DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and CG5937

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_001096888.2	Gene:	CG5937 / 31537	FlyBaseID:	FBgn0029834	Length:	2051	Species:	Drosophila melanogaster

Alignment Length:	2129	Identity:	371/2129 - (17%)
Similarity:	665/2129 - (31%)	Gaps:	809/2129 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HNNSTKTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAAL 66
            ||...:|.::    |.:|:.....|.|....:|:..|.:||
  Fly    17 HNALRQTAQI----AYDKLYRQHGIHRDPSHELRSVCFTAL------------------------ 53

  Fly    67 PLPKNDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDR 131
                                ::|..::.|:.:...|:.|.::         |:|         :|
  Fly    54 --------------------QMALDTKRPKFITMGLNGLHRV---------IKD---------ER 80

  Fly   132 IVVTIYGCFSGPQTDEAVQL--QIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQT 194
            ..:.:     .|: |::|.|  |:::|                              :..::..|
  Fly    81 FYIGL-----EPE-DDSVWLPSQLLRA------------------------------TNGILPTT 109

  Fly   195 TARATLTQMLNVIFARMENQVYELPPPNSNPTNGSIHSE------DCNGSGEESLRDSDEVIASE 253
            ::..|:..:|.:..|...:....|        ||.:..|      :|...|..:.:.:....||:
  Fly   110 SSEDTVVNVLRLFLAMACSPACTL--------NGRLLIEILSRCGECWEMGSRATKAASLAAASQ 166

  Fly   254 LLAEIISAAYNEAMKDQESVGEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFL 318
            .|....:....||    |.|.:..|.                      .::|......:..:...
  Fly   167 CLRTFCAFLIEEA----EEVKKTAPA----------------------GLMTQTQASAVYNEVIP 205

  Fly   319 VFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGP-VFRSNEMFIMAIKQYLC--- 379
            |.:.||...::|..:..|:.|.....|  |.|...:|.|.:|.| ...:|..|...:.|..|
  Fly   206 VMQWLCSRLVEPNVNASPNKKCENHSS--LYLTECILTLSSALPRNVHANPHFTSFLWQKFCPTL 268

  Fly   380 -VALSNNGVSLVPEVFELSLSIF---------------------------VALLSNFKVH--LKR 414
             .||.:.|...:.:.|....::.                           :.||.....|  |:.
  Fly   269 AAALGSPGRINLDKKFTYKDALHMIENEARGFFTGPGLDGPQARCVYLTAIQLLRIAGAHGSLRP 333

  Fly   415 QIEVFFKEIFLNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFSAAN-------LF 472
            .:|..|..:.|  |.|..:..|    .::.:..|....:.::|:.|....|.:.|.       ||
  Fly   334 MLEALFHRMLL--LPAPQNRTE----PLRCVREIFKSPERLIDLAVILYVDKNTAQGCSDEMALF 392

  Fly   473 ERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSILKCM-VEWSKDLYVNPNMPVPPMQV 536
            ..||:.:.:.|.|..    |.....|.|:: ..:||:|::|..: |..|.:|
  Fly   393 RLLVDAMEECAYGAS----GGGSATEASLQ-ASVECMVALLDSLQVLCSGEL------------- 439

  Fly   537 QSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQLQD--------------LP----EALEERKMRK 583
                 ||...:|..:|.        :|...:.|:|              ||    :|:.|  .|:
  Fly   440 -----TESMISDQIVQV--------VNGRHDLLKDADYSGPLTYQSMARLPAPYRDAIVE--FRQ 489

  Fly   584 EVMET--GIELFNRKPQKGVQFLQEKQLLGATCGDIA-------------------RWLHEDERL 627
            .|.||  |.| ...:||      .|:.......||..                   ||.:  ..|
  Fly   490 TVFETSSGSE-SEGEPQ------HEQDAASNGSGDTEGPEDDDPSSSSDETSRVENRWPY--SHL 545

  Fly   628 DKTVIGNYIGENDDHSKEVMCAYIDAFDF----RQMEVVAALRFLLEGFRLPGEAQKIDRLMEKF 688
            :..|:.  |..:.|:.::      .|.||    ||..|...||.        ....::|..|::|
  Fly   546 EAPVMP--IRTDSDNDRQ------HARDFARALRQDLVPKLLRL--------RSCVELDEAMQEF 594

