DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and ABCA2

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_190357.2	Gene:	ABCA2 / 823927	AraportID:	AT3G47730	Length:	983	Species:	Arabidopsis thaliana

Alignment Length:	835	Identity:	200/835 - (23%)
Similarity:	346/835 - (41%)	Gaps:	181/835 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 PGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLR-PNNNSFEMQLEMEQQCRGSCFAIDFHRV 133
            ||..:      ||. .|...:|...||..::...|. |....|     :|:......:.|..:..
plant   115 PGRSI------PIE-KVRSFVDPEAVDTWLMANPLLVPGALHF-----IERNATVISYGIQTNST 167

  Fly   134 P--NRG--SDRKFRYSLSSNQMRISPRKRFVNDEEIYHQIDDDDYIR--SGFLSLQHILDKQYMK 192
            |  |||  .|..|::.:   .::|:.      :.||...:..|....  .||....|
plant   168 PEMNRGRFEDPTFKFQI---PLQIAA------EREIARSLIGDPNFNWVVGFKEFPH-------- 215

  Fly   193 YQELGKDFEVVVSSMPNME-VISMDSHRLTYFGTLCSILFNVVL-LSSFVVPFVEEKQNGLKEFL 255
                           |.:| ::::|:...|:|  |...:|..|| :||.:.    ||:..|::.:
plant   216 ---------------PTIEAIVALDTIGPTFF--LAVAMFGFVLQISSLIT----EKELKLRQAM 259

  Fly   256 NLVTPMS---FLNGLTF-FLIRFVCYTLLMIFVLVVAYLYKALGSICFAYVAVLFLLYILSTMSY 316
            .::....   :|:.||: .::..:...|.::|.::..:.:....|  |..|.:||:|:..:.:..
plant   260 TMMGVFDTAYWLSWLTWEGILTAISALLTVLFGMMFQFDFFLKNS--FPVVFLLFMLFQFNLIGL 322

  Fly   317 AYLISICFHSVFYAKIGGLAMLIIPYAFSFVRSWATSLAF--------------VCFSTNTFLEG 367
            |:::|........|...|..:.::    .||...|||..|              ..|..|||.:|
plant   323 AFMLSAFISKSTSATTVGFFVFLV----GFVTQLATSSGFPYAKKYSRMIRALWSLFPPNTFSQG 383

  Fly   368 LDIFQTFSNK--------RKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVF 424
            |.:....::.        .|..|.|..|....:    .|:..:|:.|:...||:.:|..|...:.
plant   384 LKLLADATSTPQDPGISWSKRAECGPNDDTGCV----LTINDIYLWLLGTFFLWFVLALYFDNIT 444

  Fly   425 PGPGGLKRPMFFFLDP---------------------------------------KTYMKRQRNE 450
            |...|:::.:|:||.|                                       :|.:|:...|
plant   445 PNASGVRKSIFYFLKPGYWTGKGGNRVEEGGICSCIGSVPPVDHITPDDEDVLEEETLVKQHSME 509

  Fly   451 YTTTPRGTHAIIITEL------------CKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGK 503
            ....|  ..|:.|..|            ||..:||....|  ..|.|.|...::..|||.|||||
plant   510 GLVDP--NVAVQIRGLAKTYPGTTKFGCCKCKKTSPFHAL--KGLWMNIAKDQLFCLLGPNGAGK 570

  Fly   504 TTMMNMIMGLVPKDSGKIIVC-----SERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRG 563
            ||.:|.:.||.|...|..::.     |...:::.|.:||.|||..:....::..:||:.||.::|
plant   571 TTTINCLTGLFPVTGGDALIYGNSIRSSVGMSNIRKMIGVCPQFDILWDALSGEEHLKLFASIKG 635

  Fly   564 ACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSR 628
            ...|......::.|.::.|::.......:.|||||||||:.:::.|:.|:|.||||::|:|..:|
plant   636 LPPSSINSMVEKSLAEVKLTEAGKIRAGSYSGGMKRRLSVAVSLIGDPKLVFLDEPTTGMDPITR 700

  Fly   629 RELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL--- 690
            |.:|||:...:|.:|:::|||.||||::|.|.|.|:|.|:|:.||:.:.||.:.|.|:...:
plant   701 RHVWDIIQETKKGRAIILTTHSMEEADILSDRIGIMAKGRLRCIGTSIRLKSRFGTGFIANISFV 765

  Fly   691 EINDFT------SREVEIMEIIHHFVPTARVLNVVNPTVYI--CLPYAYKNCFAQMLYRLETESK 747
            |.|:..      |||    .:...|....:|..:.....::  .:|:..:|........|:...:
plant   766 ESNNHNGEAGSDSRE----PVKKFFKDHLKVKPIEENKAFMTFVIPHDKENLLTSFFAELQDREE 826

  Fly   748 ELGIHTISMTDTSLEDVFLRCA-----------GEQDQVDTPDGSRNDAPLLAHY 791
            |.||..|.:...:||:|||..|           |....:|...||..:.|:.|.:
plant   827 EFGISDIQLGLATLEEVFLNIARKAELESAAVDGTMVTLDLTSGSSVEIPVGARF 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	28/143 (20%)
		CcmA	460..767	CDD:224054	104/334 (31%)
		ABC_subfamily_A	461..679	CDD:213230	81/234 (35%)
		ABC2_membrane_3	<937..1117	CDD:289468
		ABC_subfamily_A	1255..1479	CDD:213230
		drrA	1262..1573	CDD:130256
ABCA2	NP_190357.2	rim_protein	<186..>861	CDD:130324	175/727 (24%)
ABCA2	NP_190357.2	ABC_subfamily_A	518..751	CDD:213230	81/234 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820