DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and arfgef2

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_002933226.3	Gene:	arfgef2 / 100492055	XenbaseID:	XB-GENE-6041969	Length:	1792	Species:	Xenopus tropicalis

Alignment Length:	1801	Identity:	1079/1801 - (59%)
Similarity:	1285/1801 - (71%)	Gaps:	191/1801 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPKN 71
            |||.||:.|||||||||||::::|:|||:|:|..|||:||.||:|.   .||...|
Frog     9 KTKSMFLSRALEKILADKDVKKAHNSQLRKACQVALEEIKVELVSQ---KEGTATP--------- 61

  Fly    72 DAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTI 136
            ..|..|.|:.|||||||||:.:|||:|.|:||||||||||||:||:..|...||..||||||.||
Frog    62 SKAKFIEADKYFLPFELACQLKSPRVVSTSLDCLQKLIAYGHITGNAPDKGAPGKRLIDRIVDTI 126

  Fly   137 YGCFSGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLT 201
            ..||.||||||.|||||||||||:||...|||||.|:|..|||||:|||:||||||||||:||||
Frog   127 CSCFQGPQTDEGVQLQIIKALLTIVTCPFVEIHEGTILHTVRTCYNIYLASKNLVNQTTAKATLT 191

  Fly   202 QMLNVIFARMENQ-------------------------------------VYELP-PPNSNPTN- 227
            |||||||.|||||                                     :.||| |.|.|.||
Frog   192 QMLNVIFIRMENQALQEQQEYVIQHQKIHSPVPYRAMGSPNLKHKNNNHLLNELPVPGNDNSTNP 256

  Fly   228 --------GSIHSE---DCNGSGE-ESLRDSDEVIAS-ELLAEIISAAYNEAMKDQE-------- 271
                    |:.|:|   .||.:.: ||:   .|:.|: |..|:||....:...|:||
Frog   257 EQGMEAAEGNEHTEGADSCNVTTDVESV---SEISANEETPADIIEDTTDSVCKEQEEREAVDEA 318

  Fly   272 -----SVGEPEPTLN-------------GNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFL 318
                 ..|:..||||             |...||..:.:|..||.:|..   |||:|||||||||
Frog   319 ATSEAESGDLPPTLNLPESIQTNGISDDGQSISSTDNLESDSLHGQNSG---AKFSHILQKDAFL 380

  Fly   319 VFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVALS 383
            |||:|||||||||.:|.|||||||||||::||.|||.:|||||||||::||||.|||||||||||
Frog   381 VFRSLCKLSMKPLGEGPPDPKSHELRSKIISLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALS 445

  Fly   384 NNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFEHKWMVIQALTRI 448
            .||||.||:||||||:||:||||:||:|||.|:|||||||||||||.:||||||||||||.||||
Frog   446 KNGVSSVPDVFELSLAIFLALLSHFKMHLKMQVEVFFKEIFLNILETSSSSFEHKWMVIQTLTRI 510

  Fly   449 CADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSIL 513
            |||||.|||||||||||.:|||:|||||||||||||||...|||..|.||..:|.:|||||||||
Frog   511 CADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPTQELCLRKKGLECLVSIL 575

  Fly   514 KCMVEWSKDLYVNPNMPVPPMQVQS--PTSTEQDQADTT---------IQTMHSGSSHSLNSNQE 567
            |||||||||||||||......|.::  |.|.|....:||         ..|:.||...:  |.|.
Frog   576 KCMVEWSKDLYVNPNFQSNLGQEKNSDPESCENKTPETTGRRYSVSSKDSTVSSGIGST--STQT 638

  Fly   568 QLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVI 632
            .:.|.||..|..|.:||::|.||||||:||::|:|:|||:.:||....|||::||:::|||.|.|
Frog   639 SIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGMQYLQEQGMLGTMPQDIAQFLHQEDRLDFTQI 703

  Fly   633 GNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNP 697
            |.::|||:..::|||.||:|..||...:.|:|||..|||||||||||||||||||||:||.|||.
Frog   704 GEFLGENNRFNREVMYAYVDQLDFCDKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQ 768

  Fly   698 KNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEI 762
            ...||.||||.||||:|||||||||||||||:||||||||||||||:||| ||||||||||||||
Frog   769 GQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSK-DLPEEYLSSIYDEI 832

  Fly   763 SEHEIKMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKH 827
            ...:|.||.........|.| |.:..:||:|:||:|||||.::.||..||::|||.|:.||||.|
Frog   833 EGKKIAMKETKEHTIATKST-KPSVASEKQRRLLYNMEMEQMAKTAKALMEAVSHAKAQFTSATH 896

  Fly   828 LEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARF 892
            |:|||||||:.|||.|||||:|||||||.|:|.|||:|||||:||:|||.|.|||||||||||||
Frog   897 LDHVRPMFKLVWTPLLAAFSIGLQDCDDSEVANLCLEGIRCAVRISCIFTMQLERDAYVQALARF 961

  Fly   893 TLLNANSPINEMKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSG 957
            :||.|:|.|.|||.||||||||||.|||||||||.|||.:|:||||||||||||||||:.:::||
Frog   962 SLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLASSWHEILKCISQLELAQLIGTGVKTRYISG 1026

