DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec71 and cyth1b

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_005169523.1	Gene:	cyth1b / 325586	ZFINID:	ZDB-GENE-030131-4311	Length:	416	Species:	Danio rerio

Alignment Length:	263	Identity:	107/263 - (40%)
Similarity:	152/263 - (57%)	Gaps:	32/263 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 PVPPMQVQSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQLQDLPEALEE---------------- 578
            |.||......|..|:.:.:           :.....||.|:|:....:|
Zfish    22 PAPPAVPDDLTPEEKQELE-----------NIRRRKQELLEDIQRLKDEITKVTNEIECLGSTQE 75

  Fly   579 --RKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDD 641
              ...|.:.|..|.:.||..|:||:|||.|.:||..||.|||::|::.|.|:||.||:|:||.|:
Zfish    76 RINMQRSKQMAMGRKKFNMDPKKGIQFLIENELLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDE 140

  Fly   642 HSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSAD 706
            .:.:|:.|:::..:|..:.:|.|||..|..||||||||||||:||.||.|||:|||  .:|||.|
Zfish   141 FNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNP--GVFQSTD 203

  Fly   707 TVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKN 771
            |.|||:|:||||.|.||:|.||.|.:.|::|.|||||:|. .||||:.|.::|:.|.....|:..
Zfish   204 TCYVLSFAIIMLNTSLHNPNVKDKPSAERFICMNRGINDG-GDLPEDLLRNLYESIKNEPFKIPE 267

  Fly   772 NSG 774
            :.|
Zfish   268 DDG 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	107/263 (41%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	95/184 (52%)
		DUF1981	1080..1161	CDD:286414
cyth1b	XP_005169523.1	GPS2_interact	18..90	CDD:292412	13/78 (17%)
		Sec7	81..263	CDD:279680	95/184 (52%)
		PH_GRP1-like	278..397	CDD:269954
		PH	282..395	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810