Protein Alignment Sec71 and MON2

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: XP_016874530.1
• Gene: MON2 / 23041
• HGNCID: 29177
• Length: 1718
• Species: Homo sapiens
• Alignment Length: 1502
• Identity: 281/1502 - (18%)
• Similarity: 493/1502 - (32%)
• Gaps: 546/1502 - (36%)

  Fly    16 ALEKILAD--KDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPKNDAASIIN 78
            |::|:|.:  .|: |:...:.||......|..::.:|....||..|....|||   |.:::.::.
Human     9 AVKKLLENMQSDL-RALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAAL---KENSSEVVQ 69

  Fly    79 AETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGCFSGP 143
                  ||.:.|.::.|:|....|..:|:|::  |...|...:.|..::|...:
Human    70 ------PFLMGCGTKEPKITQLCLAAIQRLMS--HEVVSETAAGNIINMLWQLM----------- 115

  Fly   144 QTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIF 208
             .:...:|::::.:|.::|:..| :|:..|.:|:..|:.::.:..|:.|.|.| ||:.|::.|:|
Human   116 -ENSLEELKLLQTVLVLLTTNTV-VHDEALSKAIVLCFRLHFTKDNITNNTAA-ATVRQVVTVVF 177

  Fly   209 ARMENQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDSDEVIASELLAEIISAAYNEAMKDQESV 273
            .||.                   :||      |..||..|
Human   178 ERMV-------------------AED------ERHRDIIE------------------------- 192

  Fly   274 GEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLP---DGH 335
               :|.|             |:.:|...:|.|.|   ...|||:::|:.||:|.....|   .|.
Human   193 ---QPVL-------------VQGNSNRRSVSTLK---PCAKDAYMLFQDLCQLVNADAPYWLVGM 238

  Fly   336 PDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVAL-------------SNNGV 387
            .:      .::...|.||..:|.:...||..::.|...:|:.:|..:             |:...
Human   239 TE------MTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSS 297

  Fly   388 SLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFK------EIFLNILEANSSSFEHKWM---VIQ 443
            |..| |.:....|.:.||....|.:|:    |:.      ||||::|.....:.:.:|:   .::
Human   298 SPAP-VEKPYFPICMRLLRVVSVLIKQ----FYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVE 357

  Fly   444 ALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLEC 508
            ::.|.|...|.:.....:||....:..:|..:||.|....|
Human   358 SIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQ------------------------ 398

  Fly   509 LVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQLQDLP 573
                         .|::     |||  ..:|.::.|      ....:.|.|.|..:|...:
Human   399 -------------SLFL-----VPP--TGNPATSNQ------AGNNNLGGSVSAPANSGMV---- 433

  Fly   574 EALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGE 638
                           ||       ..||..|...:..|.       |:   ..|..||.|:
Human   434 ---------------GI-------GGGVTLLPAFEYRGT-------WI---PILTITVQGS---- 462

  Fly   639 NDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQ 703
                   ....|::..|..:...:.      ||:.:.
Human   463 -------AKATYLEMLDKVEPPTIP------EGYAMS---------------------------- 486

  Fly   704 SADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIK 768
                   :||..:                    :.:.|||:           |.|..|:.|.|.:
Human   487 -------VAFHCL--------------------LDLVRGIT-----------SMIEGELGELETE 513

  Fly   769 MKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRP 833
            .:..:.  :.:.||  |:...:..:.....|:.|::|....                      ..
Human   514 CQTTTE--EGSSPT--QSTEQQDLQSTSDQMDKEIVSRAVW----------------------EE 552

  Fly   834 MFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACI---FHMSLERDAYVQALAR---- 891
            |....|...|||.|: |.|....|.||..:  ::..:.:|.:   ..:...|||::.|:.:
Human   553 MVNACWCGLLAALSL-LLDASTDEAATENI--LKAELTMAALCGRLGLVTSRDAFITAICKGSLP 614

  Fly   892 ----FTLLNAN--------------------SPINE---------------------MKAKNIDT 911
                .|:||..                    ||.:|                     :.:|||..
Human   615 PHYALTVLNTTTAATLSNKSYSVQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQC 679

  Fly   912 IKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQL------------IGTGVRP-QFLSGAQTTLK 963
            ::||:.:||..|..||:||        ||.||.|            .|..::| :.:.|..|.|.
Human   680 MRTLLNLAHCHGAVLGTSW--------QLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLT 736

  Fly   964 DSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDEL-----QQQQPRM 1023
            .::         .|....:...:.|:|..|..||..::...:.|||.:|::.:     ..::|.:
Human   737 TAV---------MTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSL 792

  Fly  1024 FSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGC---NSN-EEISFFALDSLRQLSMKFMEK 1084
            |::.|::|....||.||.:    :|:.|..|.....|   ||. .|....||.||.:..:.|...
Human   793 FAVAKLLETGLVNMHRIEI----LWRPLTGHLLEKVCQHPNSRMREWGAEALTSLIKAGLTFNHD 853

  Fly  1085 GEFS-NFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGD 1148
            ...| |.|.|...|.|.:.:...| .|.||...:.|:.|::.||..::..||..:..:......|
Human   854 PPLSQNQRLQLLLLNPLKEMSNIN-HPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRND 917

  Fly  1149 NEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFATARFPDTSMEAIRLVRTCAQCV 1213
            ..|.::..|||.            ..::|..|...:.|                     ||.|.|
Human   918 QGESLIRTAFQC------------LQLVVTDFLPTMPC---------------------TCLQIV 949

  Fly  1214 HEAPQLFAEHAGMENDASVAEEDRVW-------VRG----------------------------- 1242
            .:....|..| ..|.:.|:.....:|       .||
Human   950 VDVAGSFGLH-NQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPF 1013

  Fly  1243 ---------WFPMLFSLS--CVVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKD-LFNVIFRI 1295
                     |..:...|.  ||..|..  ||..|...||..:..:|...:...|.. ::.|:|.:
Human  1014 HPAPPFDCLWLCLYAKLGELCVDPRPA--VRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHL 1076

  Fly  1296 FDNMK------------------LPEHVTEKSE------WMTT---------TCNHALYAIIDVF 1327
            .|.::                  |..|..:.:|      |:.|         |..:.|..:.| |
Human  1077 LDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGD-F 1140

  Fly  1328 TQYFDVL 1334
            ::.:|||
Human  1141 SRAWDVL 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	281/1502 (19%)
		DCB	30..212	CDD:292830	41/181 (23%)
		Sec7_N	312..465	CDD:289549	39/177 (22%)
		Sec7	582..767	CDD:279680	24/184 (13%)
		DUF1981	1080..1161	CDD:286414	22/81 (27%)
MON2	XP_016874530.1	DCB	9..183	CDD:292830	47/218 (22%)
		Sec7_N	212..379	CDD:289549	39/177 (22%)
		DUF1981	<873..932	CDD:286414	15/71 (21%)
		Mon2_C	935..1709	CDD:292823	40/238 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810