DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sec71 and PSD4

DIOPT Version :9

Sequence 1:NP_609675.2 Gene:Sec71 / 34785 FlyBaseID:FBgn0028538 Length:1653 Species:Drosophila melanogaster
Sequence 2:NP_036587.2 Gene:PSD4 / 23550 HGNCID:19096 Length:1056 Species:Homo sapiens


Alignment Length:309 Identity:73/309 - (23%)
Similarity:127/309 - (41%) Gaps:63/309 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 PVPPMQVQS-----PTSTEQDQADTTIQTM-HSGSSHSLNSNQEQLQDLPEALEERKMRKEVMET 588
            |.|..:|:|     |..|...|.|..:.:. |......:||:......:|:|             
Human   512 PKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQA------------- 563

  Fly   589 GIELFNRKPQKGVQFLQEKQLLGATCGDIARW-----LHEDERLDKTVIGNYIGENDDHSKEVMC 648
                  :.|::|.:.....:|......:...|     |:..|...|:.:..|:.:|:|.|:.|..
Human   564 ------QSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAE 622

  Fly   649 AYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAF 713
            .|:..|.|....:..|||..|:...|.||.|:.:|::.:|:.|:..|||  .:|.|.|:|:.|..
Human   623 EYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNP--GIFPSVDSVHTLTC 685

  Fly   714 SIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKM--------- 769
            :|::|.||||...:...|:.:::|....|:.|. .:.|:|.|.::|..|...:::.         
Human   686 AIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDG-GNFPKELLKALYWSIRSEKLEWAVDEEDTAR 749

  Fly   770 -----------KNNSGMLQQAK----PTGKQAFITEKR------RKLLW 797
                       |.:...||.|:    ||.||..:..|.      :|..|
Human   750 PEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPW 798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec71NP_609675.2 PLN03076 13..1580 CDD:215560 73/309 (24%)
DCB 30..212 CDD:292830
Sec7_N 312..465 CDD:289549
Sec7 582..767 CDD:279680 49/189 (26%)
DUF1981 1080..1161 CDD:286414
PSD4NP_036587.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..71
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..149
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..239
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 340..362
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..533 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..581 7/53 (13%)
Sec7 570..738 CDD:238100 47/170 (28%)
PH_EFA6 772..900 CDD:270107 7/27 (26%)
PH 794..892 CDD:278594 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1004..1056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148877
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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