  Fly   689 ASRYCECNPKNQLFQ---------SADTVYVLAFSIIMLTTDLH--------SPQVKHK-----M 731
            ||..|:.|..|  |.         :||.:|:..:|.::|:..|.        :..:.||     |
  Fly   595 ASAVCQENSMN--FSDFDYNLTAINADGIYLAIYSSLLLSLQLMRAGFYEQVAQGMSHKDILVPM 657

  Fly   732 TKEQYIK--MNRGISDSKSDLPEEYLSS-----IYDEISEHEIKMKNNSGMLQQAKPTGKQAFIT 789
            :::|::.  .|.|:.        .||||     :|..::...:........|:...|
  Fly   658 SEQQFVTSVQNTGVL--------VYLSSPWLCELYQSVTVCNVLEAMPRQQLEGMGP-------- 706

  Fly   790 EKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEH--------------VRPMFKMAWT 840
               |..|.:|..:...|.||.::.....:::  .:.||.|.              .|.:....|.
  Fly   707 ---RCALVDMLCDAGGLGATQMLSEWQRLQT--ANVKHKEEEQLHDKRREAAKKLCRRLLTCCWD 766

  Fly   841 PFLAAFSVGLQD--------------------------CDDPEIATLCLDGIRCAIRIACIFHMS 879
            ..:...|.||.|                          .:...:..:||||:..|..::...::.
  Fly   767 SMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYAMCLDGLHSAATLSNSLNLQ 831

  Fly   880 LERDAYVQALARFTLLNANSPINEMKAKNIDTIKT--LIMVAHTDGNYLGSSW---LDIVKCISQ 939
            ......:..||......:...|:..:|.::|.:.|  |.:     |:|....|   ..:.:.:||
  Fly   832 HLAGKILNLLASNVCQTSGPRISASQAMSMDVVLTGGLNL-----GSYSADCWPSIFAVCRHVSQ 891

  Fly   940 LE----------LAQLIGTGVRP----QFLSGAQTTLKDSLN-PSVKEHIGET------------ 977
            ||          ::...|:..|.    :.||....  :|.|| .|:.....||
  Fly   892 LEHEIFSMQNPAISASPGSSRRDLETGEKLSNGNA--QDKLNLSSIPIDDDETCVDVYSFLQAPM 954

  Fly   978 -SSQSVVVAVDRIFTG----------------------SMRLDGDA--------IVDFVKALCQV 1011
             |..:.:.::.::::|                      :..|.|||        :..|:|.||:.
  Fly   955 QSPNTNITSILKVYSGTNETVLLSQSDTSKVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRA 1019

  Fly  1012 SVDELQQQQ---------------------PRMFSLQKI--VEISYYNMERIRLQWSRIWQVLGE 1053
            |.|:|.:.|                     |....|.:|  |.:..:...|..|...::|.:.|.
  Fly  1020 SRDQLYKSQVARKGSRIWWPSKGWKKLDSLPMSLLLHRIGDVTLKVFRSSRPLLHVLKVWAITGP 1084

  Fly  1054 HFNAVGCNSNEEISFFALDSLRQ-LSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVV 1117
            |.....|:.:..||..|::.:.. ::...:|:.|...|.|.:..|:|||:::..:....::|.:|
  Fly  1085 HLMDAACHRDRMISKRAIEYIHDIITALLVEQSELPYFHFNEALLKPFENLLSMDTDVDVQDQIV 1149

  Fly  1118 RCIAQMVNSQAHNIRSGWKNIFSIFHLAAGD--NEEPIVELAFQTTGKIIGDLYKRQFAIMVDSF 1180
            .|:.::|.:....|||||:.:|.....|...  |...|:::                |.:.:||.
  Fly  1150 ACLYEVVEAHRTEIRSGWRPLFGTLRNARSRMLNMSNIIDI----------------FRVFLDSD 1198

