Protein Alignment Sec71 and mon2

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: XP_021326251.1
• Gene: mon2 / 100334806
• ZFINID: ZDB-GENE-030131-2712
• Length: 1712
• Species: Danio rerio
• Alignment Length: 1696
• Identity: 310/1696 - (18%)
• Similarity: 540/1696 - (31%)
• Gaps: 642/1696 - (37%)

  Fly     5 STKTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLP 69
            ||.:.|. :.:.||.:.||   .||...:.||......|..::.::....||..|....|||
Zfish     6 STSSPEA-VKKLLENMQAD---LRSLSMECKKKFPPVKEAAESGIVKIKTIAARNTDILAAL--- 63

  Fly    70 KNDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVV 134
            |.:::.::.      ||.:.|.::.|:|....|..:|:|:::     .:...|..|:      ::
Zfish    64 KENSSEVVQ------PFLMGCGTKEPKITQLCLAAIQRLMSH-----EVVSEAAAGN------II 111

  Fly   135 TIYGCFSGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARAT 199
            .:.........:|...||.:..|||..|..|.|:    |.:|:..|:.::.:..|:.|.|.| ||
Zfish   112 NMLWQLMENGLEELKLLQTVLVLLTTNTIVHDEV----LSKAIVLCFRLHFTKDNITNNTAA-AT 171

  Fly   200 LTQMLNVIFARMENQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDSDEVIASELLAEIISAAYN 264
            :.|::.|:|.||                                                 .|.:
Zfish   172 VRQVVTVVFERM-------------------------------------------------VAED 187

  Fly   265 EAMKDQESVGEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFLVFRALCKLSMK 329
            |..|   .:.|..|.:.||              ....:|.|.:.:   .|||:::|:.||:|...
Zfish   188 ERFK---GLNEEPPAVQGN--------------CNRRSVSTLRPS---AKDAYMLFQDLCQLVNA 232

  Fly   330 PLP---DGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVAL--------- 382
            ..|   .|..:      .::...|.||..:|.:...||..::.|...:|:.:|..:
Zfish   233 DAPYWLVGMTE------MTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIK 291

  Fly   383 -----SNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFK------EIFLNILEANSSSFE 436
                 |::..|..| |.:....|.:.||....|.:|.    |:.      ||||::|.......:
Zfish   292 FRQGSSSSSASPAP-VEKPYFPICMRLLRVVSVLIKH----FYSLLVTECEIFLSLLVKFLDGEK 351

  Fly   437 HKWM---VIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQE 498
            .:|:   .::::.|:|.....:.....:||....:..:|..:||.|....|
Zfish   352 PQWLRAVAVESVHRLCVQPHLLRSFCQSYDMKPHSTKVFRDIVNALGSFIQ-------------- 402

  Fly   499 KSMRIRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTTIQTMH------SG 557
                                   .|::     :|.....|.|||....:.::.|...      :|
Zfish   403 -----------------------SLFI-----LPSAGNTSSTSTPAGGSVSSSQASGPGGPGLTG 439

  Fly   558 SSHSLNSNQEQLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLH 622
            :..:|.:.        .|.|.|       .|.|.|.|...|...:               |.:|
Zfish   440 AGGALTTQ--------AAFEYR-------GTWIPLMNVSVQGSAK---------------ATYL- 473

  Fly   623 EDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLP-GEAQKIDRLME 686
              |.|||                                       :|...:| |.|..:
Zfish   474 --EMLDK---------------------------------------VEPPSIPEGYAMSV----- 492

  Fly   687 KFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLP 751
                                     |||.:                    :.:.|||::.
Zfish   493 -------------------------AFSAL--------------------LDLVRGITNM----- 507

  Fly   752 EEYLSSIYDEISEHEIKMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVS 816
                      |....::.:....|.::.:|....|
Zfish   508 ----------IDRELLRQEQQEAMREEEEPVSPPA------------------------------ 532

  Fly   817 HVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACI---FHM 878
              :.|..:    |..:.|....|...|||.|: |.|....|.||..:  ::..:.:|.:   ..:
Zfish   533 --QEPLAA----EVWQEMVNACWCGLLAALSL-LLDASTDETATENI--LKAELSMASLCGRLGL 588

  Fly   879 SLERDAYVQALAR--------FTLLNAN-------------------SPINE------------- 903
            ...|||::.|:.:        .|:|:::                   ||.:|
Zfish   589 VTPRDAFITAVCKASLPPHYALTILSSSASSLTNKVYSIQGQSVQMVSPSSESHQQVVAVGQPLS 653

