DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and arfgef1

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_012820711.2	Gene:	arfgef1 / 100492065	XenbaseID:	XB-GENE-6050637	Length:	1859	Species:	Xenopus tropicalis

Alignment Length:	1843	Identity:	1104/1843 - (59%)
Similarity:	1319/1843 - (71%)	Gaps:	224/1843 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPKNDAAS 75
            ||:.|||:|||:||:::|:|||||:|:|:.|||:||.|........:.::...:.|| |....|:
Frog     1 MFLTRALDKILSDKEVKRAHHSQLRKACEVALEEIKCETEKQSSPQDESKSGSSTLP-PVKSKAT 64

  Fly    76 IINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGCF 140
            .|.|:.|||||||||:|:.||||.|:|||||||||||||||:..||..||..|||||:.||.|||
Frog    65 FIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCF 129

  Fly   141 SGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLN 205
            .||||||.|||||||||||.|||||:||||.|:||||||||:|||:||||||||||:||||||||
Frog   130 QGPQTDEDVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLASKNLVNQTTAKATLTQMLN 194

  Fly   206 VIFARMENQV---------------------------YELPP----------------------- 220
            |||||||||.                           .||||
Frog   195 VIFARMENQALQEAKHMEKERHKQQHHLQHSPVSHHELELPPMRHHLEQTDQLTREHEGAIDQHL 259

  Fly   221 --------PNSNPTNG-----------------SIHSE-----------DCNGSGEESLRDSDEV 249
                    ..:.|.||                 ..||:           ||    |||.::..:.
Frog   260 NYMENSLQEEAEPENGYDAPSAENELPETNQCAENHSKADLEIGDETSIDC----EESTQEVIQS 320

  Fly   250 IASELLAEII----------SAAYNEAMKDQESV------GEP-----EPTLNGNDYSSHSDHDS 293
            |..|:|..::          :|..:|...|.:|:      |.|     .|:|..:..|..|:...
Frog   321 IIQEMLNSVVGEEETVRAECTARISEDPSDGDSIHANGIPGTPISMAYTPSLPDDRLSVSSNDTQ 385

  Fly   294 VELHSENDAVVT--AKFTHILQKDAFLVFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLI 356
            ....|.|.:..|  |||:||||||||||||:|||||||||.||.|||||||||||||||.|||.|
Frog   386 ARKESGNTSAPTPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKVLSLQLLLSI 450

  Fly   357 LQNAGPVFRSNEMFIMAIKQYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFK 421
            ||||||||::|||||.|||||||||||.||||.||||||||||||:.||||||:|||.|||||||
Frog   451 LQNAGPVFKTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKLHLKMQIEVFFK 515

  Fly   422 EIFLNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGR 486
            ||||.|||.::|||:|||||||.|||||||||||||||||||||.:|||:|||||||||||||||
Frog   516 EIFLYILETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGR 580

  Fly   487 QALELGANPMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADT-- 549
            .:.|||.:.:||.|:|.:||||||||||||||||||||||||......| :.|  :|||..||
Frog   581 GSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDLYVNPNSQTTLGQ-EKP--SEQDTHDTKH 642

  Fly   550 --------TIQTMHSGSSHSLNSNQEQLQ--DLPEALEERKMRKEVMETGIELFNRKPQKGVQFL 604
                    ::.::.|.:|..:.|...|:.  |.||..|..|.:||::|.||:|||:||::|:|:|
Frog   643 PETINRYGSLNSLDSTASSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL 707

  Fly   605 QEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLL 669
            ||:.:||.:..|||::||::||||.|.:|.::|:||..:||||.||:|..||:..:.|:|||..|
Frog   708 QEQGMLGTSPDDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFQGKDFVSALRMFL 772

  Fly   670 EGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKE 734
            ||||||||||||||||||||:||.|||....||.||||.||||:|||||||||||||||.|||||
Frog   773 EGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKSKMTKE 837

  Fly   735 QYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKPTGKQAFITEKRRKLLWNM 799
            |||||||||:||| ||||||||:||:||:..:|.||....:....| :.|.:..:||:|:||:|:
Frog   838 QYIKMNRGINDSK-DLPEEYLSAIYNEIAGKKISMKETKELAITTK-SSKPSVASEKQRRLLYNL 900

  Fly   800 EMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLD 864
            |||.::.||..||::||||::|||||.||||||||||:||||||||||||||||||.|:|:|||:
Frog   901 EMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLE 965

  Fly   865 GIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNIDTIKTLIMVAHTDGNYLGSS 929
            ||||||||||||.:.||||||||||||||||..:|.|.|||.||||||||||.||||||||||||
Frog   966 GIRCAIRIACIFCIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGSS 1030

