DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec71 and CYTH4

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_037517.1	Gene:	CYTH4 / 27128	HGNCID:	9505	Length:	394	Species:	Homo sapiens

Alignment Length:	206	Identity:	96/206 - (46%)
Similarity:	135/206 - (65%)	Gaps:	5/206 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 DLPEALEERKMRKEVME--TGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIG 633
            |..|:.||.:|.::..|  .|.:.||..|.||:|:..|.:||.....||||:|::.|.|:||.||
Human    48 DCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIG 112

  Fly   634 NYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPK 698
            .|:||.|..:.:|:.|::|..:|..:.:|.|||..|..||||||||||||:||.||:|||.|||
Human   113 TYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNP- 176

  Fly   699 NQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEIS 763
             .:|||.||.|||:||||||.|.||:|.|:.:...|:::.|||||::. |||||:.|.:::|.|.
Human   177 -GVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNG-SDLPEDQLRNLFDSIK 239

  Fly   764 EHEIKMKNNSG 774
            .....:..:.|
Human   240 SEPFSIPEDDG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	96/206 (47%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	90/186 (48%)
		DUF1981	1080..1161	CDD:286414
CYTH4	NP_037517.1	Sec7	61..243	CDD:279680	90/184 (49%)
		PH_GRP1-like	258..376	CDD:269954
		PH	262..374	CDD:278594
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	268..275
		C-terminal autoinhibitory region. /evidence=ECO:0000250	386..394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810