DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec71 and arfgef1

DIOPT Version :9

Sequence 1:	NP_609675.2	Gene:	Sec71 / 34785	FlyBaseID:	FBgn0028538	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	XP_009295669.1	Gene:	arfgef1 / 100329953	ZFINID:	ZDB-GENE-030131-108	Length:	1870	Species:	Danio rerio

Alignment Length:	1866	Identity:	1089/1866 - (58%)
Similarity:	1313/1866 - (70%)	Gaps:	237/1866 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPKN 71
            |||.||:.||||||||||:::::|||||:|:|:.|||:||.|..........|:...:.|| |..
Zfish     6 KTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKQESEKLSSPVGDNKSSSSTLP-PIK 69

  Fly    72 DAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTI 136
            ..:|.|.|:.|||||||||:|:.||||:|:||||||||||||||||..|:..||..|||||:.||
Zfish    70 SKSSFIEADKYFLPFELACQSKCPRIVITSLDCLQKLIAYGHLTGSAPDNTTPGKKLIDRIIETI 134

  Fly   137 YGCFSGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLT 201
            .|||.||||||.|||||||||||.||||.:||||.|:||||||||:|||:||||:|||||:||||
Zfish   135 CGCFQGPQTDEGVQLQIIKALLTAVTSQQIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLT 199

  Fly   202 QMLNVIFARMENQVY------------------------------------------------EL 218
            |||||||||||||..                                                |.
Zfish   200 QMLNVIFARMENQALTNHKISWSLASRKRDRQLQEAKQMERERHRQHSPVSQQEPESPGQRHTET 264

  Fly   219 P-----------------------PP--NSNPTNGS--------------------IHSEDCNGS 238
            |                       ||  :..|.|||                    ..:|....:
Zfish   265 PGKTLPAEGNGGPGHQGGKVEQGSPPYESPEPENGSDFCPAENEQTEADQATAAAQSAAEHATEA 329

  Fly   239 GEESLRDSDEVIASELLAEIISAAYN---------------------------EAMKDQESVGEP 276
            .||..|.:.|..|.|::..::....|                           .:::::..:|..
Zfish   330 SEEDERQNYEEKAQEIVESVLLEVVNTVATGNMYVTEMKASHEGEAESAEVSPNSLEEEGGLGSD 394

  Fly   277 EPTLNGNDY-----------SSHSDHDSVELHSENDAVVT------AKFTHILQKDAFLVFRALC 324
            ...::.|..           |...|..||..:...::|.|      |||:||||||||||||:||
Zfish   395 NENVHANGIPGTPISASFTPSLPDDRLSVSSNDTQESVATSGQAPGAKFSHILQKDAFLVFRSLC 459

  Fly   325 KLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVALSNNGVSL 389
            |||||||.||.|||||||||||||||.|||.|||||||:|::|||||.|||||||||||.||||.
Zfish   460 KLSMKPLSDGPPDPKSHELRSKVLSLQLLLSILQNAGPIFKTNEMFINAIKQYLCVALSKNGVSS 524

  Fly   390 VPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFEHKWMVIQALTRICADAQS 454
            ||||||||||||:.||||||.|||.|||||||||||.|||.::||::|||||||.||||||||||
Zfish   525 VPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSYDHKWMVIQTLTRICADAQS 589

  Fly   455 VVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSILKCMVEW 519
            |||||||||||.:|||:|||||||||||||||...|||..|:||.::|.:|||||||||||||||
Zfish   590 VVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGGHELGTTPLQELTLRKKGLECLVSILKCMVEW 654

  Fly   520 SKDLYVNPNMPVPPMQVQSPTSTEQDQADT----------TIQTMHSGSSHSLNSNQEQLQ--DL 572
            |||.|||||......:......:||:..::          :|.::.|.:|..:.|...|:.  |.
Zfish   655 SKDQYVNPNSQTSLGRAGQEKPSEQESNESKHPETINRYGSINSLDSTASSGIGSYSTQMSGTDN 719

  Fly   573 PEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIG 637
            ||..|..|.:||::|.||:|||:||::|:|:|||:.:||.|..|||::||::||||...:|.::|
Zfish   720 PEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSIQVGEFLG 784

  Fly   638 ENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLF 702
            :||..:||||.||:|..||:..:.|.|||..|||||||||||||||||||||:||.|||....||
Zfish   785 DNDRINKEVMYAYVDQMDFQGKDFVPALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLF 849

  Fly   703 QSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEI 767
            .||||.||||:|||||||||||||||:||||||||||||||:||| ||||||||:|||||:..:|
Zfish   850 ASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSK-DLPEEYLSAIYDEIAGKKI 913

  Fly   768 KMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVR 832
            .||....:..:   :.||:..:||:|:||:|:|||.::.||..||::||||::|||||.||||||
Zfish   914 SMKETKELTLK---SNKQSVASEKQRRLLYNVEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVR 975

  Fly   833 PMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNA 897
            ||||:||||||||||||||||||.|:|:|||:||||||||||||.:.||||||||||||||||.|
Zfish   976 PMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTA 1040

  Fly   898 NSPINEMKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQ--- 959
            :|.|.|||.||||||||||.||||||||||:||.:|:||||||||||||||||:.:::||..
Zfish  1041 SSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEIMKCISQLELAQLIGTGVKARYISGTVRGK 1105

