DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and LOC560461

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_009302231.1	Gene:	LOC560461 / 560461	-ID:	-	Length:	1639	Species:	Danio rerio

Alignment Length:	532	Identity:	135/532 - (25%)
Similarity:	237/532 - (44%)	Gaps:	125/532 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 YVNPNMPVPPMQVQSPTST-----------EQDQAD--------TTIQTMH--SGSSHSLNSNQE 567
            |.:|..|.|.....:|.|:           ||...|        .:.:|::  |||| |.:|.:|
Zfish   641 YPDPTSPSPTQPPLTPLSSSSSAPLPASGMEQSDGDNDSLNSTTNSNETINCSSGSS-SRDSLRE 704

  Fly   568 QLQDLPEALEERKMR---------KEVME-----TGIELFNRKPQKGVQFLQEKQLLGATCGDIA 618
            .|..|.:...:|:.|         .:|::     .|:.|||:||:||:|:|.|:..:..|...||
Zfish   705 PLPPLGKQTYQRESRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFVSDTPVGIA 769

  Fly   619 RWLHEDERLDKTVIGNYIGEND-DHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKID 682
            |::.|.:.|.:.:||.::|... ..:|:|:...:|..||..|::..|||......::.|||||::
Zfish   770 RFILERKGLSRQMIGEFLGNRQKQFNKDVLDCVLDEMDFSGMDLDDALRKFQAQIKVQGEAQKVE 834

  Fly   683 RLMEKFASRYCECNPK-NQLFQSADTVYVLAFSIIMLTTDLHSPQVK--HKMTKEQYIKMNRGIS 744
            ||:|.|:.|||.|||. .:.||:.||:::|||:||:|.||::||.||  .||..|.:||..||:
Zfish   835 RLVEAFSQRYCVCNPALVRQFQNPDTIFILAFAIILLNTDMYSPNVKAERKMKLEDFIKNLRGV- 898

  Fly   745 DSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKP---TGKQAFITEKRRKLLWNMEMEVIS- 805
            |:..|:|.:.|..||..|.:.|::..::.....||..   .||:..::...|:|:...::..:.
Zfish   899 DNGQDIPRDLLVGIYQRIQKWELRTNDDHVSQVQAVERVIVGKKPVLSLPHRRLVCCCQLYEVPD 963

  Fly   806 --------------------LTATNLMQ----SVSH-VKSPFTSAKHLEHVRPMFKMAWTPFLAA 845
                                |..|.:.|    ||:: .:..|...:...|   ||:.::
Zfish   964 PNRPQRSGVHQREVFLFNDLLVVTKIFQKKKTSVTYSFRQSFPLVEMQVH---MFQNSY------ 1019

  Fly   846 FSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFT--LLNANSPINEMKAKN 908
            ::.|::       .|..:.|....:.|  :|:...::|.     .|||  |..:.:.:.:|:...
Zfish  1020 YAHGIR-------LTSAMPGAERKVLI--VFNAPSQQDR-----TRFTSDLRESIAEVQDMEKYR 1070

  Fly   909 IDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQTTLKDSLNPSVKEH 973
            ::                           |:||..:.:   :||..|||..:::......:|...
Zfish  1071 VE---------------------------SELEKQKGV---MRPGLLSGEVSSVGGMKTEAVNGT 1105

  Fly   974 IGETSSQSVVVA 985
            :|..|......|
Zfish  1106 LGRPSLDDTYAA 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	135/532 (25%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	76/202 (38%)
		DUF1981	1080..1161	CDD:286414
LOC560461	XP_009302231.1	Sec7	733..918	CDD:279680	74/185 (40%)
		IQ_SEC7_PH	946..1073	CDD:293062	22/176 (13%)
		Sox_C_TAD	1323..>1414	CDD:288887
		SelP_N	<1499..1557	CDD:282453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840