DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16863 and znf618

DIOPT Version :9

Sequence 1:	NP_001036361.1	Gene:	CG16863 / 34784	FlyBaseID:	FBgn0028931	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001313621.1	Gene:	znf618 / 100330008	ZFINID:	ZDB-GENE-030131-2063	Length:	827	Species:	Danio rerio

Alignment Length:	749	Identity:	142/749 - (18%)
Similarity:	257/749 - (34%)	Gaps:	159/749 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NSA---QCQLCEKVIKTSGNTSNLMKHMKTHPQINLFDDDVVVERGIYKRREQDDKL-------- 69
            |||   .|.:|.|..|   ..|...:|...|...:.:|..:.|| .:.:..|...|:
Zfish   120 NSAFRYTCDVCGKKYK---YYSCFQEHRDLHAVDDPYDHVIPVE-DLKEEAESFQKMGPKTGSYT 180

  Fly    70 ------RFRKVVPFKEESSDFHSELLFKAAKDASGIIELDDQGMI--KAAAEDRISTKSVGYAWV 126
                  :::...|::|..: .|:.|        .|...|..:|.:  ::....|:...:...:..
Zfish   181 CEYCGKQYKYFNPYQEHVA-LHAPL--------KGTFGLKLEGKLSGQSGQSSRVDINNSHNSSD 236

  Fly   127 SPEA-------TVSRTETVGG--------DDIIEFEPKEELDE----SEKSPLPQIHAVPFAGHD 172
            :|.:       :..:|.|.|.        ::::|.......|.    .|.||.|  ...| ||..
Zfish   237 TPNSRTYTSLPSPQKTYTCGACGIQFQFYNNLLEHMQSHAADNENHVKEDSPKP--CPAP-AGTQ 298

  Fly   173 NLKMEEPLPSESPFH------------------KDIAFFVCRDRQSLQIVQGEGFQHLVKVLCPT 219
            ....:.|.|::...|                  :.:...:|.|...|.::..:.|..|.:.|..|
Zfish   299 EQLWKSPQPAQQRNHMPSFQNRLLPEKERQQVAERLLRVMCVDLGLLGVLSSKDFLKLAQTLVDT 363

  Fly   220 YRPPSAAKLEAIICRESEAQRSKLCQQ----------------LADISTLSLSCSVHTNAESRSW 268
                 .::..|...||:....|.|..:                |...|:|.::.:.|:.......
Zfish   364 -----GSRNGAYSIREALGDMSSLALKQLPRMYNQVKVKVTCALGSNSSLGIAVTCHSQTVGPDS 423

  Fly   269 MELVAHFHEGRQRISRTLSVLRLPDLFTSNDLVDR-MDQVCQRFDIPKSRICCVS-TRSSQLLED 331
            ..|:..:.....|:.|.:..|:...|..|.:.:.. :..|...|.:.:.|...|: .|.|.|...
Zfish   424 CYLLTAYQVEGVRLRRYVLGLKEASLRESPEQIHHWVQNVLSEFVMSEIRTVYVTEPRLSSLTFC 488

  Fly   332 AVTSFMGAHHHVPCFADQLNSILEEVVQR--------PEIRHLRDKVRSHVQSTLQLNPQLDSIH 388
            ..|...     :.|....|.:.::.|:.|        .|:..|....|. :.:|...|.:..:..
Zfish   489 GRTGIC-----LRCAGCSLTATVQAVLGRRSLQARGLHELGELLATCRD-IAATTSFNHEGKTAE 547

  Fly   389 RPIS-------VYNMLDLYLKQTLVQEPLPLSTSEVDLCQ--------QLLDVLRPLTSSMRELS 438
            .|.:       ...:|.::.......|....|.|.|.|.|        .|..:|.||..:..|||
Zfish   548 DPAAPPCWDAVAEALLKVHENFEATCEAYGRSKSTVPLLQGLNKHLLGTLACLLAPLRQAALELS 612

  Fly   439 RTPYPAASTALPIAQTLINELKQEKSAEHMVAREIRLFLVQQLEEIFERMERNLHLALASLLDPR 503
            ....|.....||:...| .:|...|:.|.....::..:.::.|:|.| ::|| :| .:|.:|||:
Zfish   613 LERCPTLQNVLPVYLRL-EKLFTSKAGEAGAGSKLCHYFLEALKENF-KVER-VH-QVAMILDPQ 673

  Fly   504 FRNIPFRSGALVAQY-----MTQLYDMMQAHVD--SGEQAVAKHPE---------NRDHYDIWAA 552
            .:..|      |..|     ::::.||..:..|  ||..|.|...|         .|...|.
Zfish   674 LKLRP------VPAYQHEEIISRVCDMAASMRDLGSGGSAGASVDERDGEGPSAPKRGRLDC--- 729

  Fly   553 FKSFSHGKQRIVNGSNGPEADDEIARYFCAGMSTLRADPFQLWEELAEAHPFLHNVAQRYLHVPA 617
                  |..|....:..|:...|:.:|....:.:...|..|.|..:.:.:|.|..:|...|.|||
Zfish   730 ------GLDRPSCDAEEPQVRKELFQYLGEPLFSGTGDLLQYWSSVMDRYPRLSRLALWLLAVPA 788

  Fly   618 TAEPADRLFTAEGAAVAAQYARLIENNMENILFM 651
            .|...:.:...|......:..::....|..::|:
Zfish   789 VAVHGECMSICEQTLAMKRKQQVTAEEMNKLVFL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16863	NP_001036361.1	zf-BED	4..44	CDD:280965	9/30 (30%)
znf618	NP_001313621.1	C2H2 Zn finger	83..103	CDD:275368
		C2H2 Zn finger	127..147	CDD:275368	6/22 (27%)
		Dimer_Tnp_hAT	746..>788	CDD:283379	10/41 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900