Protein Alignment Eato and Abca12

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_780419.2
• Gene: Abca12 / 74591
• MGIID: 2676312
• Length: 2595
• Species: Mus musculus
• Alignment Length: 1850
• Identity: 465/1850 - (25%)
• Similarity: 788/1850 - (42%)
• Gaps: 378/1850 - (20%)

  Fly     6 TPLF---FVFLRKNLLYLQRNLL-PLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLR- 65
            :|:|   |..|.:.:..||..|. |.:.:...|:..|.|.      .:|.||:..:     |||
Mouse   843 SPIFMNSFHLLNQTIPMLQNTLRNPFVQVFVKFSVGLDAV------ELLKQIDDLD-----VLRL 896

  Fly    66 ELYFPGNELDYI----YYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGS-C 125
            :|.   |.:|.|    ..|.::.|:...         ::.:|::.::...||:...||..:.: .
Mouse   897 KLV---NNIDIIDQLNTLSSLTVNISSC---------VLYDRIQASDTVEEMETVAEQLYKSNEL 949

  Fly   126 FAIDFHRVPNRGS-DRKF---------------RYSLSSNQMRISPRKRF----VNDEEIYHQID 170
            |.....::|:.|| .|.|               |.||.:.|...|.|.:.    .::...::||
Mouse   950 FGSVIFKLPSNGSLHRGFDPEKVSLPPIVRYTIRMSLKTAQTTRSIRTKIWAPGPHNSPSHNQI- 1013

  Fly   171 DDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRLT---YFGTLCSILFN 232
               |.|: |:.||..:::..::.|......||.|..........|..:.||   |...:..::..
Mouse  1014 ---YGRA-FIYLQDSIERAIIELQTGRNSQEVAVQVQAVPYPCFMKDNFLTSVSYSLPIVLMVAW 1074

  Fly   233 VVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF---LIRFVCYTLLMIFVLVVA-----Y 289
            ||.:::||...|.||...|.|::.    |..:|..:.|   ||..:.:.|:.|.:|:|.     .
Mouse  1075 VVFIAAFVKKLVYEKDLRLHEYMK----MMGVNSCSHFFAWLIESIGFLLVTIAILIVILKFGNI 1135

  Fly   290 LYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLAMLIIPYAFSFVRSWATS 353
            |.|..|.|.|.|    |..|..|.::.:||||:.|::. ..|.||.|..:|..:.|..:.:....
Mouse  1136 LPKTNGFILFLY----FSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYVIAFFPFIVLVTVEDE 1196

  Fly   354 LAFV------CFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVF-QSF 411
            |::|      ..|...|.........:..:....::  .::::....:.:|.|.....|:. .||
Mouse  1197 LSYVIKVFMSLLSPTAFSYASQYIARYEEQGVGLQW--ENMYKSPVQDDTTSFGWLCCLILADSF 1259

  Fly   412 LYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHAIIITEL---------- 466
            :|..:..|:..||||..|:..|.:|.:.| :|.|.:..........::.::.|.:
Mouse  1260 IYFFIAWYVRNVFPGTYGMAAPWYFPILP-SYWKERFGCAEVKHEKSNGLMFTNIMMQNTNPSAS 1323

  Fly   467 -----C---KKFQTSKRDTLIS----------------DNLNMTINNKEITVLLGHNGAGKTTMM 507
                 |   ...:...:|..:.                :|||:......||.|||.|||||||.:
Mouse  1324 KTSPDCAFPSNIEPEPKDLQVGVALHGVTKIYGSKTAVENLNLNFYEGHITSLLGPNGAGKTTTI 1388

  Fly   508 NMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGA--CRS 567
            :|:.||....:|.|.|..   :.|:.:.|..:|.|.||.|..||:|..:||..:..::..  .::
Mouse  1389 SMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKT 1453

  Fly   568 DARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELW 632
            ...:.....||..||...|::....|||||||:||:.||:.|.:::|||||||:|:|..|||.:|
Mouse  1454 QLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIW 1518

  Fly   633 DILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRL--------K 689
            |::...:..:.::::||:::|||||.|.|..|..|.|:..|||..||...|.||.|        .
Mouse  1519 DVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPN 1583

  Fly   690 LEINDFTSREVEIMEIIHHFVPTARVL-NVVNPTVYICLPYAYK--NCFAQMLYRLETESKELGI 751
            |:.|.... .|.:..:|...:|.|.:. ::....||:..|::.|  ..:..:|..|:....:|.|
Mouse  1584 LDTNAICD-TVAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNI 1647

  Fly   752 HTISMTDTSLEDVFLRCAGEQDQ---------------------VDTPD----GSRN----DAPL 787
            ....::||::|:|||....:..:                     ..|||    .|.|    |..:
Mouse  1648 GCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKV 1712

  Fly   788 LAHYKRLQDHPPHRG-LFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVEN 851
            |...::|:..    | |.:..||:..|::......|...:..:.:|.|.|..|   |...:|.::
Mouse  1713 LTRSEKLEGF----GLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVATA---MGLGTLRDS 1770

