DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sec71 and IQSEC3

DIOPT Version :9

Sequence 1:NP_609675.2 Gene:Sec71 / 34785 FlyBaseID:FBgn0028538 Length:1653 Species:Drosophila melanogaster
Sequence 2:NP_001164209.1 Gene:IQSEC3 / 440073 HGNCID:29193 Length:1182 Species:Homo sapiens


Alignment Length:342 Identity:101/342 - (29%)
Similarity:168/342 - (49%) Gaps:54/342 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   547 ADTTIQTMHSGSSHSLNSNQEQLQ----DLPE------------ALEERKMRKEVMETGIELFNR 595
            :.|:.::..|||..|.:::::.||    .||.            .|....:||.:...|:.|||.
Human   600 SSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNI 664

  Fly   596 KPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGEN-DDHSKEVMCAYIDAFDFRQM 659
            .|.||:|||..:..:..|...:|.:|.:.:.|.:.:||.::|.: ...:::|:...:|..||..|
Human   665 NPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSM 729

  Fly   660 EVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPK-NQLFQSADTVYVLAFSIIMLTTDLH 723
            |:..|||......|:.|||||::||:|.|:.|||.|||: .|.|.:.||:::|||:||:|.||::
Human   730 ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMY 794

  Fly   724 SPQVK--HKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKP----T 782
            ||.:|  .||..|.:|:..||:.|. :|:|.|.:..||:.|.:.|:| .|...:....|.    .
Human   795 SPNIKPDRKMMLEDFIRNLRGVDDG-ADIPRELVVGIYERIQQKELK-SNEDHVTYVTKVEKSIV 857

  Fly   783 GKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMF------------ 835
            |.:..::...|:|:....:  ..:|..|.:|            |...|.|.:|            
Human   858 GMKTVLSVPHRRLVCCSRL--FEVTDVNKLQ------------KQAAHQREVFLFNDLLVILKLC 908

  Fly   836 --KMAWTPFLAAFSVGL 850
              |.:.:.:....||||
Human   909 PKKKSSSTYTFCKSVGL 925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec71NP_609675.2 PLN03076 13..1580 CDD:215560 101/342 (30%)
DCB 30..212 CDD:292830
Sec7_N 312..465 CDD:289549
Sec7 582..767 CDD:279680 72/188 (38%)
DUF1981 1080..1161 CDD:286414
IQSEC3NP_001164209.1 bZIP <32..63 CDD:269834
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 62..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..275
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..479
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..616 5/15 (33%)
Sec7 651..839 CDD:279680 72/188 (38%)
PH_IQSEC 866..996 CDD:270128 14/74 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1090
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1182
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148876
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

Return to query results.
Submit another query.