DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and abca4a

DIOPT Version :10

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:NP_001428973.1 Gene:abca4a / 798993 ZFINID:ZDB-GENE-050517-3 Length:2306 Species:Danio rerio


Alignment Length:1956 Identity:498/1956 - (25%)
Similarity:805/1956 - (41%) Gaps:534/1956 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 WSVKPVLHQINQF--EAKNEMV-------LRELYFPGNE-LDYIYYSPISPNVEDIMDLLRVDLG 98
            ||......|||..  ..:|..|       ||...|.|.. |:::|..|.....:|:         
Zfish   439 WSFFQDSVQINMLRDSIRNPTVMDHINKGLRNAAFTGQHILNFLYSGPEEDREQDM--------- 494

  Fly    99 IIPERLRPN---NNSFEMQLEMEQQCR-----GSCFAID-----------FHRVPNRGSDRKF-- 142
                   ||   .|.|.:   .:|..|     |.|..:|           .||..|...:.||  
Zfish   495 -------PNFDWRNIFNL---TDQVIRLINRYGECLVLDKFSSISDEDQLTHRALNLLEEGKFWA 549

  Fly   143 ------RYSLSSN---------QMRISPRKRFVNDEEIY-------HQIDDDDYIRSGFLSLQHI 185
                  .||.::.         :|.|...:|....::.|       ..:||..||..||..||.:
Zfish   550 GLVFVDMYSWTTKVPPHVKVKIRMDIDVVERTNKIKDRYWDPGPRADPMDDLRYIWGGFAYLQDM 614

  Fly   186 LDKQYMKYQELGKDFE--VVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVL----LSSFVVPFV 244
            ::...:| ...||::.  |.:..||....:. |...||.  ..|..:|.|:.    :|..|...|
Zfish   615 IEHGIIK-THTGKEWPLGVYLQQMPYPCYVD-DLFMLTL--NRCFPIFMVLAWVYSVSMTVKSIV 675

  Fly   245 EEKQNGLKEFLNLVTPMSFLNGLTFFLIRF---VCYTLLMIFVLVVAYLYKALGSICFAY----V 302
            .||:..|||.|..:...:.:...|:|:..|   ...|.|:..::        :|.....|    :
Zfish   676 LEKEMRLKETLKAMGVTNRVLWCTWFIDTFFMMASSTALLTLII--------MGGKVLNYSNPII 732

  Fly   303 AVLFLL-YILSTMSYAYLISICFHSV-FYAKIGGLA--MLIIPYAFSFVRSW-----------AT 352
            ..|||| :..:|:...:|:|:.|:.. ..|...|:.  .|.:|:...|  :|           |:
Zfish   733 LFLFLLTFTTATIMQCFLMSVFFNKANLAAACSGIIYFTLYLPHVVCF--AWQDRITKDMKIMAS 795

  Fly   353 SLAFVCFSTNT-FL-----EGL----DIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLV 407
            .::.|.|...| :|     :||    |..||                .:::.:..:..:..:::.
Zfish   796 LMSQVAFGFGTEYLSRYEEQGLGLQWDNIQT----------------SLLEGDEFSFLNSIIMMA 844

  Fly   408 FQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKR-------------------------- 446
            ..:.||.:|..||..||||..|:.||.:|.:.|..::.|                          
Zfish   845 VDTVLYGVLAWYLDSVFPGQYGIGRPCYFPIQPSYWLNRPEPLKQVPGKPTVEKPAFDNLVNNTD 909

  Fly   447 -QRNEYTT--------------------------------------------------TPRGTHA 460
             |...:|.                                                  .|.|..|
Zfish   910 DQAKNHTAPEKPPEPPGSCKHGDIREKLEREKLQKRIVEEEINRSMSTDSSGKVFFEPEPSGLVA 974

  Fly   461 -IIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVC 524
             :.:..|.|.|..|.|..:  |.|::|....:||..||||||||||.|:::.|:.|..||...:.
Zfish   975 GVCVENLYKVFSGSSRPAV--DGLSLTFYEGQITAFLGHNGAGKTTTMSVLTGMFPPTSGTAYIY 1037

