DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and gbf1

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_009305378.1	Gene:	gbf1 / 566350	ZFINID:	ZDB-GENE-081107-54	Length:	1862	Species:	Danio rerio

Alignment Length:	1981	Identity:	413/1981 - (20%)
Similarity:	737/1981 - (37%)	Gaps:	590/1981 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KEMFIVRA-LEKILA--DKDIRRSHHSQLKKSCDSALEQ---IKAELISAGQIAEGNELPCAALP 67
            |.::||:. :..::|  .::.|.|.|:.|.:..|:.|..   :|..|.:...:::
Zfish     4 KNIYIVQGEISVVVAAIKRNSRWSTHTPLDEEQDTLLNSFRLLKERLNNIKDLSD---------- 58

  Fly    68 LPKNDAASIINAETYFLPFELACKSRSPRIVVT--ALDCLQKLIAYGHLTGSIQDSANPGHLLID 130
                     :....:..||....:|......:|  ||..:.|.::||.:..:.:.:|.....:.|
Zfish    59 ---------VEPNVFLRPFLEVVRSEDTTGPITGLALTSVNKFLSYGLIDANHEGAAECIENMAD 114

  Fly   131 RIVVTIYGCFSG--PQTDEAVQLQIIKALLTV--------VTSQHV-EIHEFTLLQAVRTCYDIY 184
            .:.   :..|.|  |.:||.|.::|::.|.|:        :|::.| ||    :....|.|:::.
Zfish   115 AVT---HARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEI----MQSCFRICFEMR 172

  Fly   185 LSSKNLVNQTTARATLTQMLNVIFARM-----------------------ENQVYEL-------- 218
            ||.   :.:.:|..||..|:.::|:|:                       :|:..:|
Zfish   173 LSE---LLRKSAEHTLVDMVQLLFSRLPQFKEEAKSYVGTNMKKAYNILWKNKRVQLKMRAGGMS 234

  Fly   219 ---------------------PPPNSNPTNGSIHSEDCNG--------SGEESLRDSDEVIASEL 254
                                 |....:|...|..:.:.:|        ||..|.....:..||.:
Zfish   235 ESSKWKKQKRSPRPPRHMVRSPSGQMDPAQSSTLTNNLSGGVPFIEQHSGGSSTFPGSDSAASSI 299

  Fly   255 LAEIISAAYNEAMK----------DQES--VGEP-EPTLNGNDYSSHSDHDSVE----------- 295
            .:....:..:...|          ||.|  ...| .|:.......|.|:...||
Zfish   300 SSPTTDSGLDTGSKTTSKEDLTDLDQNSSTATTPITPSAEPGRLESQSEGRGVERAQSASVESIP 364

  Fly   296 --------LHSENDAVVT----------AKFTHILQKD-AFLV----------FRALCKLSMKPL 331
                    |..::|:...          .:||...||: |.|:          ||.|..|: .|.
Zfish   365 EVLEDRDLLADQSDSASVHDMDYVNPRGVRFTQSTQKEGAALIPYGLPCLRELFRFLISLT-NPH 428

  Fly   332 PDGHPDPKSHELRSKVLSLHLLLLILQNA--GPVFRSNEMFIMAIKQYLCVALSN-NGVSLVPEV 393
            ...:.|...|      :.|.||.:.|:.|  .|.    :..:..:|..||..|.. .||..: .:
Zfish   429 DRHNSDVMMH------MGLQLLNVALEAAHIAPY----QSLLGLVKDELCRHLIQLLGVDRM-NL 482

  Fly   394 FELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEAN-SSSFEHKWMVIQALTRICADAQSVVD 457
            :..|:.:...|..:.:.|||.|:|::.|::...|...| ...:|.|.|.::|:.::......|.:
Zfish   483 YTASIRVCFLLFESMREHLKFQLEMYLKKLMDIITSENPKMPYEMKEMALEAIVQLWRIPSFVTE 547

  Fly   458 IYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPM--QEKSMRIRGLECLVSILKCMVEWS 520
            :|:||||||..:||||.|...|||          .|.|:  |..:..:..||.|::::.......
Zfish   548 LYINYDCDFYCSNLFEDLTKLLSK----------NAFPVSGQLYTTHLLSLEALLTVIDSTEAHC 602

