Protein Alignment Sec71 and mon2

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: XP_031754733.1
• Gene: mon2 / 100489029
• XenbaseID: XB-GENE-975876
• Length: 1745
• Species: Xenopus tropicalis
• Alignment Length: 1767
• Identity: 327/1767 - (18%)
• Similarity: 590/1767 - (33%)
• Gaps: 567/1767 - (32%)

  Fly     1 MHNNSTKTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAA 65
            |.:.||.:....|.:.|:.:.:|   .|....:.||......|..::.::....||..:.....|
 Frog     1 MSSASTTSSPEAIKKLLDNMQSD---LRGLSMECKKKFPPVKEAAESGIVKVKNIAARSPDILTA 62

  Fly    66 LPLPKNDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLT-GSIQDSANPGHLLI 129
            |   |.:::.::.      ||.:.|.::.|:|....|..:|:|:::..:: |:..:..|....|:
 Frog    63 L---KENSSEVVQ------PFLMGCGTKEPKITQLCLAAIQRLMSHEVVSEGAAGNIINMLWQLM 118

  Fly   130 DRIVVTIYGCFSGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQT 194
            :          :|.:     :|::::.:|.::|:..| :|:.:|.:|:..|:.::.:..|:.|.|
 Frog   119 E----------NGLE-----ELKLLQTVLVLLTTNTV-VHDESLSKAIVLCFRLHFTKDNITNNT 167

  Fly   195 TARATLTQMLNVIFARMENQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDSDEVIASELLAEII 259
            .| ||:.|::.|:|.||
 Frog   168 AA-ATVRQVVTVVFERM------------------------------------------------ 183

  Fly   260 SAAYNEAMKDQESVGEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFLVFRALC 324
             .|.:|..||  :|.:|.|.: ||              |...:|.|.|   ...|||:::|:.||
 Frog   184 -VAEDERHKD--AVEQPVPVI-GN--------------SNRRSVSTLK---PCAKDAYMLFQDLC 227

  Fly   325 KLSMKPLP---DGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVAL---- 382
            :|.....|   .|..:      .::...|.||..:|.:...||..::.|...:|:.:|..:
 Frog   228 QLVNADAPYWLVGMTE------MTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLF 286

  Fly   383 ---------SNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFK------EIFLNILEANS 432
                     ||:..|..| |.:....|.:.||....|.:|:    |:.      ||||::|....
 Frog   287 SPNIKFRQGSNSNASPAP-VEKPYFPICMRLLRVVSVLIKQ----FYSLLVTECEIFLSLLVKFL 346

  Fly   433 SSFEHKWM---VIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGAN 494
            .:.:.:|:   .::::.|:|...|.:.....:||....:..:|..:||.|....|
 Frog   347 DADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQ---------- 401

  Fly   495 PMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTTIQTMHSGSS 559
                                       .|::.|:        ..|.||          |.:..::
 Frog   402 ---------------------------SLFLIPS--------AGPAST----------TTNPPAA 421

  Fly   560 HSLNSNQEQLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHED 624
            |.||.....|         .:|.|.|::.|                     |:|....|.
 Frog   422 HLLNGGIVLL---------LQMEKAVVQAG---------------------GSTSITPAS----- 451

  Fly   625 ERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFA 689
               ::|..|.....::       ...:.||::|             |..:|
 Frog   452 ---NQTTSGMAAATSN-------TTVLPAFEYR-------------GTWIP-------------- 479

  Fly   690 SRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEY 754
                                :|..||             ....|..|::|...:  ....:||.|
 Frog   480 --------------------ILTISI-------------QGSAKATYLEMLDKV--EPPTIPEGY 509

  Fly   755 LSS----------------IYDEISEHEIKMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEV 803
            ..|                |..||.:.|.....::...:...||..|             .::.|
 Frog   510 AMSVAFHCLLDLVRGITTMIEGEIGQAETDSHISAEETRPNAPTSDQ-------------QDLPV 561

  Fly   804 ISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRC 868
            :|..:.         |.|...:...|    |....|...|||.|: |.|....|.||..:  ::.
 Frog   562 VSDPSD---------KDPGCRSVWEE----MINACWCGLLAALSL-LLDASTDETATENI--LKA 610

  Fly   869 AIRIACI---FHMSLERDAYVQALAR--------FTLLNAN-------------------SPINE 903
            .:.:|.:   ..:...|||.:.|:.:        .|:||.:                   ||.::
 Frog   611 EMTMAALCGKLGLVTPRDALITAICKGSLPPHYALTVLNTSSAAICNKSYSIQGQNVQMISPSSD 675

  Fly   904 ---------------------MKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQL-- 945
                                 :.||||..::||:.:||..|.|||:||        ||.||.|
 Frog   676 SHQQVVAVGQPLAVQPQGTVMLTAKNIQCMRTLLNLAHCHGGYLGTSW--------QLVLATLQH 732

