DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16863 and Zbed6

DIOPT Version :9

Sequence 1:	NP_001036361.1	Gene:	CG16863 / 34784	FlyBaseID:	FBgn0028931	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001160024.1	Gene:	Zbed6 / 667118	MGIID:	3828086	Length:	980	Species:	Mus musculus

Alignment Length:	759	Identity:	162/759 - (21%)
Similarity:	275/759 - (36%)	Gaps:	191/759 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRIWKFY--DKLDRNSAQCQLCEKVIKTSG-----NTSNLMKHMK-THP----QINLFDDDVVVE 56
            |.:|.|:  |....:.|.|.:|::.:....     .||.|.:|:: |||    ..|  .|...:.
Mouse   268 SAVWNFFYTDPQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQATHPIHWAVAN--KDSGAIG 330

  Fly    57 RGIYKRREQDDKLRFRKVVPFKEESSDFHSELLFKAAKDASGIIELDDQGMIKAAAEDRISTKSV 121
            .|:      |:.         :.||||..::.:  ..:.:||..:|        .|||
Mouse   331 NGL------DET---------ETESSDLLNDTM--PGEKSSGSQDL--------TAED------- 363

  Fly   122 GYAWVSPEATVSRTETVGGDDIIEFEPKEELDESEKSPLPQIHAVPFAGHDN-LKMEEPLPSESP 185
                      :|.::|       :..|..|::...:||      :|.|..|| :..:|   .|:.
Mouse   364 ----------LSDSDT-------DEPPCLEVENRSESP------IPVADQDNPVHAQE---RETT 402

  Fly   186 FHKDIAFFVCRDRQSLQIVQG-----------------EGFQHLVKVLCPTYRPPSAAKLEAIIC 233
            .|       |.:..:.||.|.                 ..||..::::.|.||.||    |....
Mouse   403 TH-------CENAAANQISQAVIQMIVEDLHPYNYFSTPAFQRFLQIVAPDYRLPS----ETYFF 456

  Fly   234 RESEAQ-----RSKLCQQLADIST--LSLSCSVHTNAESRSWMELVAHF---------HEGRQRI 282
            .::..|     |.|:...|.::.:  :.|:..:.|:..|..:..:..|:         ..|....
Mouse   457 TKAVPQLYDSVREKIFLTLENVQSQKIHLTADIWTHDPSTDYFIVTVHWVSLETASSPSNGGTPN 521

  Fly   283 SRTLSVLRL----PDLFTSNDLVDRMDQV----CQRFDIPKSRICCVSTRSSQLLEDAVTSFMGA 339
            .|..:||.:    .|...:|.|.:..||:    ...|..|.   ..||..||.::. |:..  |.
Mouse   522 FRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLTPS---FIVSDNSSNVVH-AIKG--GG 580

  Fly   340 HHHVPCFADQLNSILEE------------VVQRPEIRHLRDKVRS-----HVQSTLQL---NPQL 384
            ..|||||...||.::::            |..|....|....|::     ..|:..||   |.:.
Mouse   581 FTHVPCFLHCLNIVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQILQEFQNDHQLPWKNLKQ 645

  Fly   385 DSIHRPISVYNMLDLYLKQTL-VQEPL------PLSTSEVDLCQQLLDVLRPLTSSMRELSRTPY 442
            |.....||.:.||...|:... |...|      .|::.:..|...:.|:|:|...:.:.:| ...
Mouse   646 DETGHWISTFYMLKWLLEHCYSVHHSLGRASGVVLTSLQWTLMTYVCDILKPFEEATQRVS-VKT 709

  Fly   443 PAASTALPIAQTLINELKQEKSAEHMVAREI--RLFLVQQL------EEIFERMERNLHLALASL 499
            ...:..||:...|:..|  ::..|....|.|  .|.||..|      :.:...|.::.|..||:|
Mouse   710 TGLNQVLPLIHHLLFSL--QRLREDFQVRGITQALNLVDSLSLKLESDALLSAMLKSKHCILATL 772

  Fly   500 LDPRFRNIP---FRSGALVAQYMTQLYDMMQAHVDSGEQAV------AKHPENRDHYDIWAAFKS 555
            |||.|:|..   |..||.:..|...|.:.:..:::|...|.      ...|..|...|.:.:.|.
Mouse   773 LDPCFKNSLEDFFPQGADLETYKQILAEEVCNYMESSPGACQISSSETSGPLVRLGTDSFTSIKE 837

  Fly   556 FSHGKQRIVNGSNG-----------PEADDEIARYFCAGMSTLRA--DPFQLWEELAEAHPFLHN 607
            .:.....:.:.:.|           |.|...:..||....|.|..  ||...|:......|.|..
Mouse   838 GTSSAGSLDSSAAGSVAVGSKSSLLPAAVAVVDEYFKEKYSELSGGDDPLVYWQRKVSIWPALTQ 902

  Fly   608 VAQRYLHVPATAEPADRLFTAEGAAVAAQYARLIENNMENILFM 651
            ||.:||..|..:..::.:||........|...:..:|:|.::|:
Mouse   903 VAIQYLSCPMCSWQSECMFTTNSHFHPKQIMNMDFDNIEQLIFL 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16863	NP_001036361.1	zf-BED	4..44	CDD:280965	12/47 (26%)
Zbed6	NP_001160024.1	Required for nucleolar localization. /evidence=ECO:0000269\|PubMed:20016685	1..89
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..109
		ZnF_BED	135..182	CDD:214746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..239
		ZnF_BED	270..316	CDD:214746	11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..397		22/123 (18%)
		HATC (Hobo-Ac-Tam3) domain	868..950		20/79 (25%)
		Dimer_Tnp_hAT	870..950	CDD:283379	20/77 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810