  Fly   521 KDLYVNPNMPVPPMQVQSPTSTEQDQADTTI--QTMHSGSSHSLNSNQEQL-------------- 569
            :...:|.    ...|.||.::|..|.:.:||  ....:|..|..::.|..:
Zfish   603 QAKVLNS----ATQQEQSESTTVGDSSVSTITDSPAETGKPHPSSNGQNSVVSETRASCPPTSGH 663

  Fly   570 ----------QD---------------------LPEALE--ERKMRKEVMETGIELFNRKPQKGV 601
                      ||                     ||::.|  |.|.:|:::.||.|.||:||:||:
Zfish   664 LMAEKMRLGRQDQEETDTGEKKISKKPHRFSSYLPDSQELLEIKNKKKLLITGTEQFNQKPKKGI 728

  Fly   602 QFLQEKQLLGATC--GDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAA 664
            |.||||.||.:..  .::|:||.|:.||||.:||.:|  :|..:.:::.::::.|.|:.:.:..|
Zfish   729 QTLQEKGLLSSPMDNNEVAQWLRENPRLDKKMIGEFI--SDRRNTDLLDSFVNTFTFQGLRIDEA 791

  Fly   665 LRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKH 729
            ||..||.|||||||..|.||:|.|...:.:.|  ...||:.|..:.||:::|||.||.|:..|:.
Zfish   792 LRLYLEAFRLPGEAPVIHRLLETFTDNWHKVN--GNPFQTNDAGFALAYAVIMLNTDQHNHNVRK 854

  Fly   730 K---MTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKN-NSGMLQQAKPTGKQAFITE 790
            :   ||.||:.|..:|::.. :|..::.|..||:.|...||.|.: .:|::::
Zfish   855 QNIPMTLEQFKKNLKGVNGG-NDFDQDMLEDIYNAIKNEEIVMPDEQTGLVKE------------ 906

  Fly   791 KRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDD 855
               ..:|::           |:...:..:..|.......:.|.:|.|.|.|.:||.|.......|
Zfish   907 ---NYVWSV-----------LLHRGASAEGMFLHVPDGSYDRDLFSMTWGPTIAALSYVFDKSLD 957

  Fly   856 PEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNIDTI-------- 912
            ..|....:.|.|....|:..:..|...|..:.:|.:||.|::.|      .:|:.|:
Zfish   958 DTIIEKAIAGFRKCAMISAHYGFSDVFDNLIISLCKFTTLSSES------VENLPTVFGSNRKAQ 1016

  Fly   913 ---KTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQTTLKDSLNPSVK--- 971
               ||:..:||..|:.|...|.:|:..:.||         .|.:.|......::|.|:|:.|
Zfish  1017 VAAKTVFSLAHRHGDILRDGWKNIMDSMLQL---------FRAELLPKTMVEVEDFLDPNEKISL 1072

  Fly   972 ------------------------EHIG--------ETSSQSVVVAV-----DRIFTGSMRLDGD 999
                                    |..|        :.:.|:.::.:     :::.|.|..|..:
Zfish  1073 QREETPSNRGESAVLSFVSWLTLSEQSGLRGPSTENQEAKQAALLCIKQCDPEKLNTESKFLQLE 1137

  Fly  1000 AIVDFVKALCQVSVD-ELQQQQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSN 1063
            ::.:.:|||..|:.| |...::...|.|:.::.|...|.:|:    |.:||.:.:|...:..::|
Zfish  1138 SLQELMKALISVTPDEETYDEEDAAFCLEMLLRIILENRDRV----SCVWQTVRDHLYQLCVHAN 1198

  Fly  1064 EEISFF----ALDSLRQLSMKFMEKGEF-SNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIA-- 1121
            |  |.|    |:..|.:|:::.:.:.:. |........|     :|.|   |.:...|.|.:|
Zfish  1199 E--SCFLVERAVVGLLRLAIRLLRREDIGSQVLLSLRLL-----LMMK---PHVLSRVSREVAYG 1253