  Fly   930 WLDIVKCISQLELAQLIGTGVRPQFLS-------GAQTTLKDSLN------------------PS 969
            |.:|:||||||||||||||||:|:::|       |:.|..||..:                  .|
Frog  1031 WHEILKCISQLELAQLIGTGVKPRYISGTVRNREGSFTGTKDQASDEFVSLGLVGGNVDWKQMAS 1095

  Fly   970 VKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDE-LQQQQPRMFSLQKIVEIS 1033
            ::|.||||||||||||||||||||.||||:|:||||:.||.||:|| |....|||||||||||||
Frog  1096 IQESIGETSSQSVVVAVDRIFTGSTRLDGNAVVDFVRWLCAVSMDELLSPMHPRMFSLQKIVEIS 1160

  Fly  1034 YYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLR 1098
            ||||.||||||||||:|:|:|||.||||.||:::.||:||||||||||:||||.:||||||||||
Frog  1161 YYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLR 1225

  Fly  1099 PFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGK 1163
            |||||||:|.||.|||||||||||||||||.|||||||||||:|||||.|.:|.||||||||||.
Frog  1226 PFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGH 1290

  Fly  1164 IIGDLYKRQFAIMVDSFQDAVKCLSEFA-TARFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGME 1227
            |:..::::.|...:|||||||||||||| .|.|||||||||||:|.||:.|.:.||.|.|:.  .
Frog  1291 IVTLVFEKHFPATIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYT--S 1353

  Fly  1228 NDASVAEEDRVWVRGWFPMLFSLSCVVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKDLFNVI 1292
            :|.:||.|||||||||||:||.|||::||||||||||.|||:||::||||.:|:.|||:|||.::
Frog  1354 DDMNVAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEVMKTYGHTFEKHWWQDLFRIV 1418

  Fly  1293 FRIFDNMKLPEHVTEKSEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQL 1357
            |||||||||||..|||:||||||||||||||.|||||||:||..:||:::||||:|||||.||||
Frog  1419 FRIFDNMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYFEVLSDVLLDDIFAQLYWCVQQDNEQL 1483

  Fly  1358 ARSGTNCLENLVISNGFKFNESTWDKTCQCILDIFNATLPQDLLSWRP----------------- 1405
            ||||||||||:||.||.||....|||||.|:||||..|:|..||:|:|
Frog  1484 ARSGTNCLENVVILNGEKFTLEIWDKTCNCMLDIFKTTIPHALLTWKPAGGDTELSSQADGRDKQ 1548

  Fly  1406 ------------------KAHSSNNI-------PQEHNH-------------FEALHIRCVVQLE 1432
                              .|.|..||       .||..|             |.||.|:||||||
Frog  1549 ADSVSQKSVDIHESIQPRTADSRRNIQTQVSLVAQEEGHLARPGARVAEQRLFAALLIKCVVQLE 1613

  Fly  1433 LIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQL-LECQREEQGMYGYLRTRQLLTLA 1496
            ||||:||||||||||||||||.||.|..|..        .| :....::||||.:|.::||..|.
Frog  1614 LIQTIDNIVFFPATSRKEDAENLAAAQRDTV--------HLDVHVDTQDQGMYRFLTSQQLFKLL 1670

  Fly  1497 DCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETSSLACVLRIFFKMYGDENRRSDWP 1561
            |||::||||||.||::::||:.||:|||||..||||||||||||||.|||.|:||.|::|...|.
Frog  1671 DCLLESHRFAKAFNSNNEQRTSLWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDDSRSDAWD 1735

  Fly  1562 GIEQELVQVCKEALGYYLSLQSEAHRDAWTSLLLLILTRLLKMSDARFATHVSNYYSLLCEMMCF 1626
            .::..|:.||.|||.|:|:|.||:||:|||:||||.||::||:||.||..|.|.||.||||::.|
Frog  1736 EVQHRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDERFKAHASFYYPLLCEIIQF 1800

  Fly  1627 DLKPELRSVLRRVFMRIGPVFNI 1649
            ||.||||::|||.|.|||.||.|
Frog  1801 DLIPELRAILRRFFHRIGLVFKI 1823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	1056/1770 (60%)
		DCB	30..212	CDD:292830	124/181 (69%)
		Sec7_N	312..465	CDD:289549	132/152 (87%)
		Sec7	582..767	CDD:279680	124/184 (67%)
		DUF1981	1080..1161	CDD:286414	68/80 (85%)
arfgef1	XP_012820711.2	PLN03076	6..1753	CDD:215560	1055/1766 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	609	1.000	Domainoid score	I189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4687
Inparanoid	1	1.050	2085	1.000	Inparanoid score	I45
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D50759at33208
OrthoFinder	1	1.000	-	-		FOG0001583
OrthoInspector	1	1.000	-	-		otm48499
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X714
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060