DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec71 and Cyth1

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_446362.1	Gene:	Cyth1 / 116691	RGDID:	620397	Length:	398	Species:	Rattus norvegicus

Alignment Length:	247	Identity:	108/247 - (43%)
Similarity:	153/247 - (61%)	Gaps:	11/247 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 VQSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQLQDLPEAL------EERK--MRKEVMETGIEL 592
            |.|..:.|:.|....|:.........:...:|::.::...:      ||||  .|.:.:..|.:.
  Rat     8 VPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKK 72

  Fly   593 FNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFR 657
            ||..|:||:|||.|..||..||.|||::|::.|.|:||.||:|:||.|:.|.:|:.|:::..:|.
  Rat    73 FNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFT 137

  Fly   658 QMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDL 722
            .:.:|.|||..|..||||||||||||:||.||.|||:||  ..:|||.||.|||:|:||||.|.|
  Rat   138 DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCN--TGVFQSTDTCYVLSFAIIMLNTSL 200

  Fly   723 HSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSG 774
            |:|.||.|.|.|::|.|||||:|. .|||||.|.::|:.|.....|:..:.|
  Rat   201 HNPNVKDKPTVERFIAMNRGINDG-GDLPEELLRNLYESIKNEPFKIPEDDG 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	108/247 (44%)
		DCB	30..212	CDD:292830
		Sec7_N	312..465	CDD:289549
		Sec7	582..767	CDD:279680	96/184 (52%)
		DUF1981	1080..1161	CDD:286414
Cyth1	NP_446362.1	Sec7	62..244	CDD:307500	96/184 (52%)
		PH_GRP1-like	259..379	CDD:269954
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250	269..277
		C-terminal autoinhibitory region. /evidence=ECO:0000250	388..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810