DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16863 and zbed4

DIOPT Version :9

Sequence 1:	NP_001036361.1	Gene:	CG16863 / 34784	FlyBaseID:	FBgn0028931	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001076410.1	Gene:	zbed4 / 100000808	ZFINID:	ZDB-GENE-041210-305	Length:	1249	Species:	Danio rerio

Alignment Length:	802	Identity:	152/802 - (18%)
Similarity:	264/802 - (32%)	Gaps:	252/802 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSRIWKFY--DKLDRNSAQCQLCEKVI----KTSGNTSNLMKH-MKTHPQINLFDDDVVVERGIY 60
            :|.:|..:  ..:|:..|.|:.|..||    :....||.||:| |:.||.:            :.
Zfish   536 KSEVWHHFIVSPVDQLKALCRYCPCVISRGKRGDFGTSCLMRHLMRRHPDV------------LK 588

  Fly    61 KRREQDDKLRFRKVVPFKEESSDFHSELLFKAAKDASGIIELDDQGMIKAAAEDR-----ISTKS 120
            ..:...||:...:.......:.|..::.|                     |||::     |.:|.
Zfish   589 TPKSTSDKVSSPQSPHSNHAAEDLATDTL---------------------AAENKPHTLPIFSKK 632

  Fly   121 VGYAW-------VSP--------EATVSR--------------------------TETVGGD-DI 143
            ....|       ..|        ..|:||                          ...:.|| ..
Zfish   633 TSKLWNHFSISSADPTKVVCLHCSRTISRGKKTTNLGTSCLFRHMQRFHGHVLENNSNISGDGPS 697

  Fly   144 IEFEPKEEL-------DESEKSPLPQIHAVPFAGHDNLKMEEPLPSESPFHKDIAFFVCRDRQSL 201
            .|.:.|:||       :.:|                  |..|..|:.....|.||..:..|.|..
Zfish   698 AETQVKQELMDISTYQENAE------------------KFSECHPAAKKITKLIAEMLALDLQPS 744

  Fly   202 QIVQGEGFQHLVKVLCPTYR-PPSAAKLEAIICRESEAQRSKLCQQL--ADISTLSLSCSVHTNA 263
            .:|:..|...|::.|.|.|. |||:......|....|:.:..:...|  |:...:..:.||...:
Zfish   745 TVVENVGLNRLLEYLQPQYSLPPSSYFTSTAIPEMYESVKEVVLTHLKEAEGGIIHFTTSVWIGS 809

  Fly   264 ESRSWMELVAHFHEGRQRISRTLSVLRLPDLFTSNDLVDRMDQVCQRFDIPKSRICCVSTRSSQ- 327
            :::.::.|.||:      :|           |.|..|....|..|.......|..|..:..:.|
Zfish   810 QTQEYLILTAHW------VS-----------FESQVLPQGQDFHCSALLGVASIDCDYNMLNIQK 857

  Fly   328 LLEDAVTSFMGA-----------------------HHHVPCFADQLNSILEEVVQRPEIRHLRDK 369
            .||....::||:                       |..:.||...::.|:.|.:          |
Zfish   858 QLEYLWDTWMGSSGLKIGFTVTDNQTIRNVLESCDHTTMQCFVHNIDLIVNEAI----------K 912

  Fly   370 VRSHVQSTLQLNPQL-DSIHRPISV-----------------------------YNMLDLYLKQT 404
            .:..||:.|.:..:: :.:||....                             |.||:..::|.
Zfish   913 SQRMVQNLLSIARKICERVHRSAKAKEKLAELQKVYQLPENQLVQDVPSKWKTSYFMLERLVEQK 977

  Fly   405 LVQEPLPLSTS--EVDLCQQ------LLDVLRPLTSSMRELS-RTPYPAASTALPIAQTLINELK 460
            ...:.:.:..:  |:..|.|      :.:.|:|...:.||:| ||  ......:|:.
Zfish   978 KAIDEMSIECNFRELISCDQWEVMGSVCNALKPFVVACREMSNRT--ATLGQVIPLI-------- 1032

  Fly   461 QEKSAEHMVAREIRLF---------LVQQLEE-IFERMERNLH---LALASLLDPRFRNIPFRSG 512
                  |::.|:|.:.         :::.|:| :..||...||   ...|::||||::...|
Zfish  1033 ------HILNRKIDMLFDETMGIDNMLKSLKEALVTRMSPTLHDPRYIWATMLDPRYKTSLF--- 1088

  Fly   513 ALVAQYMTQL-YDMMQ-AHVDSGEQAVAKHPENRDHYDIWAAFKSFSHGK-----------QRIV 564
              ..:...|. :|::| ..|.:...|..|.|.:....:|.|:..|.:..|           |:|.
Zfish  1089 --TEEEAEQCKHDLIQELEVSTSNSAETKTPLSNGCSEIPASSNSLASNKENLWSLMDDIRQKIK 1151

  Fly   565 NGSNGPEADDEIARYFCAGMSTLRADPFQLWEELAEAHPFLHNVAQRYLHVPATAEPADRLFTAE 629
            ........:..:..|....:.....||...|.......|.|..||.||:..|.:..|||.||:..
Zfish  1152 QEEKPKSLELAVLEYLEEDILDQSCDPLDYWNLKKLLWPDLAKVAVRYVGCPPSIVPADTLFSTS 1216

  Fly   630 GAAVAAQYARLIENNMENILFM 651
            ....|...:|.:..|.|.:||:
Zfish  1217 TVNCALNQSRPLLENFEGLLFL 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16863	NP_001036361.1	zf-BED	4..44	CDD:280965	14/46 (30%)
zbed4	NP_001076410.1	zf-BED	205..253	CDD:280965
		zf-BED	368..414	CDD:280965
		ZnF_BED	538..586	CDD:214746	15/47 (32%)
		zf-BED	634..681	CDD:280965	5/46 (11%)
		Dimer_Tnp_hAT	1165..1242	CDD:283379	22/74 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820