DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and Psd3

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_036009810.1	Gene:	Psd3 / 234353	MGIID:	1918215	Length:	1303	Species:	Mus musculus

Alignment Length:	1217	Identity:	223/1217 - (18%)
Similarity:	401/1217 - (32%)	Gaps:	410/1217 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQD-SANPGHLLIDRIVVTIYGCF--SGPQT 145
            ||.:|.|:..||                   ..::.| :::|......|.|::.:|..  ..|:.
Mouse   138 LPQQLPCRLASP-------------------APTLNDRNSSPSIGWKHRPVISAHGDLWDMDPEA 183

  Fly   146 DEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQ------------TTARA 198
            ..|::..:.::.|:....:....                |..:..|||            ||..|
Mouse   184 RNAIEFSVPQSTLSYAADRGKRA----------------LQRRGTVNQEVLPKNCEEDIGTTVLA 232

  Fly   199 TLTQMLNVIFARMENQVYELPPPNSNP---------TNGSIHSEDCN--------GSGEESLRDS 246
            |..|:.........:|.. |.||.:.|         .:.|.||:...        |..||...||
Mouse   233 TRAQLFRYCPTIQISQSC-LAPPAAVPLKAEPFVWVNSASAHSQSVAKAKYEFLFGKSEEKTPDS 296

  Fly   247 DEVIASELLAEIISAAYNE------------AMKDQESVGEP--------EPTLNGNDYSSHS-- 289
            .:...|.||...::..:.|            |..|.::...|        ...|.|.|...:|
Mouse   297 SDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASLDFDAKSPPCRLPGQQAVHLLAGQDSILNSVT 361

  Fly   290 --DHDSVELHSEN------DAVVTA-------------KFTHILQKDA----FLVFRALCKLSMK 329
              .:|:.:.|.:.      |::::|             :.|.:|.|||    :.|.:.|...|.|
Mouse   362 EGPNDAPQCHPQEQSLQPIDSLISALKATEARIASGTFQATKVLDKDANFSVYQVDKELSTASHK 426

  Fly   330 PL---------PDGHPD-PKSHELRSKV-LSLHL---LLLILQNAGPVFRS-----NEMFIMAIK 375
            |.         |...|| |.|.|:.::. ||||:   |..:|.......||     .....:.:.
Mouse   427 PQRAHRTFPVGPGKSPDIPLSAEVPTEENLSLHIQEDLSALLPEEAQAHRSQITNYRRQGPLRVP 491

  Fly   376 QYLCVALSNN----------------------------------------------GVSLV---- 390
            :..|...|::                                              ||.::
Mouse   492 ESACPVSSSSAGSHNPVDRVGALREQRSDLGREHPRGYDRGGSMGRQGRIKHVEFQGVEILWTGE 556

  Fly   391 -------PEVFELSLSIFVAL----------LSNFKVHLKRQI---------------------- 416
                   ||.....:|...|.          :.:...||...:
Mouse   557 EAESRHPPERTASPVSKEFAKRPSHSSPACGVCSTSTHLTGDVWDETCKAPSERPGTSAGTLSPM 621

  Fly   417 --------EVFFKEIFLNILEANSSSFEHKWMVIQALTRICAD--------AQSVVDIYVNYDCD 465
                    :||.:| ....||.|.:....|..::.....:..|        .:...|:|
Mouse   622 PLGESGEDDVFLRE-SKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDVY------ 679

  Fly   466 FSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMP 530
               ::.||.::::.|        |...|          ..||.|.|        ..|.|.:..||
Mouse   680 ---SSQFETILDNTS--------LYYSA----------ESLETLYS--------EPDSYFSFEMP 715

  Fly   531 VPPMQVQSPTSTEQDQADTTIQTMH----------------SGSSHSLNSNQEQL-----QDLPE 574
            :.||..|......|....|::...|                :|.::.|:.:...:     |::..
Mouse   716 LTPMIQQRIKEGGQFLERTSVGGQHDVLSVSADGGIVMGYSAGITNGLHDSANSVYTRGPQEIAF 780

  Fly   575 ALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQ----LLGATCGDI------ARWLHEDERLDK 629
            .....:...|...||::..:   :.|...:.||:    |...|..::      |:.|:..:|..:
Mouse   781 WGSRDRCFAEGKTTGVDAGS---EMGSTDILEKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKR 842

  Fly   630 TVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCE 694
            :.:..::|:|::.||.|...|:..|||..|.:..:||:.|:.|.|.||.|:.:|::..|::||..
Mouse   843 SDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFS 907

  Fly   695 CNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIY 759
            |||  ....|.|.|:.|..::::|.||||...:..|||.:::|...:|:::. .|..::.|.::|
Mouse   908 CNP--DTITSKDGVHCLTCAMMLLNTDLHGHNIGKKMTCQEFITNLQGVNEG-GDFSKDLLKALY 969

  Fly   760 DEI---------SEHEIKMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISL--TATNLMQ 813
            :.|         .:.|.|...:.|..::|..|                 ..:.||.  :.||...
Mouse   970 NSIKNEKLEWAVDDEEKKKSPSEGTDEKANGT-----------------HPKTISRIGSTTNPFL 1017

  Fly   814 SVSH------VKSPFTSAK-HLE---HVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRC 868
            .:.|      .||.|.:.| |.:   ...|..|..|..|.|...           .|:
Mouse  1018 DIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLK-----------GTV------- 1064

  Fly   869 AIRIACIFHMSLERDAY--VQALARFTLLNANSPINEMKAK--------NIDTIKTL---IMVAH 920
                     :.|::|.|  .::|:...|.||.|..:.:.:|        |:..:||.   :::..
Mouse  1065 ---------LYLQKDEYKPEKSLSDEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQ 1120

  Fly   921 TDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLS--GAQ----------TTLKDSLNPSVKEH 973
            |........|::.:.|::.:..|        |.|.:  |:|          ||.|.|....:|.|
Mouse  1121 TQSPEEMQGWINKINCVAAVFSA--------PPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH 1177

  Fly   974 IGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQQQ 1020
            ..:....:..:|..|.:....::....:.::......:..:.|.|.|
Mouse  1178 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFESLGQNQ 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	223/1217 (18%)
		DCB	30..212	CDD:292830	23/142 (16%)
		Sec7_N	312..465	CDD:289549	43/280 (15%)
		Sec7	582..767	CDD:279680	54/203 (27%)
		DUF1981	1080..1161	CDD:286414
Psd3	XP_036009810.1	Sec7	823..977	CDD:238100	46/156 (29%)
Psd3	XP_036009810.1	PH_EFA6	1022..1147	CDD:270107	28/159 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810