  Fly   946 ----------IGTGVRP-QFLSGAQTTLKDSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGD 999
                      .|..::| :.:.|..|.|..::         .|....:...:.|:|..|..||..
 Frog   733 LVWILGLKPSSGGALKPGRAVEGPSTVLTTAV---------MTDLPIISTILSRLFESSQYLDDV 788

  Fly  1000 AIVDFVKALCQVSVDEL-----QQQQPRMFSLQKIVEISYYNMERIRLQW----SRIWQVLGEHF 1055
            ::...:.|||.:|::.:     ..::|.:|::.|::|....||.||.:.|    ..:.:.:.:|.
 Frog   789 SLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLIEKVCQHP 853

  Fly  1056 NAVGCNSNEEISFFALDSLRQLSMKFMEKGEFS-NFRFQKDFLRPFEHIMKKNASPAIRDMVVRC 1119
            ||    ...|....||.||.:..:.|..:.:.| |.|.|...|.|.:. :.......||...:.|
 Frog   854 NA----RMREWGAEALTSLIKAGLAFKHEPQLSENQRLQLLLLNPLKE-LSNIIHHDIRLKQLEC 913

  Fly  1120 IAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAV 1184
            :.|::.||..::..||..:..:......|..|.::..|||....::.|...   .:.....|..|
 Frog   914 VLQILQSQGDSLGPGWPLVLGVIGAIRNDQGESLIRNAFQCLQLVVTDFLP---TMPCTCLQIVV 975

  Fly  1185 KCLSEFATARFP-DTSMEAIRLVRTCAQCVHEAPQLFAEHAGMEND--ASVAEEDRVWVRG---- 1242
            :....|...... :.|:.:|.|:...:...::..:...:....|.|  ...|:|..:.:..
 Frog   976 EVAGSFGLQNQELNISLTSIGLLWNISDYFYQRGESIEKELNREEDLLQKQAKEKGITLNRPFHP 1040

  Fly  1243 -------WFPMLFSLS--CVVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKD-LFNVIFRIFD 1297
                   |..:...|.  ||..|..  ||..|...||..:..:|...:...|.. ::.|:|::.:
 Frog  1041 APPFDCLWLCLYAKLGELCVDTRPA--VRKSAGQTLFSTIGAHGTLLQHATWHTVIWKVLFQLLN 1103

  Fly  1298 NMKLPEHVTEKSEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGT 1362
            .::         |..||.                                     ..|::...|.
 Frog  1104 QVR---------ESSTTA-------------------------------------DKEKIESGGG 1122

  Fly  1363 NCLENLVISNGFKFNESTWDKTCQCILDIFNAT--LPQDL----LSWRPKAHSSNNIPQEHNHFE 1421
            |.|.:.......|....||..|...:..|||..  |.|.|    .:|        ::..:|....
 Frog  1123 NILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSKAW--------DVLLDHIQSA 1179

  Fly  1422 ALHIRCVVQLELIQTMDNIVFFPATSRKED-AETLAQAAAD---LTGG-RSGSQSQLLECQREEQ 1481
            ||.....|.|..:::...|:...:.:|..| .|:|...:..   |.|. .||....|:......:
 Frog  1180 ALSKNNEVSLAALKSFQEILQIVSPTRDMDKPESLPGISVPVPVLIGPVASGLGRPLVRADSTGE 1244

  Fly  1482 GMYGYLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFK-------GSVKPNLLKQETS- 1538
            .:..|....|.:|:                |..:.:.||.|.:.       .|.||.:...:.:
 Frog  1245 RLSRYSIPEQPITV----------------DEIEDASLWWAAWNTWYRIGTESTKPPITCDKLTF 1293

  Fly  1539 -----SLACVLRIFFKMYGDENRRSDWPGIEQEL---------VQVCKEALGYYLSLQSEAHRDA 1589
                 .|..:::||..:|...........: |:|         |.:..:|..:.|...:||   .
 Frog  1294 IPSQPFLTALIQIFPALYQHIKTAFSMDDL-QKLGVILHGAVSVPISSDASPFILPSYTEA---V 1354

  Fly  1590 WTSLLLLILTRL 1601
            .|||...:||.|
 Frog  1355 LTSLQESVLTAL 1366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	315/1732 (18%)
		DCB	30..212	CDD:292830	38/182 (21%)
		Sec7_N	312..465	CDD:289549	40/177 (23%)
		Sec7	582..767	CDD:279680	26/200 (13%)
		DUF1981	1080..1161	CDD:286414	20/81 (25%)
mon2	XP_031754733.1	DCB	12..183	CDD:406594	41/199 (21%)
		Sec7_N	215..384	CDD:403860	40/179 (22%)
		DUF1981	<899..957	CDD:401312	13/57 (23%)
		Mon2_C	960..1735	CDD:374431	85/486 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000