DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and Mon2

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_011241835.1	Gene:	Mon2 / 67074	MGIID:	1914324	Length:	1716	Species:	Mus musculus

Alignment Length:	1495	Identity:	279/1495 - (18%)
Similarity:	497/1495 - (33%)	Gaps:	534/1495 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ALEKILAD--KDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPKNDAASIIN 78
            |::|:|.:  .|: |:...:.||......|..::.:|....||..|....|||   |.:::.::.
Mouse     9 AVKKLLENMQSDL-RALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAAL---KENSSEVVQ 69

  Fly    79 AETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGCFSGP 143
                  ||.:.|.::.|:|....|..:|:|::  |...|...:.|..::|...:
Mouse    70 ------PFLMGCGTKEPKITQLCLAAIQRLMS--HEVVSETAAGNIINMLWQLM----------- 115

  Fly   144 QTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIF 208
             .:...:|::::.:|.::|:..| :|:..|.:|:..|:.::.:..|:.|.|.| ||:.|::.|:|
Mouse   116 -ENSLEELKLLQTVLVLLTTNTV-VHDEALSKAIVLCFRLHFTKDNITNNTAA-ATVRQVVTVVF 177

  Fly   209 ARMENQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDSDEVIASELLAEIISAAYNEAMKDQESV 273
            .||.                   :||                                  |:...
Mouse   178 ERMV-------------------AED----------------------------------DRHRD 189

  Fly   274 GEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLP---DGH 335
            .||...:.||              |...:|.|.:   ...|||:::|:.||:|.....|   .|.
Mouse   190 IEPPVPIQGN--------------SNRRSVSTLR---PCAKDAYMLFQDLCQLVNADAPYWLVGM 237

  Fly   336 PDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVAL-------------SNNGV 387
            .:      .::...|.||..:|.:...||..::.|...:|:.:|..:             |:...
Mouse   238 TE------MTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSS 296

  Fly   388 SLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFK------EIFLNILEANSSSFEHKWM---VIQ 443
            |..| |.:....|.:.||....|.:|:    |:.      ||||::|.....|.:.:|:   .::
Mouse   297 SPAP-VEKPYFPICMRLLRVVSVLIKQ----FYSLLVTECEIFLSLLVKFLDSDKPQWLRAVAVE 356

  Fly   444 ALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLEC 508
            ::.|:|...|.:.....:||....:..:|..:||.|....|
Mouse   357 SIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQ------------------------ 397

  Fly   509 LVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQLQDLP 573
                         .|::     |||  ..:|.:..|      ....::|...|..:|
Mouse   398 -------------SLFL-----VPP--TGNPATANQ------AGNNNAGGPASAPAN-------- 428

  Fly   574 EALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGE 638
                     ..|:..|         .||..|...:..||       |:   ..|..||.|:
Mouse   429 ---------SGVVGVG---------GGVTLLPAFEYRGA-------WI---PILTVTVQGS---- 461

  Fly   639 NDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQ 703
                   ....|::..|..:...:.      ||:.:.
Mouse   462 -------AKATYLEMLDKVEPPTIP------EGYAMS---------------------------- 485

  Fly   704 SADTVYVLAFSIIM-----LTT---------DLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEY 754
                   :||..::     :||         :...|.|            ..|.|...|:..:|.
Mouse   486 -------VAFHCLLDLVRGITTMIEGELGEVEAEGPSV------------TEGASSQSSERRDEQ 531

  Fly   755 LSSIYDEISEHEIKMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVK 819
            .:|                      .|..::..::    :.:|.   |::|
Mouse   532 AAS----------------------DPMDQETAVS----RAVWE---EMVS-------------- 553

  Fly   820 SPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACI---FHMSLE 881
                             ..|...|||.|: |.|....|.||..:  ::..:.:|.:   ..:...
Mouse   554 -----------------ACWCGLLAALSL-LLDASTDEAATENI--LKAELTMAALCGRLGLVTS 598

  Fly   882 RDAYVQALAR--------FTLLNAN--------------------SPINE--------------- 903
            |||::.|:.:        .|:|||.                    ||.:|
Mouse   599 RDAFITAICKGSLPPHYALTVLNATTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQ 663

  Fly   904 ------MKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQL------------IGTGV 950
                  :.:|||..::||:.:||..|..||:||        ||.||.|            .|..:
Mouse   664 PQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSW--------QLVLATLQHLVWILGLKPSSGGAL 720

  Fly   951 RP-QFLSGAQTTLKDSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVD 1014
            :| :.:.|..|.|..::         .|....:...:.|:|..|..||..::...:.|||.:|::
Mouse   721 KPGRAVEGPSTVLTTAV---------MTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLE 776

  Fly  1015 EL-----QQQQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGC---NSN-EEISFFA 1070
            .:     ..::|.:|::.|::|....||.||.:    :|:.|..|.....|   ||. .|....|
Mouse   777 AMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEI----LWRPLTGHLLEKVCQHPNSRMREWGAEA 837

  Fly  1071 LDSLRQLSMKFMEKGEF-SNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSG 1134
            |.||.:..:.|..:... .|.|.|...|.|.:.:...| .|.||...:.|:.|::.||..::..|
Mouse   838 LTSLIRAGLTFSHEPPLPQNQRLQLLLLNPLKEMSNIN-HPDIRLKQLECVLQILQSQGDSLGPG 901

  Fly  1135 WKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQ----FAIMVD---SF----QDAVKCLS 1188
            |..:..:......|..|.::..|||....::.|.....    ..|:||   ||    |:.
Mouse   902 WPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCSCLQIVVDVAGSFGLHNQEL----- 961

  Fly  1189 EFATARFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDA--SVAEEDRVWVRG--------- 1242
                    :.|:.:|.|:...:....:..:...:....|..|  ..|||..|.:..
Mouse   962 --------NISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVSLNRPFHPAPPFD 1018

  Fly  1243 --WFPMLFSLS--CVVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKD-LFNVIFRIFDNMK-- 1300
              |..:...|.  ||..|..  ||..|...||..:..:|...:...|.. ::.|:|.:.|.::
Mouse  1019 CLWLCLYAKLGELCVDPRPA--VRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRES 1081

  Fly  1301 ----------------LPEHVTEKSE------WMTT---------TCNHALYAIIDVFTQYFDVL 1334
                            |..|..:.:|      |:.|         |..:.|..:.| |::.:|||
Mouse  1082 STTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGD-FSRAWDVL 1145

Fly 1335 1334
Mouse 1146 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	279/1495 (19%)
		DCB	30..212	CDD:292830	41/181 (23%)
		Sec7_N	312..465	CDD:289549	40/177 (23%)
		Sec7	582..767	CDD:279680	27/198 (14%)
		DUF1981	1080..1161	CDD:286414	21/81 (26%)
Mon2	XP_011241835.1	DCB	9..180	CDD:374438	45/196 (23%)
		Sec7_N	211..378	CDD:372313	40/177 (23%)
		DUF1981	<871..930	CDD:370432	15/59 (25%)
		Mon2_C	933..1707	CDD:374431	43/229 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810