Protein Alignment Sec71 and sec71

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: NP_594954.1
• Gene: sec71 / 2543610
• PomBaseID: SPAC4D7.01c
• Length: 1811
• Species: Schizosaccharomyces pombe
• Alignment Length: 1837
• Identity: 563/1837 - (30%)
• Similarity: 876/1837 - (47%)
• Gaps: 350/1837 - (19%)

  Fly     3 NNSTKTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALP 67
            |:.....::|::.|.:.:...|..:|  |.:|:            |.|:..||    ||......
pombe   125 NSGKLNPQLFVIEAFKHMSKAKATKR--HKKLR------------EAINNVQI----ELQKQPFL 171

  Fly    68 LPKNDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHL-LIDR 131
            ||          |....|..:||::.|..::...|||..|||.|.:..   ..:.||..: |::|
pombe   172 LP----------EVILEPLVMACQTNSTTLLTITLDCFAKLIDYNYFD---SPTLNPSDITLMER 223

  Fly   132 IVVTIYGCFSGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTA 196
            :|.||..||.|..|.|.|||||:||||..:||:...|....||.|||..|:|:|..|:...|..|
pombe   224 VVNTIASCFCGESTPERVQLQIVKALLAAITSERTIIRHSFLLTAVRQTYNIFLLCKDSTTQAIA 288

  Fly   197 RATLTQMLNVIFARME---NQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDSDEVIASELLAEI 258
            :..|.||::.:|.|:.   |...|....|.|.::.       ||:.:.    ::..|.|:|....
pombe   289 QVALLQMVDSVFQRLSTVLNHEREFSTINMNKSSS-------NGTPDR----ANSPIPSQLSENK 342

  Fly   259 ISAAYNEAMKDQESVGEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFLVFRAL 323
            ::....|..|..:.|.|..|.          :.||:|..              |.:||||:.|||
pombe   343 LTLESFEHRKSFDQVREEAPL----------EEDSLEQQ--------------LLRDAFLLIRAL 383

  Fly   324 CKLSMKPLPDGHP-DPKSHELRSKVLSLHLL-------LLILQNAGPVFRSNEM----FIMAIKQ 376
            ||||:|.:|..|. |.||..:|||::||||:       :.||.:.....||...    .|.|:||
pombe   384 CKLSIKNIPYEHEYDLKSQSMRSKLMSLHLIYHILRTYMNILSDINVKIRSPTSTPTPLIDAVKQ 448

  Fly   377 YLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFEHKWMV 441
            |:|:||:.|.||.|..|||:|..||..:||..|...|.::||||.|||..|||..:||.:.|.::
pombe   449 YICLALAKNVVSHVLPVFEISCEIFWLILSELKNFFKSELEVFFTEIFFPILEMRTSSNQQKIVL 513

  Fly   442 IQALTRICADAQSVVDIYVNYDC-DFSAANLFERLVNDLSKIAQGR------------------- 486
            :....|:|.:.|:::::|:|||| ..:..|::||.:..||:||...
pombe   514 LNIFHRMCEEPQTLIELYLNYDCISGNTENIYERAIVTLSRIASQSTSDPPPSFVFRDDQLVIDK 578

  Fly   487 --------------QALELGA------NPMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPV 531
                          .:..:|:      .|..:..:|::...||:|.|..:..|....:. |.:.:
pombe   579 PGFVYHTLNDIPQLNSSTIGSYVHSHNPPYFDYQIRLKSYRCLISTLSSLFTWCNQTFA-PTVEI 642

  Fly   532 PPM--QVQSPTSTEQDQ---ADTTIQTMHSGSSHSLNSNQEQL-QDLPEALEERKMRKEVMETGI 590
            ...  :.:|.:..|:.|   ::.....::|.|..:|.|:.:.| .|.|...|..|.||:.::..|
pombe   643 TAKDDETESTSKGEEPQKSKSEPPSAGINSTSMDNLESSGQALATDDPSQFENLKHRKKQLQEAI 707

