740 IVSVLRSLSSWAHKA-LNPNTHTANKVLLNTTSSARQESRSSLSNDVRSSIMTSNDDFKPTYEDE 803

  Fly   558 SSHSLNSNQEQLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCG-DIARWL 621
            .|.||:|......| |...|..|:||..:...|.:||.||:|.:..|.:|..|..... .||:||
Yeast   804 ESRSLSSQNIDADD-PTQFENLKLRKTALSECIAIFNNKPKKAIPVLIKKGFLKDDSPISIAKWL 867

  Fly   622 HEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLME 686
            .|.|.||...:|:|:||.||.:..:|.|::|.|||..|.:|.|||..|:.||||||.|||||.|.
Yeast   868 LETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKIDRFML 932

  Fly   687 KFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLP 751
            |||.|:.:.||  .:|..|||.|||::|:|||.|||||.|:|:||:.:::::.|.|| |:..|||
Yeast   933 KFAERFVDQNP--GVFSKADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEGI-DNGRDLP 994

  Fly   752 EEYLSSIYDEISEHEIK---------MKNNSGMLQQAKPTGKQAFITEKRRKL---LWNMEMEVI 804
            .::|..:::||:.:|||         :..::.::||.    :.||.....|.|   .:|...:.|
Yeast   995 RDFLEGLFNEIANNEIKLISEQHQAMLSGDTNLVQQQ----QSAFNFFNSRDLTREAYNQVSKEI 1055

  Fly   805 SLTATNLMQSVSHVK---SPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGI 866
            |.....:.::::..|   ..:.:|.|:|||:.:|:..|..||||.:...:|.||.:....||:|:
Yeast  1056 SSKTELVFKNLNKNKGGPDVYYAASHVEHVKSIFETLWMSFLAALTPPFKDYDDIDTTNKCLEGL 1120

  Fly   867 RCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNIDTIKTLIMVAHTDGNYLGSSWL 931
            :.:|:||..|.::..|.::|.||.:|..|   ..:.|:|.||::.:..|:.||.::||||..||.
Yeast  1121 KISIKIASTFRINDARTSFVGALVQFCNL---QNLEEIKVKNVNAMVILLEVALSEGNYLEGSWK 1182

  Fly   932 DIVKCISQLELAQLIGTGV----------------RPQFLS------------GAQTTLKD---- 964
            ||:..:||:|..|||..|:                |..:.|            |.:.|..:
Yeast  1183 DILLVVSQMERLQLISKGIDRDTVPDVAQARVANPRVSYESSRSNNTSFFDVWGKKATPTELAQE 1247

  Fly   965 -----SLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQQQ---- 1020
                 :|:|.:.:.|   ||..:||.:|.|||.|..|.|:|||||:|||..||::|::..:
Yeast  1248 KHHNQTLSPEISKFI---SSSELVVLMDNIFTKSSELSGNAIVDFIKALTAVSLEEIESSENAST 1309

  Fly  1021 PRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMKFMEKG 1085
            ||||||||:|::.||||:||:|:|:.:|.|:|:.||.:..|||..:.|||:||||||||:|::..
Yeast  1310 PRMFSLQKMVDVCYYNMDRIKLEWTPLWAVMGKAFNKIATNSNLAVVFFAIDSLRQLSMRFLDIE 1374

  Fly  1086 EFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSGWKNIF-SIFHLAAGDN 1149
            |.|.|.||.|||:|||:.::.:.:..:::|::.|....:.:::.:|:||||.|. |:.:.|....
Yeast  1375 ELSGFEFQHDFLKPFEYTVQNSGNTEVQEMIIECFRNFILTKSESIKSGWKPILESLQYTARSST 1439

  Fly  1150 EEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFA-TARFPDTSMEAIRLVRTCAQ-- 1211
            |..:::.....:..|:.:.::..|: ..|:|.:.|....|.. ..||...|:.|:..:|...|
Yeast  1440 ESIVLKTQLLVSNDIVTNHFENVFS-QEDAFSELVGVFREITKNKRFQKLSLHALESLRKMTQNV 1503

