DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and PSD3

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_016868747.1	Gene:	PSD3 / 23362	HGNCID:	19093	Length:	1067	Species:	Homo sapiens

Alignment Length:	1067	Identity:	214/1067 - (20%)
Similarity:	366/1067 - (34%)	Gaps:	316/1067 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 ANPGHLLIDRIVVTIYGCFSG--------------PQTDEAVQ--LQIIKALLTVVTSQHVEIHE 170
            |.|.|....:.|..:.||.||              |......:  ||.|.:|::.:.:....|..
Human   103 ALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQSHLKEQSLQPIDSLISALKATEARIIS 167

  Fly   171 FTLLQAVRTCYDIYLSS---KNLVNQTTARATLTQMLNVIFARMENQVYELPPPNSNPTNGSIHS 232
            .| |||.:......:||   :.:..:....:..||.:|......:..:.|:|......|
Human   168 GT-LQATKVLDQDAVSSFSVQQVEKELDTASRKTQRVNKTLPAGQKNLPEIPLSAEVTT------ 225

  Fly   233 EDCNGSGEESL-----RDSDEVIASELLAEIISAAYNEAMKDQESVGEPEPTL------------ 280
                   |||.     :|...::..:..|| ||...|...|....|.||...|
Human   226 -------EESFYLSIQKDLTALLTGDTQAE-ISQIMNNGRKGAVCVQEPSCPLASLGSSAVTCHS 282

  Fly   281 -------------------NGNDYSS---------HSDHDSVEL----HSENDAVVTAKFTHILQ 313
                               .|.|.||         |.:...||:    ..:.:......|...||
Human   283 AGSVGFLKEQRSALGREHPGGCDRSSSMGRPGRVKHVEFQGVEILWTGGDKRETQHPIDFETSLQ 347

  Fly   314 KDAFLVFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYL 378
            :.|                  .||.|    .|..:..||    :.:||                |
Human   348 RTA------------------SPDSK----ESSKVPRHL----ISSAG----------------L 370

  Fly   379 CVALSNNGVSLVPEVFELSL-------SIFVALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFE 436
            |     |..||...|::.|.       .......|..::....:.|||.:|        |....|
Human   371 C-----NSSSLTENVWDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQE--------NKQHLE 422

  Fly   437 HKWMVIQALTRICADAQSV----------------VDIYVNYDCDFSAANLFERLVNDLSKIAQG 485
            ......:...||....:.|                .|:|         ::.||.::::.|
Human   423 KTPKPERDRERISEQEEHVKGEDEDILGPGYTEDSTDVY---------SSQFETILDNTS----- 473

  Fly   486 RQALELGANPMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPVPPM---------QVQSPTS 541
               |...|          ..||.|.|        ..|.|.:..||:.||         |....||
Human   474 ---LYYSA----------ESLETLYS--------EPDSYFSFEMPLTPMIQQRIKEGGQFLERTS 517

  Fly   542 --TEQD----QAD-TTIQTMHSGSSHSLNSNQEQL--QDLPEALEERKMRKEVMETGIELFNRKP 597
              ..||    .|| ..:....||.::.||...:.:  :..|| :........|..|.:|..:
Human   518 GGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPE-IAFWGSNAGVKTTRLEAHS--- 578

  Fly   598 QKGVQFLQEKQ----LLGATCGDI------ARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYID 652
            :.|...:.||:    |...|..::      |:.|::.:|..::.:..::|:|::.||.|...|:.
Human   579 EMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLK 643

  Fly   653 AFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIM 717
            .|||..|.:..:||:..:.|.|.||.|:.:|::..|::||..|||  ....|.|.|:.|..:|::
Human   644 FFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNP--DTIASQDGVHCLTCAIML 706

  Fly   718 LTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKPT 782
            |.||||...:..|||.:::|...:|:::. .|..::.|.::|:.|...:::...:.   ::.|.:
Human   707 LNTDLHGHNIGKKMTCQEFIANLQGVNEG-VDFSKDLLKALYNSIKNEKLEWAVDD---EEKKKS 767

  Fly   783 GKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSH------VKSPFTSAK-HLE---HVRPMFKM 837
            ..::  ||::........:..|..| ||....:.|      .||.|.:.| |.:   ...|..|.
Human   768 PSES--TEEKANGTHPKTISRIGST-TNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKR 829

  Fly   838 AWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAY--VQALARFTLLNANSP 900
            .|..|.|...           .|:                :.|::|.|  .:||:...|.||.|.
Human   830 GWKTFYAVLK-----------GTV----------------LYLQKDEYKPEKALSEEDLKNAVSV 867

  Fly   901 INEMKAK--------NIDTIKTL---IMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQF 954
            .:.:.:|        |:..:||.   :::..|........|::.:.|::.:..|        |.|
Human   868 HHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSA--------PPF 924

  Fly   955 LS--GAQ----------TTLKDSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDG--------- 998
            .:  |:|          ||.|.|....:|.|..:....:..:|..|.:....::..
Human   925 PAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLK 989

  Fly   999 DAIVDFVKALCQVSVDELQQQQPRMFS 1025
            |..::|.|...::.|..|::....:.|
Human   990 DHYLEFEKTRYEMYVSILKEGGKELLS 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	214/1067 (20%)
		DCB	30..212	CDD:292830	23/108 (21%)
		Sec7_N	312..465	CDD:289549	30/175 (17%)
		Sec7	582..767	CDD:279680	54/194 (28%)
		DUF1981	1080..1161	CDD:286414
PSD3	XP_016868747.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740