  Fly   960 ----TTLKDSLN---------------PSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFV 1005
                |:.|:..:               .|::|.||||||||||||||||||||.||||:||||||
Zfish  1106 EGFITSTKEQTSDEYLGLGGNVDRKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAIVDFV 1170

  Fly  1006 KALCQVSVDEL-QQQQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFF 1069
            :.||.||:||| ....|||||||||||||||||.||||||||||:|:|:|||.||||.||:::.|
Zfish  1171 RWLCAVSMDELASPTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIF 1235

  Fly  1070 ALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSG 1134
            |:||||||||||:||||.:|||||||||||||||||||.||.|||||||||||||||||.|||||
Zfish  1236 AVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVVRCIAQMVNSQAGNIRSG 1300

  Fly  1135 WKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFA-TARFPDT 1198
            ||||||:|||||.|.:|.||||||||||.|:.:::::.|...:|||||||||||||| .|.||||
Zfish  1301 WKNIFSVFHLAASDQDESIVELAFQTTGHIVTNVFEKHFPATIDSFQDAVKCLSEFACNASFPDT 1365

  Fly  1199 SMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPMLFSLSCVVNRCKLDVRT 1263
            |||||||:|.||:.|.:.||.|.::.  .:|.:||.|||||||||||:||.|||::|||||||||
Zfish  1366 SMEAIRLIRHCAKYVSDRPQAFKDYT--SDDMNVAPEDRVWVRGWFPILFELSCIINRCKLDVRT 1428

  Fly  1264 RALTVLFEIVKTYGESFKPHWWKDLFNVIFRIFDNMKLPEHVTEKSEWMTTTCNHALYAIIDVFT 1328
            |.|||:||::||||.:::.|||:|||.::|||||||||||..|||:||||||||||||||.||||
Zfish  1429 RGLTVMFEVMKTYGHTYEKHWWQDLFRIVFRIFDNMKLPEQQTEKAEWMTTTCNHALYAICDVFT 1493

  Fly  1329 QYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDIFN 1393
            |||:.|..:||:::.:||:|||||.||||||||||||||:||.||.|||..||||||.|:||||.
Zfish  1494 QYFESLSDVLLDDILSQLYWCVQQDNEQLARSGTNCLENVVILNGEKFNPETWDKTCNCMLDIFK 1558

  Fly  1394 ATLPQDLLSWRP-----------------------------------------KAHSSN------ 1411
            .|:|..||:|||                                         ||.:.|
Zfish  1559 TTIPHMLLTWRPAGAEGDHMTQLESDKQLDSISQKSVDIQTRSDDQQSVNSMEKALADNRRYSQF 1623

  Fly  1412 ---NIPQEHNHFEALHIRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQL 1473
               :..||...|.||.|:||||||||||:||||||||||:|||||..|.|..|.....
Zfish  1624 SVASEAQEQRLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENFAAAQRDALDAD------- 1681

  Fly  1474 LECQREEQGMYGYLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETS 1538
            :....::||||.||.:.||..|.|||::||||||.||::::||:.||:|||||..||||||||||
Zfish  1682 IHVDTQDQGMYRYLTSEQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETS 1746

  Fly  1539 SLACVLRIFFKMYGDENRRSDWPGIEQELVQVCKEALGYYLSLQSEAHRDAWTSLLLLILTRLLK 1603
            ||||.|||.|:||.|.:||..|..:::.|:.||.:|:.|:|:|.||:||:|||:||||.||::||
Zfish  1747 SLACGLRILFRMYTDPSRRDAWEEVQRRLLNVCSDAVAYFLTLTSESHREAWTNLLLLFLTKVLK 1811

  Fly  1604 MSDARFATHVSNYYSLLCEMMCFDLKPELRSVLRRVFMRIGPVFNI 1649
            :||.||..|.|.||.||||:|.|||.||||:|||:.|:|||.||.|
Zfish  1812 ISDDRFKAHASRYYPLLCEIMQFDLIPELRAVLRKFFLRIGLVFQI 1857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	1037/1789 (58%)
		DCB	30..212	CDD:292830	123/181 (68%)
		Sec7_N	312..465	CDD:289549	130/152 (86%)
		Sec7	582..767	CDD:279680	125/184 (68%)
		DUF1981	1080..1161	CDD:286414	69/80 (86%)
arfgef1	XP_009295669.1	PLN03076	15..1830	CDD:215560	1063/1828 (58%)
		DCB	29..210	CDD:292830	123/181 (68%)
		Sec7_N	447..601	CDD:289549	131/153 (86%)
		Sec7	729..913	CDD:279680	125/184 (68%)
		DUF1981	1246..1327	CDD:286414	69/80 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582785
Domainoid	1	1.000	612	1.000	Domainoid score	I183
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4687
Inparanoid	1	1.050	2089	1.000	Inparanoid score	I41
OMA	1	1.010	-	-		QHG54931
OrthoDB	1	1.010	-	-		D50759at33208
OrthoFinder	1	1.000	-	-		FOG0001583
OrthoInspector	1	1.000	-	-		otm26363
orthoMCL	1	0.900	-	-		OOG6_100729
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1314
SonicParanoid	1	1.000	-	-		X714
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800