  Fly   904 --------MKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIG----TGVRP---- 952
                    :.||||..::||:.:||..|.:||:||        ||.||.|..    .|::|
Zfish   654 AQPQGTVVLTAKNIQCMRTLLNLAHCHGAHLGTSW--------QLVLATLQHLVWILGLKPAPGG 710

  Fly   953 -----QFLSGAQTTLKDSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVS 1012
                 :.:.|..|.|..::         .|....:...:.|:|..|..||..::...:.|||.:|
Zfish   711 VLKPGRAVEGPSTVLTTAV---------MTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLS 766

  Fly  1013 VDELQ-----QQQPRMFSLQKIVEISYYNMERIRLQW----SRIWQVLGEHFNAVGCNSNEEISF 1068
            ::.::     .::|.:|::.|::|....||:||.:.|    :.:.:.:.:|.||    ...|...
Zfish   767 MEAMEMAYGTNKEPSLFAVAKLLETGLVNMDRIEILWRPLTAHLLEKVCQHPNA----RMREWGA 827

  Fly  1069 FALDSLRQLSMKFMEKGEFS-NFRFQKDFLRPFEHIMKKNASPA-IRDMVVRCIAQMVNSQAHNI 1131
            .|:.||.:..:.:......| |.|.|...|.|.:.:  .|...| ||...:.|:.|::.:|..::
Zfish   828 EAITSLIKAGLSYKHDPPLSQNQRLQLLLLNPLKEL--SNVLHADIRQKQLECVLQILQNQGDSL 890

  Fly  1132 RSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFATARFP 1196
            ..||..:..:......|..|.::..|||.            ..::|..|...:.|:
Zfish   891 GPGWPLVLGVIGAIRNDQGESLIRTAFQC------------LQLVVTDFLPTMPCM--------- 934

  Fly  1197 DTSMEAIRLVRTCAQCVHEAPQLFAEHAGMEN---DASVAEEDRVW-------VRG--------- 1242
                        |.|.|.:....|    |::|   :.|:.....:|       .||
Zfish   935 ------------CLQIVVDVAGSF----GLQNQELNISLTSIGLLWNISDYFFQRGEAITEELDK 983

  Fly  1243 -----------------------------WFPMLFSLS--CVVNRCKLDVRTRALTVLFEIVKTY 1276
                                         |..:...|.  ||..|..  ||..|...:|..:..:
Zfish   984 EEAVLLKQAQDKGEPLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPA--VRKSAGQTMFSTIAAH 1046

  Fly  1277 GESFKPHWWKDLFNVIFRIFDNMKLPEHVTEKSEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEE 1341
            |...:|..|    |::.                 |                    .||.|||
Zfish  1047 GTLLQPPTW----NIVV-----------------W--------------------KVLFHLL--- 1067

  Fly  1342 LFAQLHWCVQQSN-----EQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDIFNAT--LPQD 1399
                  .||::|:     |::...|.|.|.:.......|....||..|...:..|||..  |.|.
Zfish  1068 ------DCVRKSSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQQ 1126

  Fly  1400 L----LSWRPKAHSSNNIPQEHNHFEALHIRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAA 1460
            |    .:|        .:..:|....||.....|.|..:::...|:.. .|..|:..:..|.:|.
Zfish  1127 LGDFFKAW--------EVLLDHIQSAALSKNNEVSLAALKSFQEILQL-VTPIKDTDKPDALSAI 1182

  Fly  1461 DLTGGRSGSQSQLLECQREEQGMYGYLRTRQLLTLADCLMQSHRFAKRFNA---------DHDQR 1516
            |:       .|.|:|      .:.|....|.|:. :|.|  :.|.|:|:.|         :.|..
Zfish  1183 DV-------PSVLME------SLQGSGPGRPLVR-SDSL--AERLAQRYAAQPSLPPPGEELDDS 1231

  Fly  1517 SLLWRA 1522
            :|.|.|
Zfish  1232 ALWWSA 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	307/1688 (18%)
		DCB	30..212	CDD:292830	42/181 (23%)
		Sec7_N	312..465	CDD:289549	38/178 (21%)
		Sec7	582..767	CDD:279680	22/185 (12%)
		DUF1981	1080..1161	CDD:286414	20/82 (24%)
mon2	XP_021326251.1	DCB	12..186	CDD:318453	49/251 (20%)
		Sec7_N	218..384	CDD:315455	37/176 (21%)
		DUF1981	<864..919	CDD:312726	13/54 (24%)
		Mon2_C	925..1703	CDD:318446	76/415 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910