  Fly  1122 --QMVNSQAHNIRS--GWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQD 1182
              :::.:.|.||.|  .|..:||:.. ..|...:|...|.|..|..              |: ..
Zfish  1254 LHELLKTNAANIHSTDDWYTLFSLLE-CIGAGIKPPAALQFANTNP--------------DN-DT 1302

  Fly  1183 AVKCLSEFATARFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPML 1247
            ..:..||.::....:.|::         :......:::.||.......|..:.|..|:
Zfish  1303 GAQSDSELSSYHQSEVSLD---------RGYTSDSEIYNEHGKSRIPRSATDVDVGWL------- 1351

  Fly  1248 FSLSCVVNRCKLDVRTRALT---------VLFEIVKTYGESFKPHWWKDLFNVIFRIFDNMKLPE 1303
                 ||.:..||....|:|         ::.:...|.|:....|..|.|...:..:...::...
Zfish  1352 -----VVGKDDLDGAKAAVTTPSKPMNHPLVNQYSLTLGQDMGLHDTKSLIKCVDSLSFIVRDAA 1411

  Fly  1304 HVTEKSEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLENL 1368
            |||.::                     |::               ||:.....:..|
Zfish  1412 HVTPEN---------------------FEL---------------CVKAIRVFVEAS-------- 1432

  Fly  1369 VISNGFKFNESTWDKTCQCILDIFNATL---PQDL--LSWRPKAHSSNNIPQEHNHFE------- 1421
             ::.|::    |.:|......|..::.|   |::.  .|.|.|| ||....:.|:..|
Zfish  1433 -LNGGYR----THEKKKSHKYDSKSSRLRKKPREKEGASRRTKA-SSQRPARSHSDDEEEEGVPA 1491

  Fly  1422 ALH-IRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQLLECQR--EEQGM 1483
            :.| :...|.|:|:..|               .||...||       |..|...|.||  |:.|.
Zfish  1492 SYHTVSFQVSLDLLDLM---------------HTLHTRAA-------GIYSSWAEEQRHLEDAGK 1534

  Fly  1484 YGYLRTRQLLTLADC-----------------LMQSHRFAKRFNADHDQRSL---LWRAGFKGSV 1528
            .....::.|.|...|                 .||:..:.:|....||.::|   .|.:.|...:
Zfish  1535 KIEADSQTLWTSCWCPLLQGMAWLCCDARRQVRMQALTYLQRALLVHDLQTLDAVEWESCFNKVL 1599

  Fly  1529 KPNLLK-------------QETSSLACVLRIFFKMYGDENRRSDWPGIEQELVQVCKEALGYYLS 1580
            .|.|.|             :||...||.|                      |.:|..:.|...||
Zfish  1600 FPLLTKLLENISPADVGGMEETRMRACTL----------------------LSKVFLQHLSPLLS 1642

  Fly  1581 LQS-------------------------EAHRDAWTSLLLLILTR-LLKMSDARFATHVSNYYSL 1619
            |.:                         ||..::..::||::.|. :...:|:|  |..|:.:.:
Zfish  1643 LPTFAALWLTILDFMDKYMHAGSSDLLLEAIPESLKNMLLVMDTAGIFHSADSR--TGYSDLWEI 1705

  Fly  1620 LCE-MMCFDLKPELRSVLRRVFMRIGPVFNI 1649
            ..| ::||  .|.|:..|.:..:...||.|:
Zfish  1706 TWERIVCF--LPRLKEELFKQAVIPEPVCNV 1734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	391/1879 (21%)
		DCB	30..212	CDD:292830	40/220 (18%)
		Sec7_N	312..465	CDD:289549	42/167 (25%)
		Sec7	582..767	CDD:279680	72/189 (38%)
		DUF1981	1080..1161	CDD:286414	19/87 (22%)
gbf1	XP_009305378.1	Sec7_N	410..555	CDD:289549	38/156 (24%)
		COG5307	493..>1170	CDD:227623	184/736 (25%)
		Sec7	709..894	CDD:279680	72/189 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750