DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and Efa6

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_001163691.2	Gene:	Efa6 / 42665	FlyBaseID:	FBgn0051158	Length:	1601	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	110/555 - (19%)
Similarity:	212/555 - (38%)	Gaps:	165/555 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 EQDQADTTIQT--MHSGSSHSLNSNQEQLQDLPEALEE---------RKMRKEVMETGIEL---- 592
            ||.:....||.  :.|.||....:|....:|:....:|         |.....|.:.|.::
  Fly  1065 EQSEHKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVESLH 1129

  Fly   593 -FNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDF 656
             ::..| |.|......:|        |:.||..:...|:.:..::.:|:|.|:.|...|:..|.|
  Fly  1130 SYHYSP-KAVDMPSAIRL--------AKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTF 1185

  Fly   657 RQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTD 721
            .:..:..|||..|:.|.|.||.|:.:|::..|:.|:.:|||..  |.|.|.|:.|..:|::|.||
  Fly  1186 EKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLDCNPGT--FNSQDAVHTLTCAIMLLNTD 1248

  Fly   722 LHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKPTGKQA 786
            ||...:..||:..:::.....::|.: :.|::.|.|:|..|
  Fly  1249 LHGQNINRKMSCAEFVDNLADLNDGE-NFPKDVLKSLYQAI------------------------ 1288

  Fly   787 FITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQ 851
                |.:.|.|.::.|     |.:|.|..::     .||        :..:...|||
  Fly  1289 ----KTKPLEWALDEE-----AGDLQQQRAN-----NSA--------LGNVGLNPFL-------- 1323

  Fly   852 DCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNI-DTIKTL 915
              |.||:|| .::..:..:...|.:..|.::                :|..:...|.. .|::.|
  Fly  1324 --DPPELAT-AVEYKKGYVMRKCCYDSSFKK----------------TPFGKRSWKMFYCTLRDL 1369

  Fly   916 IMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQTTLKDSLNPSV---------- 970
            ::..|.|.:                        |.|       ::.:.|:|:.::
  Fly  1370 VLYLHKDEH------------------------GFR-------KSQMSDNLHNAIRIHHALATKA 1403

  Fly   971 -----KEHIG--ETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALC-QVSVDELQQ--------Q 1019
                 |:|:.  :|:.|:     :.:|..|...:..:.|:.:..:| .:|...|:.        |
  Fly  1404 NDYTKKQHVFRLQTADQA-----EYLFQTSDSKELQSWVETINYVCAAISAPPLEGGVGSQKRFQ 1463

  Fly  1020 QPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEH 1054
            :|.:.|.|..:.:. ..::...:|.:::.|.|.||
  Fly  1464 RPLLPSKQSKLMLK-EQLDSHEVQLAQLDQELNEH 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	110/555 (20%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	51/189 (27%)
		DUF1981	1080..1161	CDD:286414
Efa6	NP_001163691.2	PDZ_signaling	7..85	CDD:238492
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	50/208 (24%)
		PH_EFA6	1330..1452	CDD:270107	22/174 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452084
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840