DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16863 and mybl2a

DIOPT Version :9

Sequence 1:	NP_001036361.1	Gene:	CG16863 / 34784	FlyBaseID:	FBgn0028931	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001296755.1	Gene:	mybl2a / 100005189	ZFINID:	ZDB-GENE-980526-529	Length:	802	Species:	Danio rerio

Alignment Length:	806	Identity:	151/806 - (18%)
Similarity:	252/806 - (31%)	Gaps:	275/806 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WKFYDK--LDRNSAQCQ------LCEKVIKTSGNTSNLMKHMKTH-------PQINLF-----DD 51
            |....|  ..|...||:      |...||||....:..:..:|.|       .||..|     |:
Zfish   102 WSIISKNLKGRRGKQCRERWHNHLDPSVIKTPWTAAEDLIIIKCHCLLGSRWAQIAKFLPGRTDN 166

  Fly    52 DV----------VVERGIYKRREQDDKLRFRKVVPFKEESSDFHSELLFKAAKDASGIIELDDQG 106
            .:          .:|||.||...                                   ::|.|.|
Zfish   167 SIKNHWYSTLKRKMERGTYKMES-----------------------------------LDLSDLG 196

  Fly   107 MIKAAAEDRISTKSVGYAWVSPEATVSRTETVGGDDIIEFEPKEE--LDESEKS---PLPQIHAV 166
            ..:.:.|  .||.|      |||...|..|.:.     :.:|.:.  |:.|.|:   ||....:.
Zfish   197 HHQKSKE--TSTSS------SPEKLKSTPEPLS-----KTKPTKSMFLENSLKANGPPLYNCSSS 248

  Fly   167 PFAGHDNLKMEEPLPSESPFHK----DIAFFVCRDRQSLQIVQGEGFQHLVKVLCPTYRPPSAAK 227
            |.:.      ..| |:..|.||    |:...:..|...|...:|.||:..:..:.|.:...|...
Zfish   249 PSSS------SSP-PTVPPQHKAYVDDVLQMIAEDMLPLNFCEGCGFRKFMSSVGPQHPQLSQQM 306

  Fly   228 LEAIICRESEAQ-RSKLCQQLADISTLS-------LSCSVHTNAESRSWMELVAHFHE------- 277
            :.:.:..|.|.. :.:|.:||.:..:||       ::..:..|..:.:.:.:..||.:
Zfish   307 IASHLYNEVEKTIKPRLIRQLRNCISLSVGHNVVHVTADIWANEHTETLLAVQLHFLDDDWNLHR 371

  Fly   278 -------------GRQRISRTLSVLRLPDLFTSN----------DLVDRMDQVC--------QRF 311
                         ...||....|||....||..|          :.:...|..|        |:.
Zfish   372 PTVAFRHLSSKELNTTRIGEVESVLLSYGLFPHNIGYSMIHEAKNTISTHDLFCDYKIMYSAQKN 436

  Fly   312 DIPKSRICCVSTRSSQLLED--AVTSF----MGAHHHVPCFADQLNSILEEVVQRPEIRHLRDKV 370
            |..:..:.       :.|:|  |:..|    |.:..|:.|....|:.:::..:::..:   .:::
Zfish   437 DPDEDELL-------RFLDDQVAIDDFSIAEMSSTKHLDCITTLLHCVIKGALRKSRV---VERI 491

  Fly   371 RSHVQSTLQLNPQLDSIHRPISVYNMLDLYLKQTLVQEPLPLSTSEVDLCQQLLDVLRPLTSSMR 435
            ...|||.:       |..|. |.| .||:..|:..:......|||.: .....:.::|.:
Zfish   492 LFEVQSVV-------SFFRR-SPY-WLDVLTKKCKLSLCGSYSTSSL-TWNSTISIIREM----- 541

  Fly   436 ELSRTPYPAASTALPIAQTLINELKQEKSAEHMVAREIRLFLVQQLEEIFERMERNLH------- 493
             :..:.:......|..|:|..|.......|.| ||||..:.||..||. ||.:.:.|.
Zfish   542 -MQESVWDTVMAVLIQARTEANHCHISPPAIH-VAREQVVDLVTLLEP-FEEVVQLLQDDGITLS 603

  Fly   494 -------------------------------------------LALASLLDPRFRNIPF------ 509
                                                       |.||::||||.:..||
Zfish   604 LIIPSIIGLDKTLEIKDTKFSLFCSALRCGLRTYFQPLILRSDLLLATVLDPRIKLQPFDCEKEQ 668

  Fly   510 ------------RSGALVAQYMTQLYDMMQAHVDSGEQAVAKHPENRDHYDIWAAFKSFSHGKQR 562
                        |..::|...:...|...:...|......:...:...||
Zfish   669 FKSTLLFVPSKQRVSSVVESALGDAYTAAEMSCDKTADLQSSIVQELHHY--------------- 718

  Fly   563 IVNGSNGPEADDEIARYFCAGMSTLRADPFQLWEELAEAHPFLHNVAQRYLHVPATAEPADRLFT 627
                .:.|.||..::..             ..|:..|.... |.:|.:..|.|||::....|||.
Zfish   719 ----LSEPLADGSVSLQ-------------DFWKGAARFSQ-LQSVCRTLLAVPASSGGFRRLFP 765

  Fly   628 AEGAAVAAQYARLIENNMENILFMAE 653
            .....|.||.:||.::..|.:|...|
Zfish   766 LASRIVRAQRSRLPQHTTERLLLYRE 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16863	NP_001036361.1	zf-BED	4..44	CDD:280965	12/51 (24%)
mybl2a	NP_001296755.1	SANT	27..75	CDD:197842
		Myb_DNA-bind_6	30..90	CDD:290632
		SANT	79..127	CDD:197842	6/24 (25%)
		Myb_DNA-bind_6	82..139	CDD:290632	10/36 (28%)
		SANT	131..178	CDD:197842	8/46 (17%)
		Myb_DNA-binding	131..176	CDD:278669	8/44 (18%)
		Dimer_Tnp_hAT	714..787	CDD:283379	22/105 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.770