DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec71 and Cyth4

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_082471.2	Gene:	Cyth4 / 72318	MGIID:	2441702	Length:	393	Species:	Mus musculus

Alignment Length:	252	Identity:	101/252 - (40%)
Similarity:	150/252 - (59%)	Gaps:	25/252 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 DQADTTIQTMHSGSSHSLNS----NQEQLQDLP----------------EALEERKM--RKEVME 587
            |...|....:.||.:..|..    .::.|:|:.                |:.||.:|  :::.|.
Mouse     2 DVCHTDPAELSSGEAKELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFESTEESRMAQKEKEMC 66

  Fly   588 TGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYID 652
            .|.:.||..|.||:|:|.|.:||.:...|||::|::.:.|:||.||.|:||.|..:.:|:.|::|
Mouse    67 IGRKKFNMDPNKGIQYLIEHKLLTSDVQDIAQFLYKGDGLNKTAIGTYLGEKDPINLQVLQAFVD 131

  Fly   653 AFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIM 717
            ..:|..:.:|.|||..|..||||||||||||:||.||:|||.|||  .:|:|.||.|||:||:||
Mouse   132 CHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAARYCLCNP--GVFRSTDTCYVLSFSVIM 194

  Fly   718 LTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSG 774
            |.|.||:|.|:.:...|:::.||||| :|.||||||.|.:::|.|......:..:.|
Mouse   195 LNTGLHNPNVRDRPPFERFVTMNRGI-NSGSDLPEEQLRNLFDSIKSEPFSIPEDDG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	101/252 (40%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	89/184 (48%)
		DUF1981	1080..1161	CDD:286414
Cyth4	NP_082471.2	Sec7	61..243	CDD:279680	89/184 (48%)
		PH_GRP1-like	258..376	CDD:269954
		PH	262..374	CDD:278594
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..275
		C-terminal autoinhibitory region. /evidence=ECO:0000250	386..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810