  Fly   525 SE---RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKR 586
            .:   .|:.:.|..:|.||||::...:||..:|:.|::.|:|....:|:...:..|:.|||..||
Zfish  1038 GKDIRTDMDAIRKSLGMCPQHNIIFHHMTVAEHILFYSLLKGRPLPEAQLEVENMLEDLGLPHKR 1102

  Fly   587 NEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYM 651
            ||..:||||||:|:||:.:|..|..|:|.||||:||:|..|||.:||:||..|..:.::::||:|
Zfish  1103 NEEAQNLSGGMQRKLSVAMAFVGGAKVVFLDEPTSGVDPYSRRSIWDLLLKYRAGRTLILSTHHM 1167

  Fly   652 EEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRL---------------------------- 688
            :||::|.|.:.|::.|:|...||||.||...|.|:.|                            
Zfish  1168 DEADLLSDRVAIISQGRLYCCGSPLFLKNCLGAGFYLTLVRRIKEQPAPVRKEGQCDCTDDCSCK 1232

  Fly   689 -----KLEIND-----FTSREVE-----IMEIIHHFVPTARVLNVVNPTVYICLP-YAYKN-CFA 736
                 |.:.:|     .:.|::|     |..::||.||.||::.|:...:...|| .|:|: .:|
Zfish  1233 CSLCTKFKASDTEKPRVSERQMEGNIESITALVHHHVPEARLIEVIGQELTFLLPSRAFKHRSYA 1297

  Fly   737 QMLYRLETESKELGIHTISMTDTSLEDVFLRCA--GEQDQVDT--------PDGSRNDAPLLAHY 791
            .:...||....::|:.:..::|||||:|||:..  ||...::|        .:|..|.|.:::  
Zfish  1298 SLFRELEETLADMGLSSFGVSDTSLEEVFLKVTADGEAAHINTASDTDRSHANGQSNSANVIS-- 1360

  Fly   792 KRLQDHPPHRGLF---QLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEE 853
            |..:.....:|.|   :.:.|:..|::...:......|..:.:|...||  |.:|..:.:....|
Zfish  1361 KEGRGSQQVKGFFLVVKQFFALLIKRFHHTTRSGKDFLAQIVLPASFVF--ISLMFTLIVPPFGE 1423

  Fly   854 ALPLKLS--------------QMGS------GVIYVHNP-TGHHAHLEQQLRQQIELNGITAK-- 895
            ...|.||              ||.|      |.:.::.| .|....:::.| ::...|.||.:  
Zfish  1424 YPSLTLSPWMYGRQFTFFSNEQMQSPDMRYFGEVLLNRPGFGTRCMVDEPL-EEYPCNNITTEWE 1487

  Fly   896 ----------------------------------TM---------------HLRGSNDVKNESLD 911
                                              ||               .::.:.|:   .:|
Zfish  1488 MPLVNPMLIEMLSNSEWTDISPSPSCQCSTPNKLTMLPVCPEGAGGLPPPQRIQSTGDM---LMD 1549

  Fly   912 LQRDNLADFL-------------------EQVIGIIDMYG------------------------- 932
            |...|::|:|                   ||..|.|.:.|                         
Zfish  1550 LTGRNISDYLVKTYPNLIRTSLKSKYWVNEQRYGGISVGGRLPVLNLDPKSIQNAAAQIGRLLNV 1614

  Fly   933 -GGRGTS-------------DTP-TIEIFYSGNRYHSSVELINLVDSAMLKLGRPE----SEIDT 978
             |||.:.             :|. .::::::...:|:.|..:|:.::|:|:...|.    :|...
Zfish  1615 TGGRYSKLALDEFATFLRYMETENNVKVWFNNKGWHAMVAFMNVANNAILRANLPPGVDLNEYGI 1679

