Protein Alignment Sec71 and Gbf1

DIOPT Version :10

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: XP_006526643.1
• Gene: Gbf1 / 107338
• MGIID: 1861607
• Length: 1862
• Species: Mus musculus
• Alignment Length: 1871
• Identity: 399/1871 - (21%)
• Similarity: 676/1871 - (36%)
• Gaps: 593/1871 - (31%)

  Fly     9 KEMFIVRALEKILA---DKDIRRSHHSQLKKSCDSAL---EQIKAELISAGQIAEGNELPCAALP 67
            |.::|::....|:.   .::.|.|.|..|.:..|..|   ..:|..|.|..:::|
Mouse     4 KNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFSNLKEVLNSVTELSE---------- 58

  Fly    68 LPKNDAASIINAETYFLPFELACKSRSPRIVVT--ALDCLQKLIAYGHLTGSIQDSANPGHLLID 130
                     |....:..||....:|......:|  ||..:.|.::|..:..:.:.:|.....:.|
Mouse    59 ---------IEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMAD 114

  Fly   131 RIVVTIYGCFSG--PQTDEAVQLQIIKALLTV--------VTSQHV-EIHEFTLLQAVRTCYDIY 184
            .:.   :..|.|  |.:||.|.::|::.|.|:        :|::.| ||    :....|.|:::.
Mouse   115 AVT---HARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI----MQSCFRICFEMR 172

  Fly   185 LSSKNLVNQTTARATLTQMLNVIFARM-----ENQVY---------------------------- 216
            ||.   :.:.:|..||..|:.::|.|:     |.:.|
Mouse   173 LSE---LLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNMKKLKMRAGGMSDSSKWKKQKRSP 234

  Fly   217 -------------ELPPPN-----SNPTNG--------SIHS----------EDCNGSG------ 239
                         |||.||     ||.|.|        ||.|          ..|..||
Mouse   235 RPPRHTTKVTPGSELPTPNGATLPSNLTGGVPFIDAPTSISSASSEAASTVVSPCTDSGLELSSQ 299

  Fly   240 ---EESLRD----------------SDEVIASELLAEIISAAYNEAMKDQESVGEPEPTLNGNDY 285
               :|.|.|                |.|:.||:.|......|:.|..:.......||..   .:.
Mouse   300 TTSKEDLTDLEQAGSPREITTSEPGSSEMGASDQLDPQQEGAHVEKAQSASVESIPEVL---EEC 361

  Fly   286 SSHSDH-DSVELHSENDAVVT--AKFTHILQKDAFL-----------VFRALCKLSMKPLPDGHP 336
            :|.:|| ||..:| :.|.|..  .:||...||:...           :||.|..|:       :|
Mouse   362 TSPADHSDSASVH-DMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLT-------NP 418

  Fly   337 DPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLC----VALSNNGVSLVPEVFELS 397
            ..:.:......:.||||.:.|::| ||.:. :..:..||..:|    ..||...::|    :..|
Mouse   419 HDRHNSEVMIHMGLHLLTVALESA-PVAQC-QTLLGLIKDEMCRHLFQLLSVERLNL----YAAS 477

  Fly   398 LSIFVALLSNFKVHLKRQIEVFFKEIF-LNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVN 461
            |.:...|..:.:.|||.|:|::.|::. :..:|.....:|.|.|.::|:.::......|.::|:|
Mouse   478 LRVCFLLFESMREHLKFQLEMYIKKLMEIITVENPKMPYEMKEMALEAVVQLWRIPSFVTELYIN 542

  Fly   462 YDCDFSAANLFERLVNDLSKIAQGRQALELGANPM--QEKSMRIRGLE------------CLVSI 512
            ||||:..:||||.|...|||          .|.|:  |..:..:..|:            |...:
Mouse   543 YDCDYYCSNLFEDLTKLLSK----------NAFPVSGQLYTTHLLSLDALLTVIDSTESHCQAKV 597

  Fly   513 LKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTT----------IQTMH--SGSSHSLNSN 565
            |..:.:..|.....|....    |.....|.:.:..|:          .:.:|  ||...|....
Mouse   598 LNTLNQQEKKETARPGFEA----VDGNPETNKSERATSDGKSTGVALDARGLHFPSGGWLSTEHG 658

  Fly   566 QEQLQDLPEA-------------------------LEERKMRKEVMETGIELFNRKPQKGVQFLQ 605
            :...:||.||                         |.|.|.:|:::.||.|.||:||:||:||||
Mouse   659 KPGCRDLEEAGDSGADKKFTRKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQ 723

  Fly   606 EKQLLGATCG--DIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFL 668
            ||.||.....  ::|:||.|:.||||.:||.::  :|..:.:::.:::..|.|:.:.:..|||..
Mouse   724 EKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFV--SDRKNMDLLESFVSTFSFQGLRLDEALRLY 786

  Fly   669 LEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHK--- 730
            ||.|||||||..|.||:|.|...:..||  ...|.::|..:.||:::|||.||.|:..|:.:
Mouse   787 LEAFRLPGEAPVIHRLLEVFTEHWRSCN--GSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAP 849

