DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec71 and Psd2

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_036017188.1	Gene:	Psd2 / 74002	MGIID:	1921252	Length:	771	Species:	Mus musculus

Alignment Length:	401	Identity:	100/401 - (24%)
Similarity:	167/401 - (41%)	Gaps:	93/401 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 EQDQADTTIQTMHSGSSHSLNSNQEQLQDLPEALEERKMRKEVMETGIELFNRKP-QKGVQFLQE 606
            ::|..||. :.::|.|..||   ::.|.|....|...:        |:|..:..| ..|.|.:.|
Mouse   257 DEDDEDTD-KLLNSASDTSL---KDGLSDSDSELSSSE--------GLEPGSTDPLANGCQGVSE 309

  Fly   607 KQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEG 671
                  ....:||.|:..|...:..:...:|:|::.|:.|...|:..|||..:.:..|||..|:.
Mouse   310 ------AARRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDRALRTFLKA 368

  Fly   672 FRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHS-PQVKHKMTKEQ 735
            |.|.||.|:.:|::..|:.|||:|||.:.  .|.|.::.|..::::|.||||. ..:..||:.:|
Mouse   369 FPLMGETQERERVLTHFSRRYCQCNPDDS--TSEDGIHTLTCALMLLNTDLHGHVNIGKKMSCQQ 431

  Fly   736 YI----KMNRGISDSKSDLPEEYLSSIYDE-----ISEHEIKMKNNSGMLQQAKPTGKQAFITEK 791
            :|    ::|.| .|...||.:...:||.:|     |.|.|:: |:.|.::.....||     |:|
Mouse   432 FIANLDQLNDG-QDFAKDLLKTLYNSIKNEKLEWAIDEDELR-KSLSELVDDKFGTG-----TKK 489

  Fly   792 RRKLL--WNMEMEV-ISLTATNLMQSVSHVKSPFTSAKHLE---HVRPMFKMAWTPFLAAFSVGL 850
            ..::|  .|..::| .:|.||.....|      .|...|.:   ...|..:..|..|.|...
Mouse   490 VTRILDGGNPFLDVPQALNATTYKHGV------LTRKTHADMDGKRTPRGRRGWKKFYAVLK--- 545

  Fly   851 QDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAY--VQALARFTLLNA--------------NS 899
                    .|:                :.|::|.|  .:||:...|.||              :.
Mouse   546 --------GTI----------------LYLQKDEYRLDKALSEGDLKNAIRVHHALATRASDYSK 586

  Fly   900 PINEMKAKNID 910
            ..|.:|.|..|
Mouse   587 KSNVLKLKTAD 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	100/401 (25%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	57/195 (29%)
		DUF1981	1080..1161	CDD:286414
Psd2	XP_036017188.1	Sec7	294..462	CDD:238100	53/176 (30%)
Psd2	XP_036017188.1	PH_EFA6	508..631	CDD:270107	22/123 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838952
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740