  Fly   979 TYV--PIRRFVSDISPSRLEYYAV--IVPIGMFFFMFY----FISLPFREYANGFKQLQ---TMS 1032
            |.:  |:......:|...:...:|  :|.|.:.|.|.:    |:....:|.....|.||   .:|
Zfish  1680 TAINHPLNLTKEQLSEVTVLTTSVDAVVAINVIFAMSFVPAGFVLYLIQERVTQAKHLQFVSGVS 1744

  Fly  1033 RFTYWFAHFTFDML---ILIFVCVALFSLQSLMMPSELYTT-AELKVIVLSIFFYGCSYLPILYA 1093
            ...||.|:|.:||:   :...:.|.:|    :....:.||: ..|:.::..:..||.|..|::|.
Zfish  1745 PLVYWTANFFWDMINYSVSAAMVVGIF----IAFDKKCYTSPGNLQALIALLMLYGWSVTPMMYP 1805

  Fly  1094 LGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPD-----FNLNHQFRI 1153
            :...|...||  .|:.|..|     .|....|::|       |.|:..|.|     :..|   ::
Zfish  1806 MSYIFNVPST--AYVSLSCI-----NLFIGINSSA-------ITFILDLFDSTEALYKCN---QV 1853

  Fly  1154 INENFITRRHPALIKGLI----SQDTFFAYA----------------------TAVGVMVMAFFT 1192
            :.:..:...|..|.:|||    :|.....||                      .||...|.....
Zfish  1854 LKKALLVFPHFCLGRGLIDMAMNQAVMDVYARFGEDFSLDPFSWDFVGENLTFMAVEGFVYFILN 1918

  Fly  1193 IVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEID-DCAREEKRVTDLIKDPLNDHSLI 1256
            |::::::.       :..|....||         .||::.| |.|:|.:|:   .|...::..|.
Zfish  1919 ILIQYRFF-------LDHWMSDFKK---------PPITDEDVDVAKERERI---YKGGSSNDILQ 1964

  Fly  1257 VHNLRKRYGD--KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIR 1319
            :.:|.|.|..  :.|||.:....:.|||||||||||||||:||:|:..::.:..|...:.|..|.
Zfish  1965 IKDLSKTYTGTFRPAVDRICVGVSPGECFGLLGVNGAGKTTTFKMLTGDIDVTSGEADVAGYSIL 2029

  Fly  1320 EHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTK 1383
            .:.|...:..|||||:||::..:|..:.|:..|.|||:       |.|....|..| ::|:.|::
Zfish  2030 TNILDVHQNMGYCPQFDAIDDLLTGREHLHLYARLRGV-------PESEISRVAEWGIQKLGLSE 2087

  Fly  1384 YQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTS 1448
            |.......||||.||||..|:||||.|||:||||||||:||.||||||..|.......|.|||||
Zfish  2088 YAGCTAGTYSGGNKRKLSTAIAMIGCPALLLLDEPTTGMDPHSRRFLWNSIMSVIQGGRAVVLTS 2152

  Fly  1449 HSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMK-ADTETEMNVSTITGTLKSE 1510
            |||:|||.||.|||||.:|.||||..|..||..  .|:.:.:|:: |......:::.....::|.
Zfish  2153 HSMEECEALCTRLAIMVNGTFKCLGTIQHLKYKFGDGYVVTMKIRAAKVGAVPDLNPAEAFMEST 2217

  Fly  1511 FPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFER 1575
            |||...||.|..||.|.:::       ||:.||.:..|.::....:.||||::.||:.:|:.|  
Zfish  2218 FPGCIQREKHYNTLQYEIAS-------SSLAKIFQVVLANKEMLNIEDYSVSQTTLDQVFVNF-- 2273

  Fly  1576 EAKSQS 1581
             ||.||
Zfish  2274 -AKHQS 2278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 rim_protein <169..1591 CDD:130324 463/1778 (26%)
abca4aNP_001428973.1 None

Return to query results.
Submit another query.