DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16863 and ZBED6

DIOPT Version :9

Sequence 1:	NP_001036361.1	Gene:	CG16863 / 34784	FlyBaseID:	FBgn0028931	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001167579.1	Gene:	ZBED6 / 100381270	HGNCID:	33273	Length:	979	Species:	Homo sapiens

Alignment Length:	760	Identity:	162/760 - (21%)
Similarity:	264/760 - (34%)	Gaps:	194/760 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRIWKFY--DKLDRNSAQCQLCEKVIKTSG-----NTSNLMKHMK-THP----QINLFDDDVVVE 56
            |.:|.|:  |....:.|.|.:|::.:....     .||.|.:|:: |||    ..|  .|...|.
Human   267 SAVWNFFYTDPQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQATHPIHWAVAN--KDSGAVA 329

  Fly    57 RGIYK-RREQDDKLRFRKVVPFKEESSDFHSELLFKAAKDASGIIELDDQGMIKAAAEDRISTKS 120
            .|:.: ..|:.|.|           |...|.|                               ||
Human   330 NGLDEAETERSDLL-----------SDTLHGE-------------------------------KS 352

  Fly   121 VGYAWVSPEATVSRTETVGGDDIIEFEPKEELDESEKSPLP----------QIHAVPFAGHDNLK 175
            .|    |.:.|.........|     ||..|::...:||:|          |.......|:
Human   353 TG----SQDLTAEDLSDSDSD-----EPMLEVENRSESPIPVAEQGTLMRAQERETTCCGN---- 404

  Fly   176 MEEPLPSESPFHKDIAFFVCRDRQSLQIVQGEGFQHLVKVLCPTYRPPSAAKLEAIICRESEAQ- 239
                 |..|...:.|...:..|...........||..::::.|.||.||    |.....::..|
Human   405 -----PVSSHISQAIIQMIVEDMHPYNYFSTPAFQRFMQIVAPDYRLPS----ETYFFTKAVPQL 460

  Fly   240 ----RSKLCQQLADIST--LSLSCSVHTNAESRSWMELVAHF---------HEGRQRISRTLSVL 289
                |.|:...|.::.:  :.|:..:.|:..|..:..:..|:         :.||....|..:||
Human   461 YDCVREKIFLTLENVQSQKIHLTVDIWTHDPSTDYFIVTVHWVSLETASFLNNGRIPDFRKWAVL 525

  Fly   290 RL----PDLFTSNDLVDRMDQV----CQRFDIPKSRICCVSTRSSQLLEDAVTSFMGAHHHVPCF 346
            .:    .|...:|.|.:..||:    ...|.||.   ..||..||.::. |:..  |...|||||
Human   526 CVTGLAKDCLITNILQELNDQIGLWLSPNFLIPS---FIVSDNSSNVVH-AIKD--GGFTHVPCF 584

  Fly   347 ADQLNSILEE------------VVQRPEIRHLRDKVRS-----HVQSTLQL---NPQLDSIHRPI 391
            ...||.::::            |..|....|....|::     ..|:..||   |.:.|.....|
Human   585 LHCLNMVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQILQEFQNDHQLPWKNLKQDETGHWI 649

  Fly   392 SVYNMLDLYLKQTL-VQEPL------PLSTSEVDLCQQLLDVLRPLTSSMRELSRTPYPAASTAL 449
            |.:.||...|:... |...|      .|::.:..|...:.|:|:|...:.:::| ......:..|
Human   650 STFYMLKWLLEHCYSVHHSLGRASGVVLTSLQWTLMTYVCDILKPFEEATQKVS-VKTAGLNQVL 713

  Fly   450 PIAQTLINELKQEKSAEHMVAREI--RLFLVQQL------EEIFERMERNLHLALASLLDPRFRN 506
            |:...|:  |..:|..|....|.|  .|.||..|      :.:...|.::....||:||||.|:|
Human   714 PLIHHLL--LSLQKLREDFQVRGITQALNLVDSLSLKLETDTLLSAMLKSKPCILATLLDPCFKN 776

  Fly   507 IP---FRSGALVAQYMTQLYDMMQAHVDSGEQAVAKHPENRDHYDIWAAFKSFSHGKQRIV---- 564
            ..   |..||.:..|...|.:.:..:::|..: :.:.|.:.      |:..|.:.|.....
Human   777 SLEDFFPQGADLETYKQFLAEEVCNYMESSPE-ICQIPTSE------ASCPSVTVGADSFTSSLK 834

  Fly   565 -----NGSNGPEADDEIA----------------RYFCAGMSTLRA--DPFQLWEELAEAHPFLH 606
                 :||....|.|.:|                .||....|....  ||...|:......|.|.
Human   835 EGTSSSGSVDSSAVDNVALGSKSFMFPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPALT 899

  Fly   607 NVAQRYLHVPATAEPADRLFTAEGAAVAAQYARLIENNMENILFM 651
            .||.:||..|..:..::.:||........|...|..:|:|.::|:
Human   900 QVAIQYLSCPMCSWQSECIFTKNSHFHPKQIMSLDFDNIEQLMFL 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16863	NP_001036361.1	zf-BED	4..44	CDD:280965	12/47 (26%)
ZBED6	NP_001167579.1	Required for nucleolar localization. /evidence=ECO:0000250\|UniProtKB:D2EAC2	1..89
		ZnF_BED	135..182	CDD:214746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..232
		ZnF_BED	269..315	CDD:214746	11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..383		16/100 (16%)
		HATC (Hobo-Ac-Tam3) domain	866..948		20/79 (25%)
		Dimer_Tnp_hAT	868..948	CDD:283379	20/77 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40863
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820