  Fly   852 EEALPLKLSQMGSGVIY-VHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQ-- 913
            ..:.|   ..|.|..|| ....|..:|:.:.      ..:|:.:...:..|.::|...:.|||
Mouse  1771 SNSYP---EIMISPSIYGTSEQTAFYANFDP------STSGLVSALWNFPGIDNVCLNTSDLQCL 1826

  Fly   914 -----------------------RDNLAD-------------FLEQVI----------------- 925
                                   .||:.:             :..|||
Mouse  1827 KKDDLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTGKHMENYLITTAN 1891

  Fly   926 -GIIDMYGGG--------------RGTSDTPTI-EIFYSGNRYHSSVELINLVDSAMLKLGRPES 974
             .:...|||.              ....|..|: :::|....|||....:|.:::.:|::..  |
Mouse  1892 HFVQKRYGGWSFGMKLTNDLRFDVTAVPDNRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNM--S 1954

  Fly   975 EIDTTYVPIRRF------VSDISPSRLEYYAVIVPIGMFFFMFY------FISLPFREYANGFKQ 1027
            |.|.....|..:      |.|...:.:.....|: :.:...|.|      |::...||:....||
Mouse  1955 EYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL-VALSILMGYSVTTASFVTYIVREHQTKAKQ 2018

  Fly  1028 LQTMSRF---TYWFAHFTFDMLI-LIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYL 1088
            ||.:|..   .||..:|.:||:. |:.|..::..:....:|: .|:...|..:.|.:..:|.:..
Mouse  2019 LQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPA-FYSGNNLGAVSLLLLLFGYATF 2082

  Fly  1089 PILYALGNNFKSIS-TISTYLLLMLI--VSAIAPLIT-------SSNAAAMKL-HET-KIAFLCF 1141
            ..:|.|...|.... ...||:.:.|.  :::|..|..       ..|...::| .|| |..||.|
Mouse  2083 SWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIF 2147

  Fly  1142 LPDF-------NLNHQFRII-----------NENFITRRHPALIKGLISQDTFFAYATAVGVMVM 1188
             |.|       .|:.|..::           :|.|...:..|:...|:||.|.|
Mouse  2148 -PQFCFGYGLIELSQQQAVLDFLKAYGVEYPSETFEMDKLGAMFVALVSQGTMF----------- 2200

  Fly  1189 AFFTIVLEHKYLRRRIHDGIWEWAFQR-----KKYNSTGTLPSTPISEIDDCAREEKRVT----- 1243
                      :|.|.:   |.||..::     :|:.|:..:.:  :.|.:|...|..||.
Mouse  2201 ----------FLLRLL---INEWLIKKLRLFFRKFTSSPIMET--VDEDEDVRAERFRVESGAAE 2250

  Fly  1244 -DLIKDPLNDHSLIVHNLRKRY----GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAAN 1303
             ||::         :|.|.|.|    ...:||:.:|.....|||||||||||||||:.|:|:..:
Mouse  2251 FDLVQ---------LHRLTKTYQLIHKKIIAVNNISLGIPAGECFGLLGVNGAGKTTIFKMLTGD 2306

  Fly  1304 LPLDGGTIRIKG-ADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPAS 1367
            :....|.|.|:. :....|...:....|||||.|||:..:|.|:.||:.|.:.|:..:      .
Mouse  2307 IIPSSGNILIRNKSGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEK------D 2365

  Fly  1368 CKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQ 1432
            .|:.|...|.::||..|:.......|.||||||..|:|:||.|:::|||||::|:||.|:|.||:
Mouse  2366 IKDTVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWR 2430

  Fly  1433 CIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTE 1495
            .|.:......:|:||||||:|||.||.|||||.:|:|:|:.::..:|..  .|||:|:.:|   .
Mouse  2431 IISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSRFGRGFTVKVHLK---N 2492

  Fly  1496 TEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYS 1560
            .::::.|:|..::..||...|::.|...|.|.|......|  :::|.:.|.   ::.:..:.::.
Mouse  2493 NKVSMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGV--ANIFDLLET---NKTALNITNFL 2552

  Fly  1561 VNECTLEDIFLKFEREAKSQ---STSRQTS 1587
            |::.|||::|:.|.::.||.   .||.|.|
Mouse  2553 VSQTTLEEVFINFAKDQKSYENVDTSSQGS 2582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	42/149 (28%)
		CcmA	460..767	CDD:224054	107/356 (30%)
		ABC_subfamily_A	461..679	CDD:213230	82/256 (32%)
		ABC2_membrane_3	<937..1117	CDD:289468	43/199 (22%)
		ABC_subfamily_A	1255..1479	CDD:213230	93/228 (41%)
		drrA	1262..1573	CDD:130256	114/317 (36%)
Abca12	NP_780419.2	ABC2_membrane_3	<1006..1267	CDD:289468	63/275 (23%)
		NosY	<1108..1269	CDD:224196	38/166 (23%)
		ZnuC	1346..1570	CDD:224046	81/223 (36%)
		ABC_subfamily_A	1350..1565	CDD:213230	79/214 (37%)
		ABC2_membrane_3	<1913..2174	CDD:289468	57/265 (22%)
		CcmA	2253..2567	CDD:224054	118/336 (35%)
		ABC_subfamily_A	2254..2477	CDD:213230	93/237 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740