DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec71 and cyth4a

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_695228.4	Gene:	cyth4a / 566849	ZFINID:	ZDB-GENE-090624-6	Length:	411	Species:	Danio rerio

Alignment Length:	365	Identity:	116/365 - (31%)
Similarity:	180/365 - (49%)	Gaps:	65/365 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 VQSPTSTEQDQADTTIQTMHSGS------SHSLNSNQEQ---------LQDLP------------ 573
            ::||.||      .|:.|....|      ..|.|:|.::         |.|:.
Zfish     1 MKSPCST------ATMGTQRKDSFLWGKAPSSFNANDKKQTEVHKHVILDDIKQLRMEIENMMTE 59

  Fly   574 ----EALEERK--MRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVI 632
                ||.:|.|  |:.:.::.|.:.||..|:||:|:|.:..||......:|.:|:::|.|:||.|
Zfish    60 IQTMEADDENKNVMKNKRIQCGKKKFNMDPKKGIQYLVDNGLLAWKPESVAEFLYKEEGLNKTAI 124

  Fly   633 GNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNP 697
            ||::||.::...:::.|::...:|..:.:|.|||..|..||||||||||||:||.||.|||.||
Zfish   125 GNFLGEREEIHLQILQAFVHLHEFSNLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCTCN- 188

  Fly   698 KNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEI 762
             ..:|||.||.|:|:|:||||.|.||:|.||.|.|.|::|.|||||::. .|||.|.|..:|:.|
Zfish   189 -TGVFQSTDTCYILSFAIIMLNTSLHNPNVKDKTTLERFISMNRGINNG-GDLPSELLEKLYESI 251

  Fly   763 SEHEIKMKNNSGM-LQQA--KPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTS 824
            .....|:..:.|. |...  .|..:...:.|..|...|.....:::.......|        :|:
Zfish   252 KNEPFKIPEDDGNDLTHTFFNPDREGWLLKEGGRIKTWKRRWFILTDGCLYYFQ--------YTT 308

  Fly   825 AKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLD 864
            .|..:.:.|:..:.           :::.|||. ...||:
Zfish   309 DKEPKGIIPLENLC-----------VKEVDDPH-KQFCLE 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	116/365 (32%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	83/184 (45%)
		DUF1981	1080..1161	CDD:286414
cyth4a	XP_695228.4	Sec7	74..256	CDD:279680	83/184 (45%)
		PH_GRP1-like	271..390	CDD:269954	13/86 (15%)
		PH	275..387	CDD:278594	12/82 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740