  Fly   958 AQTTLKDSLN-------------------------PSVKEHIGETSSQSVVVAVDRIFTGSMRLD 997
            .....:.|:.                         .|.:|.:|||||||||||||||||||.|||
Frog  1027 TGREREGSIKSYTSGGEEFMSLGNLVGVGVDKKQMTSFQESVGETSSQSVVVAVDRIFTGSTRLD 1091

  Fly   998 GDAIVDFVKALCQVSVDELQQ-QQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCN 1061
            |.||||||:.||.||:|||.. ..|||||||||||||||||.||||||||||||:|:|||.||||
Frog  1092 GYAIVDFVRCLCAVSMDELASVHHPRMFSLQKIVEISYYNMNRIRLQWSRIWQVIGDHFNKVGCN 1156

  Fly  1062 SNEEISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNS 1126
            .||:::.||:||||||||||:||.|.:|||||||||||||||||||.||.|||||:|||.|||||
Frog  1157 PNEDVAIFAVDSLRQLSMKFLEKDELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCITQMVNS 1221

  Fly  1127 QAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFA 1191
            ||.||||||||:|::|:.||.|:...||||:|.|.|..:.:::::.|...:||||||:|||||||
Frog  1222 QAGNIRSGWKNVFAVFYQAASDHNGNIVELSFHTVGHTVTNVFQQHFPSAIDSFQDAIKCLSEFA 1286

  Fly  1192 -TARFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPMLFSLSCVVN 1255
             .|.|||||||||||:|.||:.|.|.||...|:.  .:|.:||..||||||||||:||.|||::|
Frog  1287 CNAAFPDTSMEAIRLIRYCAKYVSEKPQALREYT--SDDMNVAPGDRVWVRGWFPILFELSCIIN 1349

  Fly  1256 RCKLDVRTRALTVLFEIVKTYGESFKPHWWKDLFNVIFRIFDNMKLPEHVTEKSEWMTTTCNHAL 1320
            |||||||||.|||:|||:|:||.:|:.|||.|||.::|||||||||||..:||||||||||||||
Frog  1350 RCKLDVRTRGLTVMFEIMKSYGHTFENHWWHDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHAL 1414

  Fly  1321 YAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTC 1385
            |||.|||||:::.|..:||.::.:||||||:|.|||||||||||||||||.||.||:...|||||
Frog  1415 YAICDVFTQFYEALNSVLLSDILSQLHWCVKQDNEQLARSGTNCLENLVILNGEKFSPEVWDKTC 1479

  Fly  1386 QCILDIFNATLPQDLLSWRP-----------------------------KAHS--SNNIPQ---- 1415
            .|:||||.:|:|..||:|||                             :|||  ||....
Frog  1480 TCMLDIFKSTIPSVLLTWRPTAMEEDSDKRYDLEIDRQSMSSMDRNTSDRAHSQISNTTEDTWKG 1544

  Fly  1416 -------EHNHFEALHIRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQL 1473
                   :...|..|.|:||||||||||:|||||:||||:|||||.||.|..|...
Frog  1545 KSSERLADQKLFAGLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHLAAAQRDTLD--------- 1600

  Fly  1474 LECQREEQGMYGYLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETS 1538
            :....|:||||.|:.|:.|..|.|||.:||.|||.||::::||:.||||||||..||||||||||
Frog  1601 IHIDSEDQGMYKYMCTQHLFKLLDCLQESHSFAKAFNSNNEQRTALWRAGFKGKSKPNLLKQETS 1665

  Fly  1539 SLACVLRIFFKMYGDENRRSDWPGIEQELVQVCKEALGYYLSLQSEAHRDAWTSLLLLILTRLLK 1603
            ||||.|||.|:||.||.||..|..||..|:.||.|||.|::::.||:||:|||:||||:||:.||
Frog  1666 SLACCLRILFRMYTDEKRRDSWGDIESRLLNVCSEALAYFITVNSESHREAWTNLLLLLLTKTLK 1730

  Fly  1604 MSDARFATHVSNYYSLLCEMMCFDLKPELRSVLRRVFMRIGPVFNI 1649
            :||.:|..|.|.||..|||:|.|||.||||||||:.|:|||.||:|
Frog  1731 VSDEKFKAHASRYYPHLCEIMQFDLIPELRSVLRKFFLRIGVVFSI 1776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	1030/1724 (60%)
		DCB	30..212	CDD:292830	117/181 (65%)
		Sec7_N	312..465	CDD:289549	127/152 (84%)
		Sec7	582..767	CDD:279680	126/184 (68%)
		DUF1981	1080..1161	CDD:286414	59/80 (74%)
arfgef2	XP_002933226.3	PLN03076	6..1706	CDD:215560	1035/1729 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	609	1.000	Domainoid score	I189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2085	1.000	Inparanoid score	I45
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D50759at33208
OrthoFinder	1	1.000	-	-		FOG0001583
OrthoInspector	1	1.000	-	-		otm48499
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X714
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060