Protein Alignment Sec71 and Gbf1

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: XP_006526643.1
• Gene: Gbf1 / 107338
• MGIID: 1861607
• Length: 1862
• Species: Mus musculus
• Alignment Length: 1871
• Identity: 399/1871 - (21%)
• Similarity: 676/1871 - (36%)
• Gaps: 593/1871 - (31%)

  Fly     9 KEMFIVRALEKILA---DKDIRRSHHSQLKKSCDSAL---EQIKAELISAGQIAEGNELPCAALP 67
            |.::|::....|:.   .::.|.|.|..|.:..|..|   ..:|..|.|..:::|
Mouse     4 KNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFSNLKEVLNSVTELSE---------- 58

  Fly    68 LPKNDAASIINAETYFLPFELACKSRSPRIVVT--ALDCLQKLIAYGHLTGSIQDSANPGHLLID 130
                     |....:..||....:|......:|  ||..:.|.::|..:..:.:.:|.....:.|
Mouse    59 ---------IEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMAD 114

  Fly   131 RIVVTIYGCFSG--PQTDEAVQLQIIKALLTV--------VTSQHV-EIHEFTLLQAVRTCYDIY 184
            .:.   :..|.|  |.:||.|.::|::.|.|:        :|::.| ||    :....|.|:::.
Mouse   115 AVT---HARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI----MQSCFRICFEMR 172

  Fly   185 LSSKNLVNQTTARATLTQMLNVIFARM-----ENQVY---------------------------- 216
            ||.   :.:.:|..||..|:.::|.|:     |.:.|
Mouse   173 LSE---LLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNMKKLKMRAGGMSDSSKWKKQKRSP 234

  Fly   217 -------------ELPPPN-----SNPTNG--------SIHS----------EDCNGSG------ 239
                         |||.||     ||.|.|        ||.|          ..|..||
Mouse   235 RPPRHTTKVTPGSELPTPNGATLPSNLTGGVPFIDAPTSISSASSEAASTVVSPCTDSGLELSSQ 299

  Fly   240 ---EESLRD----------------SDEVIASELLAEIISAAYNEAMKDQESVGEPEPTLNGNDY 285
               :|.|.|                |.|:.||:.|......|:.|..:.......||..   .:.
Mouse   300 TTSKEDLTDLEQAGSPREITTSEPGSSEMGASDQLDPQQEGAHVEKAQSASVESIPEVL---EEC 361

  Fly   286 SSHSDH-DSVELHSENDAVVT--AKFTHILQKDAFL-----------VFRALCKLSMKPLPDGHP 336
            :|.:|| ||..:| :.|.|..  .:||...||:...           :||.|..|:       :|
Mouse   362 TSPADHSDSASVH-DMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLT-------NP 418

  Fly   337 DPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLC----VALSNNGVSLVPEVFELS 397
            ..:.:......:.||||.:.|::| ||.:. :..:..||..:|    ..||...::|    :..|
Mouse   419 HDRHNSEVMIHMGLHLLTVALESA-PVAQC-QTLLGLIKDEMCRHLFQLLSVERLNL----YAAS 477

  Fly   398 LSIFVALLSNFKVHLKRQIEVFFKEIF-LNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVN 461
            |.:...|..:.:.|||.|:|::.|::. :..:|.....:|.|.|.::|:.::......|.::|:|
Mouse   478 LRVCFLLFESMREHLKFQLEMYIKKLMEIITVENPKMPYEMKEMALEAVVQLWRIPSFVTELYIN 542

  Fly   462 YDCDFSAANLFERLVNDLSKIAQGRQALELGANPM--QEKSMRIRGLE------------CLVSI 512
            ||||:..:||||.|...|||          .|.|:  |..:..:..|:            |...:
Mouse   543 YDCDYYCSNLFEDLTKLLSK----------NAFPVSGQLYTTHLLSLDALLTVIDSTESHCQAKV 597

  Fly   513 LKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTT----------IQTMH--SGSSHSLNSN 565
            |..:.:..|.....|....    |.....|.:.:..|:          .:.:|  ||...|....
Mouse   598 LNTLNQQEKKETARPGFEA----VDGNPETNKSERATSDGKSTGVALDARGLHFPSGGWLSTEHG 658

  Fly   566 QEQLQDLPEA-------------------------LEERKMRKEVMETGIELFNRKPQKGVQFLQ 605
            :...:||.||                         |.|.|.:|:::.||.|.||:||:||:||||
Mouse   659 KPGCRDLEEAGDSGADKKFTRKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQ 723

  Fly   606 EKQLLGATCG--DIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFL 668
            ||.||.....  ::|:||.|:.||||.:||.::  :|..:.:::.:::..|.|:.:.:..|||..
Mouse   724 EKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFV--SDRKNMDLLESFVSTFSFQGLRLDEALRLY 786

  Fly   669 LEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHK--- 730
            ||.|||||||..|.||:|.|...:..||  ...|.::|..:.||:::|||.||.|:..|:.:
Mouse   787 LEAFRLPGEAPVIHRLLEVFTEHWRSCN--GSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAP 849