  Fly   591 ELFNRKPQKGVQFLQEKQLLGA-TCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAF 654
            :.||.||::|::.|.....:.: |..|||::|...|.|||.|:|.|:||.:|.:..:|.:::|..
pombe   708 QKFNYKPKEGIKILLSSHFIASKTPTDIAKFLISTEGLDKAVLGEYLGEGNDENIAIMHSFVDHM 772

  Fly   655 DFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLT 719
            .|..:..|.|||..|:.||||||||||||.|.|||.:|.:.|  ..:|::|||.|:||:|||||.
pombe   773 SFNDIPFVNALRSFLQKFRLPGEAQKIDRFMLKFAEKYIDDN--LGVFKNADTAYILAYSIIMLN 835

  Fly   720 TDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNN------------ 772
            |||||||||::||.:.:||.|||:.|. ::|.:.:|:.:|:||.::||.:|:.
pombe   836 TDLHSPQVKNRMTCQDFIKNNRGVDDG-ANLSDSFLTEVYEEIQKNEIVLKDEQDPTSNFPEIPG 899

  Fly   773 ------SGMLQQAKPT--------------GKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSH 817
                  :..:..|..|              .|.|..||...|.|...:.|...|:..::
pombe   900 TSNLSFAANISNALATVGRDLQREAYYMASNKMANKTEALFKDLIREQRERGKLSGNDI------ 958

  Fly   818 VKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLER 882
                :.:|:|.|||.|||:..|.|.|||||..||...||.:..|.|||.|.|:.:...|.|.|.|
pombe   959 ----YYTARHFEHVCPMFEAVWMPILAAFSEPLQLSSDPALIQLSLDGFRLAMNVIFFFSMDLPR 1019

  Fly   883 DAYVQALARFTLLNANSPINEMKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIG 947
            :|::|.|.:||.||..|   |:|..|:..:|||:.::...|:.|..||.|::.||||||..|||.
pombe  1020 NAFMQTLTKFTHLNNTS---ELKWTNMHALKTLLEISLAHGDKLRDSWKDVLLCISQLERVQLIS 1081

  Fly   948 TGVRPQFLSGAQTT--LKDSLNPSVK----------------------------EHIGETSSQSV 982
            .||....|....||  |:.||:.:::                            |.:.|.||:.|
pombe  1082 AGVDINSLPDVSTTKPLRKSLDKNIRQSRSGSISLKHSKSFQSASTHSTKSSSVEIVREYSSREV 1146

  Fly   983 VVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDE----LQQQQPRMFSLQKIVEISYYNMERIRLQ 1043
            |:|||.:|:.:..|..:.|.||||||.:||.:|    |:...||:|||||:||||||||.|||::
pombe  1147 VMAVDMLFSNTRNLGSEGIYDFVKALIEVSWEEIECSLELSNPRLFSLQKLVEISYYNMRRIRME 1211

  Fly  1044 WSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNA 1108
            ||.||.:||.:|..|.|:.|..|:.||||||||.||:|:|..|.|:|:||||||:||.|.|:.:.
pombe  1212 WSSIWSLLGTYFTQVSCHENSIIASFALDSLRQFSMQFLEIEELSHFKFQKDFLQPFSHAMENSQ 1276

  Fly  1109 SPAIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQF 1173
            ...|:|:|:|||.||:.::..||||||:.||.|  ||.....|.:  |..|....::..|.....
pombe  1277 DLKIKDLVLRCIDQMIKARYQNIRSGWRTIFHI--LAYASKIENL--LVLQCAISVVSSLGHEHI 1337

  Fly  1174 AIMV--DSFQDAVKCLSEFA----TARFPDTSMEAIRLVRTCAQCVHEAPQLFAE------HAGM 1226
            :.::  .::.|.:.|:::||    ..:|             |..||.....|..|      |...
pombe  1338 SCVLTQGAYIDLISCITKFAKLNGNQKF-------------CLSCVDMLKNLEHELIKHLKHMKK 1389

