DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec71 and bris-1

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_500420.3	Gene:	bris-1 / 177142	WormBaseID:	WBGene00019726	Length:	640	Species:	Caenorhabditis elegans

Alignment Length:	432	Identity:	112/432 - (25%)
Similarity:	179/432 - (41%)	Gaps:	101/432 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 KWMVIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMR 502
            :||||:       .....:..:::..|..|.:..     |:||  ...|.|..|.|....:::.|
Worm    65 QWMVIR-------HKHDTIPDHLDARCGVSNSQR-----NELS--LTSRYATSLSAQLRIDRAAR 115

  Fly   503 IRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQ---------------------------SPT 540
                             |..|..:|..|.||:.|.                           :|.
Worm   116 -----------------STTLDRSPPSPAPPVLVNLQNSNMIDSLMSPRLGNRRFGAAASRCAPA 163

  Fly   541 STEQDQADTTI--------QTMHSGS------------SHSLNSNQEQLQDLPEALEERKMRKEV 585
            :.|....:..:        ...||.|            |.|.|..::.....|..:.::: ||..
Worm   164 AAELTSTEVWLPRPSLVNHNPAHSNSLPRLDKHRVHERSESSNGRKKSEVKPPRQMTDQE-RKRQ 227

  Fly   586 METGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAY 650
            ....:..||:||::|||.|.....:..:...:|..|.....|.|::||.|||........::..|
Worm   228 YRIALNFFNKKPERGVQLLTAWGFVKNSPDSLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKY 292

  Fly   651 IDA-FDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSA--DTVYVLA 712
            ..| .|.|.:||..|||..::.|.||.||:||||:::.||..|.:.|||.......  ||:::|:
Worm   293 FTALIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLLS 357

  Fly   713 FSIIMLTTDLHSPQVKHKMTKEQYIKMNRG---ISDSKS--DLPEEYLSSIYDEISEHEIK---- 768
            |:||||.||||||.||.:||:..::|..||   ||..|:  |:..:.|..|||.|.:.|:|
Worm   358 FAIIMLNTDLHSPNVKQRMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIYDRIKKDELKAGDD 422

  Fly   769 -----MKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVIS 805
                 .:.:..::.:.||.     :||..|:|:....::.:|
Worm   423 HVAQVQRVDRAIVGKDKPR-----LTETPRRLVCYCRLQQVS 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	112/432 (26%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549	4/26 (15%)
		Sec7	582..767	CDD:279680	73/192 (38%)
		DUF1981	1080..1161	CDD:286414
bris-1	NP_500420.3	Sec7	224..417	CDD:366596	73/192 (38%)
bris-1	NP_500420.3	PH_IQSEC	445..573	CDD:270128	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910