  Fly   731 MTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKM-KNNSGMLQQAKPTGKQAFITEKRRK 794
            ||.|::.|..:|::..| |..::.|..:|..|...||.| :..:|::               |..
Mouse   850 MTLEEFRKNLKGVNGGK-DFEQDILEDMYHAIKNEEIVMPEEQTGLV---------------REN 898

  Fly   795 LLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIA 859
            .:|::           |:...:..:..|.......:...:|.|.|.|.:||.|.......:..|.
Mouse   899 YVWSV-----------LLHRGASPEGVFLRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETII 952

  Fly   860 TLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNIDTI-----------K 913
            ...:.|.|....|:..:.:|...|..:.:|.:||.|::.|      .:|:.::           |
Mouse   953 QKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSES------IENLPSVFGSNPKAHIAAK 1011

  Fly   914 TLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQTTLKDSLNPSVK------- 971
            |:..:||..|:.|...|.:|::.:.||         .|.|.|..|...::|.::|:.|
Mouse  1012 TVFHLAHRHGDILREGWKNIMEAMLQL---------FRAQLLPKAMVEVEDFVDPNGKISLQREE 1067

  Fly   972 --EHIGETSSQSVV-------------------------VAVD--------RIFTGSMRLDGDAI 1001
              .:.||::..|.|                         ||:|        ::.|.|..|..:::
Mouse  1068 TPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESL 1132

  Fly  1002 VDFVKALCQVSVD-ELQQQQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEE 1065
            .:.:|||..|:.| |...::...|.|:.::.|...|.:|:    ..:||.:.:|...: |...::
Mouse  1133 QELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRV----GCVWQTVRDHLYHL-CVQAQD 1192

  Fly  1066 ISFF---ALDSLRQLSMKFMEKGEFS-----NFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQ 1122
            ..|.   |:..|.:|:::.:.:.|.|     :.|...        :||.:....:...|...:.:
Mouse  1193 FCFLVERAVVGLLRLAIRLLRREEISGQVLLSLRILL--------LMKPSVLSRVSHQVAYGLHE 1249

  Fly  1123 MVNSQAHNIRSG--WKNIFSIFHL-----------------------AAGDNEEP---------- 1152
            ::.:.|.||.||  |..:|::...                       |..|:|.|
Mouse  1250 LLKTNAANIHSGDDWATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLD 1314

  Fly  1153 ---------------------------IVELAFQTTGKIIGDLYK--------------RQFAIM 1176
                                       :|...:...||...|..|              .|:::.
Mouse  1315 RGYTSDSEVYTDHGRPGKIHRSATDADMVNSGWLVVGKDDIDNSKPGAGLSRPGPSPLVNQYSLT 1379

  Fly  1177 V-------------------------------DSFQDAVKCLSEFATA----------------- 1193
            |                               |:|:..||.|..|..|
Mouse  1380 VGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQDKRSKSHK 1444

  Fly  1194 ------RFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASV-------------------- 1232
                  ||.....|...|.|......|...   ..|:..|.|..|
Mouse  1445 YDSKGNRFKKKPKEGSMLRRPRGSNQHATR---GGHSDEEEDEGVPASYHTVSLQVSQDLLDLMH 1506

  Fly  1233 -------------AEEDR---------------VWVRGWFPMLFSLSCVVNRCKLDVRTRALTVL 1269
                         |||.|               :|...|.|:|..::|:....:..||.:|||.|
Mouse  1507 TLHTRAASIYSSWAEEQRHLEGGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYL 1571

  Fly  1270 FEIVKTYG-ESFKPHWWKDLFN-VIFRIFDNMKLPEHVTEKS-EWMTTTCNHALYAIIDVFTQYF 1331
            ...:..:. :......|:..|| |:|.:.  .||.|:::... ..|..|...|...:..||.|:
Mouse  1572 QRALLVHDLQKLDALEWESCFNKVLFPLL--TKLLENISPADVGGMEETRMRASTLLSKVFLQH- 1633

  Fly  1332 DVLGHLLLEELFAQLHWCV----------QQSNEQLARSGTNCLEN--LVISNGFKFN------- 1377
              |..||....||.| |..          ..|::.|:.:....|:|  ||:.....|:
Mouse  1634 --LSPLLSLSTFAAL-WLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGG 1695

  Fly  1378 ------ESTWDKTCQCIL-----DIFNATLPQDLLSWRPKAHSSNNIPQEH 1417
                  |.||:: ..|.|     ::|..|:.||.:...|  ||...:...|
Mouse  1696 GPSALWEITWER-IDCFLPHLRDELFKQTVIQDPMPAEP--HSQKPLASTH 1743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	398/1867 (21%)
		DCB	30..212	CDD:292830	42/202 (21%)
		Sec7_N	312..465	CDD:289549	40/168 (24%)
		Sec7	582..767	CDD:279680	71/189 (38%)
		DUF1981	1080..1161	CDD:286414	18/147 (12%)
Gbf1	XP_006526643.1	Sec7_N	401..546	CDD:372313	38/157 (24%)
		COG5307	484..>1003	CDD:227623	147/569 (26%)
		Sec7	700..885	CDD:366596	71/189 (38%)
		PHA03247	<1730..1860	CDD:223021	4/16 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750