  Fly   731 MTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKM-KNNSGMLQQAKPTGKQAFITEKRRK 794
            ||.|::.|..:|::..| |..::.|..:|..|...||.| :..:|::               |..
Mouse   850 MTLEEFRKNLKGVNGGK-DFEQDILEDMYHAIKNEEIVMPEEQTGLV---------------REN 898

  Fly   795 LLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIA 859
            .:|::           |:...:..:..|.......:...:|.|.|.|.:||.|.......:..|.
Mouse   899 YVWSV-----------LLHRGASPEGVFLRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETII 952

  Fly   860 TLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNIDTI-----------K 913
            ...:.|.|....|:..:.:|...|..:.:|.:||.|::.|      .:|:.::           |
Mouse   953 QKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSES------IENLPSVFGSNPKAHIAAK 1011

  Fly   914 TLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQTTLKDSLNPSVK------- 971
            |:..:||..|:.|...|.:|::.:.||         .|.|.|..|...::|.::|:.|
Mouse  1012 TVFHLAHRHGDILREGWKNIMEAMLQL---------FRAQLLPKAMVEVEDFVDPNGKISLQREE 1067

  Fly   972 --EHIGETSSQSVV-------------------------VAVD--------RIFTGSMRLDGDAI 1001
              .:.||::..|.|                         ||:|        ::.|.|..|..:::
Mouse  1068 TPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESL 1132

  Fly  1002 VDFVKALCQVSVD-ELQQQQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEE 1065
            .:.:|||..|:.| |...::...|.|:.::.|...|.:|:    ..:||.:.:|...: |...::
Mouse  1133 QELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRV----GCVWQTVRDHLYHL-CVQAQD 1192

  Fly  1066 ISFF---ALDSLRQLSMKFMEKGEFS-----NFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQ 1122
            ..|.   |:..|.:|:::.:.:.|.|     :.|...        :||.:....:...|...:.:
Mouse  1193 FCFLVERAVVGLLRLAIRLLRREEISGQVLLSLRILL--------LMKPSVLSRVSHQVAYGLHE 1249

  Fly  1123 MVNSQAHNIRSG--WKNIFSIFHL-----------------------AAGDNEEP---------- 1152
            ::.:.|.||.||  |..:|::...                       |..|:|.|
Mouse  1250 LLKTNAANIHSGDDWATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLD 1314

  Fly  1153 ---------------------------IVELAFQTTGKIIGDLYK--------------RQFAIM 1176
                                       :|...:...||...|..|              .|:::.
Mouse  1315 RGYTSDSEVYTDHGRPGKIHRSATDADMVNSGWLVVGKDDIDNSKPGAGLSRPGPSPLVNQYSLT 1379

  Fly  1177 V-------------------------------DSFQDAVKCLSEFATA----------------- 1193
            |                               |:|:..||.|..|..|
Mouse  1380 VGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQDKRSKSHK 1444

  Fly  1194 ------RFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASV-------------------- 1232
                  ||.....|...|.|......|...   ..|:..|.|..|
Mouse  1445 YDSKGNRFKKKPKEGSMLRRPRGSNQHATR---GGHSDEEEDEGVPASYHTVSLQVSQDLLDLMH 1506

  Fly  1233 -------------AEEDR---------------VWVRGWFPMLFSLSCVVNRCKLDVRTRALTVL 1269
                         |||.|               :|...|.|:|..::|:....:..||.:|||.|
Mouse  1507 TLHTRAASIYSSWAEEQRHLEGGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYL 1571

  Fly  1270 FEIVKTYG-ESFKPHWWKDLFN-VIFRIFDNMKLPEHVTEKS-EWMTTTCNHALYAIIDVFTQYF 1331
            ...:..:. :......|:..|| |:|.:.  .||.|:::... ..|..|...|...:..||.|:
Mouse  1572 QRALLVHDLQKLDALEWESCFNKVLFPLL--TKLLENISPADVGGMEETRMRASTLLSKVFLQH- 1633

  Fly  1332 DVLGHLLLEELFAQLHWCV----------QQSNEQLARSGTNCLEN--LVISNGFKFN------- 1377
              |..||....||.| |..          ..|::.|:.:....|:|  ||:.....|:
Mouse  1634 --LSPLLSLSTFAAL-WLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGG 1695

  Fly  1378 ------ESTWDKTCQCIL-----DIFNATLPQDLLSWRPKAHSSNNIPQEH 1417
                  |.||:: ..|.|     ::|..|:.||.:...|  ||...:...|
Mouse  1696 GPSALWEITWER-IDCFLPHLRDELFKQTVIQDPMPAEP--HSQKPLASTH 1743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	398/1867 (21%)
Gbf1	XP_006526643.1	PLN03076	<430..>1179	CDD:215560	203/818 (25%)
		Sec7	700..885	CDD:460178	71/189 (38%)
		PHA03247	<1730..1860	CDD:223021	4/16 (25%)