DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG16863 and ZBED1

DIOPT Version :9

Sequence 1:NP_001036361.1 Gene:CG16863 / 34784 FlyBaseID:FBgn0028931 Length:661 Species:Drosophila melanogaster
Sequence 2:NP_001164606.1 Gene:ZBED1 / 9189 HGNCID:447 Length:694 Species:Homo sapiens


Alignment Length:762 Identity:153/762 - (20%)
Similarity:269/762 - (35%) Gaps:243/762 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SRSRIWKFYDKLDRNS---------AQCQLCEKVIKTSGNTSNLMKHM-KTHPQINLFDDDVVVE 56
            ::|::||::. .|.|:         ..|::|...|..|||||||..|: |.||            
Human    21 AKSKVWKYFG-FDTNAEGCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHP------------ 72

  Fly    57 RGIYKRREQDDKLRFRKVVPFKEESSDFHSELLFKAAKDASGIIELDDQGMIKAAAEDRISTKSV 121
                                  ||..:|                       :|:..|......:.
Human    73 ----------------------EEFCEF-----------------------VKSNTEQMREAFAT 92

  Fly   122 GYAWVSPEATVSRTETVGGDDIIEFEPKEELDESEKSPLPQIHAVPFAGH--DNLKMEEPLPSES 184
            .::.:.|                         ||.:.|.....||. |||  |:.|.:|...:  
Human    93 AFSKLKP-------------------------ESSQQPGQDALAVK-AGHGYDSKKQQELTAA-- 129

  Fly   185 PFHKDIAFFVCRDRQSLQIVQGEGFQHLVKVLCPTYRPPSAAKLEA-IICRESEAQRSKLCQQLA 248
                 :...:|.......||....|:.|:|...|.|..||...:.. .|..:..|.|..:.::||
Human   130 -----VLGLICEGLYPASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAVREVILKELA 189

  Fly   249 DISTLSLSCSV-HTNAESRSWMELVAHF---------HEGRQRISRTLSVLRLPDLFTSNDLVDR 303
            :.:...:|..: .:..::|:::.|.|||         ..|    ||.|....:|:..|:..:...
Human   190 EATWCGISTDMWRSENQNRAYVTLAAHFLGLGAPNCLSMG----SRCLKTFEVPEENTAETITRV 250

  Fly   304 MDQVCQRFDIPKSRICCVST-------RSSQLLEDAVTSFMGAHHHVPCFADQLNSILEEVVQRP 361
            :.:|...:.| .:::...:|       ::..||:.||        |:||.....|:.:::..|.|
Human   251 LYEVFIEWGI-SAKVFGATTNYGKDIVKACSLLDVAV--------HMPCLGHTFNAGIQQAFQLP 306

  Fly   362 EIRHLRDKVRSHVQSTLQLNPQLDSIHRPISVYNMLDLYLKQ----------------------- 403
            ::..|..:.|..|:...|            |...|..||.||                       
Human   307 KLGALLSRCRKLVEYFQQ------------SAVAMYMLYEKQKQQNVAHCMLVSNRVSWWGSTLA 359

  Fly   404 --------------TLVQEP----LPLSTSEVDLCQQLLDVLRPLTSSMRELSRTPYPAASTALP 450
                          .||::.    |.|..||....:.|:::|:|.......||.:.||..|...|
Human   360 MLQRLKEQQFVIAGVLVEDSNNHHLMLEASEWATIEGLVELLQPFKQVAEMLSASRYPTISMVKP 424

  Fly   451 IAQTLIN---ELKQEKSAEHMVAREIRLFLVQQLEEIF-ERMERNLHLALASLLDPRFRNIPFRS 511
            :...|:|   .:|:..|.|..:|:|:   :.::|.:.: |..|.::.|.:|:.||||::.:||.|
Human   425 LLHMLLNTTLNIKETDSKELSMAKEV---IAKELSKTYQETPEIDMFLNVATFLDPRYKRLPFLS 486

  Fly   512 GALVAQYMTQLYDMMQAHVDS--------GEQAVAKHPENRDHYDIWAAFKSFSHGKQRIVNGSN 568
            .....|...::.:..:..:|.        .|..:...||...              .::::..|.
Human   487 AFERQQVENRVVEEAKGLLDKVKDGGYRPAEDKIFPVPEEPP--------------VKKLMRTST 537

  Fly   569 GPEA---DDEIARYFC--AGMST----------------------LRADPFQLWEELAEAHPFLH 606
            .|.|   ::.:|..||  .|:..                      |..||.:.|.:.....|.|.
Human   538 PPPASVINNMLAEIFCQTGGVEDQEEWHAQVVEELSNFKSQKVLGLNEDPLKWWSDRLALFPLLP 602

  Fly   607 NVAQRYLHVPATAEPADRLFTAEGAAVAAQYARLIENNMENILFMAE 653
            .|.|:|..|.||....:|||.:....|:|:..||...:::..:|:.|
Human   603 KVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLYE 649

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16863NP_001036361.1 zf-BED 4..44 CDD:280965 17/49 (35%)
ZBED1NP_001164606.1 zf-BED 23..72 CDD:280965 17/49 (35%)
Required for interaction with human adenovirus early E1A protein. /evidence=ECO:0000269|PubMed:25210186 315..694 76/364 (21%)
DUF4413 412..>480 CDD:291070 21/70 (30%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17209048 530..534 0/3 (0%)
Required for DNA binding. /evidence=ECO:0000269|PubMed:17209048 552..624 18/71 (25%)
Required for nuclear localization and homodimerization. /evidence=ECO:0000269|PubMed:17209048 571..651 21/79 (27%)
Dimer_Tnp_hAT 571..650 CDD:283379 21/79 (27%)
Required for the formation of higher order complexes of ZBED1 with consensus DNA binding sequences. /evidence=ECO:0000269|PubMed:17209048 652..694
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 68 1.000 Domainoid score I9743
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 121 1.000 Inparanoid score I4760
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46645
OrthoDB 1 1.010 - - D223749at2759
OrthoFinder 1 1.000 - - FOG0012423
OrthoInspector 1 1.000 - - otm40863
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR46169
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
88.080

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