  Fly  1181 Q---------DAVKCL---------------------------------SEFATARFPDTSMEAI 1203
            .         |.:.||                                 .|..|.|..|...|.:
  Fly  1199 NTLVFANAGLDCILCLLSYLEISGGGNNNACSGGSGSAAGGTASNGGQQEEDNTFRPTDFLHETL 1263

  Fly  1204 RLVRTCAQC---VHEAPQLFAEH-------------------AGMEN------------------ 1228
            |.:..|:..   :|..|:....|                   :.|||
  Fly  1264 RFLERCSSILGFMHSMPKCPNFHSTYKIKGISYTHIIDANIPSSMENFTYFGNDYLQTRNEQYMI 1328

  Fly  1229 -----------DASVAEEDRV--WVRGWFPMLFSLSCVVNRCKLDVRTRALTVLFEIVKTY---- 1276
                       ...:.|.|:.  .::.||.:|..|:..:..|....:...|..:|::.|..
  Fly  1329 SYRSLHIDKDTIVKIDEMDKPSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNLLASP 1393

  Fly  1277 GESFKPHWWKDLFNVIFRIFDNMKLP------EHVTEK-SEW------------MTT-------- 1314
            |..|.           |...:::.:|      .::.:. |.|            |||
  Fly  1394 GIDFG-----------FYCINHLLVPMIQDWLRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIE 1447

  Fly  1315 ----------------------TCNHALYAIIDV-----------------------FTQYFD-- 1332
                                  ..::.||:.:..                       :||.:|
  Fly  1448 KSVPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTERIEREQQQQQSPSVQDHGCGYTQQYDSS 1512

  Fly  1333 ----------------------------VLGH--LLLEELFAQLHWCVQQSNEQLARSGTNCLEN 1367
                                        :.|.  |.|::|...|..|..||.|.:||...:||::
  Fly  1513 SSSASEEQQKNGGGVGGGGSNLIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKH 1577

  Fly  1368 LVISNGFKFNESTWDKTCQ-----CILDIFNATLPQDLLSWRPKAHS----SNNIPQEHNHFEAL 1423
            :::|.|..||||.|...|.     |.:.|  |.|.|...::..|::|    ..|:........:|
  Fly  1578 VILSTGMLFNESQWMIACSAIHRACTVTI--APLRQLSFAFHEKSNSFYGDCANVKVAARRDSSL 1640

  Fly  1424 HIRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQLLECQREEQGMYGYLR 1488
            .     :|..|..:...||. :.:::|..:..|...       |.||     |:..:...|.:|
  Fly  1641 E-----ELARIYALAQQVFL-SDNQREPGQNQAPTP-------SASQ-----CKLSDDRSYSFL- 1686

  Fly  1489 TRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQE---------TSSLACVL 1544
                         .:.....||::.|  :.:.|..||..|...|..|.         .|.|.||.
  Fly  1687 -------------LYPLNNGFNSNLD--NFVIRIPFKNLVVGLLANQMLLQLVAKLLLSRLKCVP 1736

  Fly  1545 R----IFFKMYG----------DENRRSDWPGIEQELVQVCKEALGYYLSLQSEAHRDAWTSLLL 1595
            :    ..|..|.          |.:.||      :|::..|.:..     |.|....|:...|..
  Fly  1737 QAVSTCIFDNYAASAASPSHDYDLDFRS------KEILLRCVKQY-----LMSALEFDSRPGLKF 1790

  Fly  1596 LILTRLLKMSDARFATHVSN--------YY-----SLLCEMMCFDLKPE 1631
            |    :.|:|:..:|.::..        ||     |.|.:::.::|.||
  Fly  1791 L----MQKVSNIEYAANLYKQMTSSWMIYYIALVDSHLNDIVVYNLGPE 1835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	353/2052 (17%)
		DCB	30..212	CDD:292830	21/183 (11%)
		Sec7_N	312..465	CDD:289549	34/186 (18%)
		Sec7	582..767	CDD:279680	51/238 (21%)
		DUF1981	1080..1161	CDD:286414	21/82 (26%)
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	58/285 (20%)
CG5937	NP_001096888.2	DUF1981	1115..>1179	CDD:286414	19/63 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030