Protein Alignment Sec71 and ARFGEF2

DIOPT Version :10

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: NP_006411.2
• Gene: ARFGEF2 / 10564
• HGNCID: 15853
• Length: 1785
• Species: Homo sapiens
• Alignment Length: 1796
• Identity: 1070/1796 - (59%)
• Similarity: 1302/1796 - (72%)
• Gaps: 183/1796 - (10%)

  Fly     6 TKTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPK 70
            ::||.||:.||||||||||:::|..||||:::|..||::||||:       |...|..||.|
Human     4 SQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEI-------EKQRLGTAAPP--- 58

  Fly    71 NDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVT 135
              .|:.|.|:.|||||||||:|:|||:|.|:||||||||||||:||:..||..||..||||||.|
Human    59 --KANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVET 121

  Fly   136 IYGCFSGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATL 200
            |..||.||||||.|||||||||||.|||.|:||||.|:||.|||||:|||:||||:|||||:|||
Human   122 ICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATL 186

  Fly   201 TQMLNVIFARMENQVY----ELPPP---------------------------NSNPT-------- 226
            ||||||||.||||||.    ||..|                           .|.||
Human   187 TQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLT 251

  Fly   227 --------NGSIHSEDCN-----GSGEESLRDSDEVIASELLAEIISAAYNEAMKDQESVGEPEP 278
                    :|.:.:|:.:     ||......|..:.:..::|.:::::|..|| .::..:.|||.
Human   252 NGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEA-AEKHGLTEPER 315

  Fly   279 TL--------------------NG--NDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFLVFR 321
            .|                    ||  :|..|.|..|::|..::... |.|:|:|:||||||||||
Human   316 VLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGHQ-VAARFSHVLQKDAFLVFR 379

  Fly   322 ALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVALSNNG 386
            :|||||||||.:|.||||||||||||:||.|||.:|||||||||::||||.|||||||||||.||
Human   380 SLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNG 444

  Fly   387 VSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFEHKWMVIQALTRICAD 451
            ||.||:||||||:||:.||||||:|||.|||||||||||||||.::|||||:|||||.|||||||
Human   445 VSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICAD 509

  Fly   452 AQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSILKCM 516
            ||.|||||||||||.:|||:|||||||||||||||...|||..|:||.|:|.:||||||||||||
Human   510 AQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCM 574

  Fly   517 VEWSKDLYVNPNMPVPPMQVQSPTSTEQDQAD---------TTIQTMHSGSSHSLNSNQEQLQDL 572
            ||||||||||||...   .:.....|:|:..|         .::.:|.|..|   :..|..:||.
Human   575 VEWSKDLYVNPNHQT---SLGQERLTDQEIGDGKGLDMARRCSVTSMESTVS---SGTQTTVQDD 633

  Fly   573 PEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIG 637
            ||..|..|.:||::|.||||||:||::|:|||||:.:||.:..|||::||::||||.|.:|:::|
Human   634 PEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLG 698

  Fly   638 ENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLF 702
            ::...:||||.||:|..||.:.|.|:|||..|||||||||||||||||||||:||.|||....||
Human   699 DSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLF 763

  Fly   703 QSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEI 767
            .||||.||||:|||||||||||||||:||||||||||||||:||| |||||||||||:||...:|
Human   764 ASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSK-DLPEEYLSSIYEEIEGKKI 827

  Fly   768 KMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVR 832
            .||....:....|.| ||...:||:|:||:|:|||.::.||..||::|||.|:|||||.||:|||
Human   828 AMKETKELTIATKST-KQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVR 891

  Fly   833 PMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNA 897
            ||||:.|||.|||:|:|||:|||.|:|:|||:||||||||||||.|.|||||||||||||:||.|
Human   892 PMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTA 956

  Fly   898 NSPINEMKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQTTL 962
            :|.|.|||.||||||||||.||||||||||:||.:|:||||||||||||||||:.::|||:....
Human   957 SSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRER 1021

  Fly   963 KDSLN---------------------------PSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDA 1000
            :.||.                           .|.:|.:|||||||||||||||||||.||||:|
Human  1022 EGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNA 1086

  Fly  1001 IVDFVKALCQVSVDEL-QQQQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNE 1064
            |||||:.||.||:||| ....|||||||||||||||||.||||||||||.|:|:|||.||||.||
Human  1087 IVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNE 1151

  Fly  1065 EISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAH 1129
            :::.||:||||||||||:||||.:|||||||||||||||||||.||.||||.:|||||||||||.
Human  1152 DVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAA 1216

  Fly  1130 NIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFA-TA 1193
            ||||||||||::||.||.|::..|||||||||..|:..:::..|...:|||||||||||||| .|
Human  1217 NIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNA 1281

  Fly  1194 RFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPMLFSLSCVVNRCK 1258
            .|||||||||||:|.|.:.|.|.|::..|:.  .:|.:||..||||||||||:||.|||::||||
Human  1282 AFPDTSMEAIRLIRFCGKYVSERPRVLQEYT--SDDMNVAPGDRVWVRGWFPILFELSCIINRCK 1344

  Fly  1259 LDVRTRALTVLFEIVKTYGESFKPHWWKDLFNVIFRIFDNMKLPEHVTEKSEWMTTTCNHALYAI 1323
            ||||||.|||:|||:|:||.:|:.|||:|||.::|||||||||||.::|||||||||||||||||
Human  1345 LDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAI 1409

  Fly  1324 IDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCI 1388
            .|||||:::.|..:||.::||||.|||:|.||||||||||||||||||||.||:...||:||.|:
Human  1410 CDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCM 1474

  Fly  1389 LDIFNATLPQDLLSWRP--------KAH-----------SSNNIPQEHNH--------------- 1419
            ||||..|:|..||:|||        :.|           |.:..|.|...
Human  1475 LDIFKTTIPHVLLTWRPVGMEEDSSEKHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRP 1539

  Fly  1420 ------FEALHIRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQLLECQR 1478
                  |.:|.|:||||||||||:|||||:||||:|||||.:..|..|.....       :..:.
Human  1540 YANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDAD-------IHIET 1597

  Fly  1479 EEQGMYGYLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETSSLACV 1543
            |:||||.|:.::.|..|.|||.:||.|:|.||::::||::||||||||..||||||||||||||.
Human  1598 EDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACC 1662

  Fly  1544 LRIFFKMYGDENRRSDWPGIEQELVQVCKEALGYYLSLQSEAHRDAWTSLLLLILTRLLKMSDAR 1608
            |||.|:||.|||||..|..|:|.|:.||.|||.|::::.||:||:||||||||:||:.||::|.:
Human  1663 LRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEK 1727

  Fly  1609 FATHVSNYYSLLCEMMCFDLKPELRSVLRRVFMRIGPVFNI 1649
            |..|.|.||..|||:|.|||.||||:|||:.|:|||.|:.|
Human  1728 FKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKI 1768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	1024/1718 (60%)
ARFGEF2	NP_006411.2	DCB, DCB:DCB domain and DCB:HUS domain interaction	2..224		142/231 (61%)
		PLN03076	11..1711	CDD:215560	1030/1730 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..285		8/52 (15%)
		HUS, DCB:HUS domain interaction	508..528		16/19 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1535		3/20 (15%)