  Fly  1227 ENDASVAEEDRVWVRGWFPMLFSLSCVVNRCK---LDVRTRALTVLFEIVKTYGESFKPHWWKDL 1288
            |:..|...|:..|:    |.|.|.:.::  |:   |:||::||.|||:.:..:.:.|...:|:.:
pombe  1390 ESVYSKKLEEEYWL----PFLLSFNEII--CEASDLEVRSKALKVLFDCLYRHADDFDEEFWETV 1448

  Fly  1289 FN----VIFRIF-----DNMKLPEHVTEKSEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFA 1344
            .|    .||.|.     ..:.|.::..|...||.||...||.|.|::....|:.| |.||.:...
pombe  1449 SNKALLSIFSILSITNSQRLYLAKNTEETEVWMLTTMVEALKAFIELIKNLFERL-HFLLPKALN 1512

  Fly  1345 QLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDIFNATLPQDLL-------- 1401
            .|..|:.|.|..:::.|.:|....|:.|..:|.:..||:....|..:...|||.:|.
pombe  1513 LLEKCICQENSMISKVGLSCFSQFVLKNKNQFKDVDWDEIINSINQLLQMTLPIELRDPSLYPQV 1577

  Fly  1402 ------------SWRP----KAHSSNNIPQEHNHFEALHIRCVVQLELIQTMDNIVFFPATSRKE 1450
                        |:||    :.:|.:....:.:|.:::.::|.:||
pombe  1578 NSDSSLEDVKENSFRPHEISRFNSQSVFKSKKHHLKSIVVKCTLQL------------------- 1623

  Fly  1451 DAETLAQAAADLTGGRSGSQSQLLECQRE---EQGMYGYLRTRQLLTLADCLMQSHRFAKRFNAD 1512
                                 .:|.|..|   ...|...:..|:::.|.|.|.||..||:.||:|
pombe  1624 ---------------------LMLNCLWELFHSDNMLTNIPKRKMVKLLDILKQSWEFAESFNSD 1667

  Fly  1513 HDQRSLLWRAGFKGSVKPNLLKQETSSLACVLRIFFKMYG-DENRRSDWPGIEQ--ELVQVCKEA 1574
            .:.|:.:..:|....: ||||.||.   .|....|:..:. ..:.:||....|:  :|:.|.::.
pombe  1668 FEIRAKILSSGIVEHM-PNLLSQEA---LCAKLYFYTAFECMSSLKSDSHDTEEYNDLMDVFQKK 1728

  Fly  1575 LGYYLSLQSEAHR-------------DAWTSLLLLILTRLLKMSDARFATHVSNYYSLLCEMM-C 1625
            :  ||:.|...|.             .|:..::..:::.:..:.:.:|:...|.:|.|||.:: |
pombe  1729 I--YLASQLVLHGFQRVIGDNPVKGVAAFQPVIAALVSYINSLDEIQFSRGKSEFYQLLCAIVAC 1791

  Fly  1626 FDLKPELRSVLRRVFMR 1642
            ..:..:|.:.|...|:|
pombe  1792 GHIDQQLGTSLSNAFLR 1808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	546/1749 (31%)
		DCB	30..212	CDD:292830	62/182 (34%)
		Sec7_N	312..465	CDD:289549	72/165 (44%)
		Sec7	582..767	CDD:279680	84/185 (45%)
		DUF1981	1080..1161	CDD:286414	37/80 (46%)
sec71	NP_594954.1	DCB	110..304	CDD:292830	67/209 (32%)
		Sec7_N	372..536	CDD:289549	70/163 (43%)
		COG5307	380..1562	CDD:227623	416/1222 (34%)
		Sec7	699..882	CDD:279680	84/185 (45%)
		DUF1981	1248..1331	CDD:286414	37/86 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	230	1.000	Domainoid score	I504
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	739	1.000	Inparanoid score	I86
OMA	1	1.010	-	-		QHG54931
OrthoFinder	1	1.000	-	-		FOG0001583
OrthoInspector	1	1.000	-	-		otm47243
orthoMCL	1	0.900	-	-		OOG6_100729
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1314
SonicParanoid	1	1.000	-	-		X714
TreeFam	1	0.960	-	-
	13	12.860