Protein Alignment Sec71 and Iqsec1

DIOPT Version :10

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: XP_038964676.1
• Gene: Iqsec1 / 686590
• RGDID: 1596313
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 934
• Identity: 206/934 - (22%)
• Similarity: 341/934 - (36%)
• Gaps: 301/934 - (32%)

  Fly    13 IVRALEKILADKDIRRSHHSQLKK-----SCDSA--LEQIKAELISAGQIAEGNELPCAALP--L 68
            ||.|.:::||.   ||....:|::     |.::|  ||:.:..|.:..:..:....|..|:|  .
  Rat    21 IVAAQQELLAQ---RRRRIEELERQVARLSRENAGLLERHRRHLAACARRPDPGPSPLGAIPELS 82

  Fly    69 PKNDAASIINAETYFLPFELACKSRSPRIVV----------TALDCLQKLIAY--GHLT-GSIQD 120
            .:.|.:...::.:.....|......:.|..|          |:||...   ||  |.|. ||
  Rat    83 SRRDKSEEESSRSIRSSLETGSSLSTDRYSVEGEAPSSETGTSLDSPS---AYHQGPLVPGS--- 141

  Fly   121 SANPGHLLIDRIVVTIYGCFSGPQTDEAVQLQIIKALLTVVTSQ--------------------- 164
            |.:|.|  .:...|..||.::||...:..:...::...:|:..|
  Rat   142 SLSPDH--YEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSD 204

  Fly   165 ----HVEIHEFT---------LLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIFARMENQV- 215
                .||:.|..         ..:.::|.:..|..:||.....::.:.......::.:.|..|.
  Rat   205 LQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFS 269

  Fly   216 YELPP--------------PNSNPTNGSIHSEDCNGSGEESLR----DSDEVIA-SEL------- 254
            :|.|.              .|.....|::...:|....:.:|:    .||...| :||
  Rat   270 FEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQ 334

  Fly   255 ---LAEIISAAYNEAMKDQESV----------GEPEPTLNGNDY-------SSHSDHDSVELHSE 299
               |||.|..|.|......|.|          .||:|.|:|.|:       :|:||   |.|:.:
  Rat   335 VKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSD---VTLYID 396

  Fly   300 NDAVVTAKFTHILQKDAFLVFRALCKLSMKPLP----DGHPDPKSHELRSKVLSLHLLLLILQNA 360
            .:                       :|| .|||    ...|.....:||            |::.
  Rat   397 EE-----------------------ELS-PPLPLSQAGDRPSSTESDLR------------LRSG 425

  Fly   361 GPVFRSNEMFIMAIKQYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFL 425
            |   .:.:.:.:|.|:  ..|.::......|.:......:.|.       ||.          .|
  Rat   426 G---AAQDYWALAHKE--DKADTDTSCRSTPSLERPEPRLRVE-------HLP----------LL 468

  Fly   426 NILEANSSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKI-AQGRQAL 489
            .|...:.||.|                                  |.:|  :|.|.: .|.....
  Rat   469 TIEPPSDSSVE----------------------------------LSDR--SDRSSLKRQSAYER 497

  Fly   490 ELGAN----------------PMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQS 538
            .||..                |.:|..:|                           |.||..::|
  Rat   498 SLGGQQGSPKHGPHGGPPKGLPREEPELR---------------------------PRPPRPLES 535

  Fly   539 ----------PTSTEQDQADTTIQTMHSGS-----------SHSLNSNQEQL------------- 569
                      .:.:|.|.:|....:::|.|           |.|.:|.:||.
  Rat   536 HLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNS 600

  Fly   570 QDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGN 634
            .|.| |.....:||.....|:.|||:||:||:|:|.|:..:..|...:|.:|.:.:.|.:.:||.
  Rat   601 WDSP-AFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGE 664

  Fly   635 YIGEND-DHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNP- 697
            ::|... ..:::|:...:|..||..||:..|||......|:.|||||::||:|.|:.|||.|||
  Rat   665 FLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPG 729

  Fly   698 KNQLFQSADTVYVLAFSIIMLTTDLHSPQVK--HKMTKEQYIKMNRGISDSKSDLPEEYLSSIYD 760
            ..:.|::.||:::|||:||:|.||::||.||  .||..|.::|..||:.|.: |:|.|.|..||:
  Rat   730 VVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGE-DIPRETLIGIYE 793

  Fly   761 EISEHEIKMKNNSGMLQQAKPTGK 784
            .|.:.|  :|.|...:.|.:...|
  Rat   794 RIRKRE--LKTNEDHVSQVQKVEK 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	206/934 (22%)
Iqsec1	XP_038964676.1	Sec7	612..800	CDD:460178	75/190 (39%)
		IQ_SEC7_PH	832..961	CDD:465120