  Fly  1212 ---CVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPMLFSLSCVVNRCK-LDVRTRALTVLFEI 1272
               |.:...:  .|.....|||.:..:| ::...||||||..:..:...: |:||:|||..:|:.
Yeast  1504 ADICFYNENK--TEEERKHNDALLRGKD-IFQDVWFPMLFCFNDTIMTAEDLEVRSRALNYMFDA 1565

  Fly  1273 VKTYGESFKPHWWK--------DLFNVIFRIFDNMKLPEHVTEKSEWMTTTCNHALYAIIDVFTQ 1329
            :..||..|...:|:        .:|.|:.:.::..:...| .:.|.|::||...||..:|.:||.
Yeast  1566 LVAYGGKFNDDFWEKICKKLLFPIFGVLSKHWEVNQFNSH-DDLSVWLSTTLIQALRNLIALFTH 1629

  Fly  1330 YFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDIFNA 1394
            ||:.|.. :|:.....|..|:.|.|:.:||.|.:||:.|::.|..||||..|::.......:|:.
Yeast  1630 YFESLNR-MLDGFLGLLVSCICQENDTIARIGRSCLQQLILQNVSKFNEYHWNQIGDVFDKLFDL 1693

  Fly  1395 TLPQDLLSWRP-----------------------------------------KAH---------- 1408
            |...:|..:.|                                         :||
Yeast  1694 TTANELFDYDPLQQGRKSSVSHHQTTNDTSQHSDDDSNDRRENDSNISETVERAHQEESSEDVGG 1758

  Fly  1409 -----------------------------SSNNIPQEHNHFE----------------ALHIRCV 1428
                                         :|.:||::..|.:                ::.::||
Yeast  1759 DMVETLNGQTKLNNGNSVPTVKDELNPKPASLSIPKKTKHMKRNESNEDIRRRINIKNSIVVKCV 1823

  Fly  1429 VQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQLLECQREEQGMYGYLRTRQLL 1493
            :||.:|:.::.:.                                     |.:.....:..::.:
Yeast  1824 LQLLMIELLNELF-------------------------------------ENEDFAHCIPYKEAI 1851

  Fly  1494 TLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETSSLACVLRIFFKMY-GDENRR 1557
            .:...|.:|:.|::.||.|:..|:.|..|.....: |||||||||:.|.:|.|.|::| .|:.::
Yeast  1852 RITRLLEKSYEFSRDFNEDYGLRTRLVEARVVDKI-PNLLKQETSAAAVLLDIMFQLYLNDDEKK 1915

  Fly  1558 SDWPGIEQELVQVCKEALGYYLSLQS---EAHRDAWTSLLLLILTRLLKMSDARFATHVSNYYSL 1619
            :|   :...|:.:|.:.:..|:||..   |...:||.|:::.||....:..|..|..:....|:|
Yeast  1916 AD---LITRLITICIQVVEGYVSLDDRTMERSINAWRSVIVEILQGYYEFDDEDFRLYCPAMYAL 1977

  Fly  1620 LCEMMCFDLKPELRSVLRRVFMRIGPVF 1647
            :.:::...:..|||..:::...|:|.::
Yeast  1978 VIQILDKSVPTELRHAIKQFLSRVGELY 2005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	515/1831 (28%)
		DCB	30..212	CDD:292830	54/202 (27%)
		Sec7_N	312..465	CDD:289549	61/161 (38%)
		Sec7	582..767	CDD:279680	85/185 (46%)
		DUF1981	1080..1161	CDD:286414	23/81 (28%)
SEC7	NP_010454.3	DCB	<283..426	CDD:406594	46/142 (32%)
		COG5307	504..1693	CDD:227623	387/1210 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I595
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4687
Inparanoid	1	1.050	750	1.000	Inparanoid score	I73
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54931
OrthoFinder	1	1.000	-	-		FOG0001583
OrthoInspector	1	1.000	-	-		oto99601
orthoMCL	1	0.900	-	-		OOG6_100729
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1314
SonicParanoid	1	1.000	-	-		X714
TreeFam	1	0.960	-	-
	14	13.860