Protein Alignment Eato and abca7

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_009304071.2
• Gene: abca7 / 561460
• ZFINID: ZDB-GENE-050517-6
• Length: 2328
• Species: Danio rerio
• Alignment Length: 1853
• Identity: 475/1853 - (25%)
• Similarity: 772/1853 - (41%)
• Gaps: 481/1853 - (25%)

  Fly   108 NNSFEMQLEMEQQCRGSCFAID-----------FHRVPNRGSDRKFRYSL-----SSNQMRISPR 156
            ||:|....|:.:     ||:::           ..|......||:|...:     :|:...:.|.
Zfish   500 NNTFTTLSELTK-----CFSLNKLEGLTTEGEMVERALELLEDRQFWAGIVFLLPNSSSSVLPPH 559

  Fly   157 KRF-----VNDEEIYHQIDDD--------------DYIRSGFLSLQHILDKQYMKYQELGKDFE- 201
            .::     ::|....::|.|.              .|:..||:.:|.::::...:.. .||:.:
Zfish   560 VKYKIRMDIDDVTRTNKIKDKFWDPGPAAEPFSDMRYVWGGFVYVQDLVERAVTRLL-TGKEAKT 623

  Fly   202 -VVVSSMP-----NMEVISMDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKE------- 253
             :.|..||     :...|.:.:..|..|.||..| ::|.::...|   |.||:..|||
Zfish   624 GIYVQQMPYPCFVDDVFIRVLNRSLPLFMTLAWI-YSVAMIIKGV---VYEKEARLKETMRIMGL 684

  Fly   254 ---------FLNLVTPMSFLNGLT-------------------FFLIRFVCYTLLMIFVLVVAYL 290
                     |::...|..|...|.                   |||..|...|:::.|::...:.
Zfish   685 GSGMLWFSWFISSYLPFLFSAALLIAALKWGDILPYSDPAVVFFFLAAFATATIMLCFLISTFFS 749

  Fly   291 YKALGSICFAYV-AVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVRSWATSL 354
            ...|.:.|...: ..|:|.|:|......||.|.  |.:       ||..:.|.||
Zfish   750 RANLAAACGGLIYFTLYLPYVLCVAWREYLTST--HRI-------LASFLSPVAF---------- 795

  Fly   355 AFVCFSTNTFLE-GLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYN 418
            .|.|...:.:.| |:.| |.|:.|....| |....|     |:|.|     :|...:.:||:...
Zfish   796 GFGCEYFSQYEEQGVGI-QWFNLKSSPME-GDTYSF-----NTSIM-----MLYADALIYALATW 848

  Fly   419 YLGCVFPGPGGLKRPMFFFLD-------------PKTYMKRQRNEYTTTPRGTHAII---ITELC 467
            |:..||||..|:.||.:|...             |.....|:..:.......|:.|:   |..|.
Zfish   849 YIEAVFPGQYGIPRPWYFIFQLNYWGGVPLELGLPIPPAPREEQDARIEAEPTNLILGVSIRNLV 913

  Fly   468 KKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIV-----CSER 527
            |.::  |...|..::||:.....:||..||||||||||.|:::.||.|..:|.|.|     .|:.
Zfish   914 KIYK--KGAKLAVNHLNIKFYEGQITSFLGHNGAGKTTTMSILTGLFPPTAGTIYVKGMDIRSDM 976

  Fly   528 DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKN 592
            |:  .|..:|.||||:|....:|..:|:.|:.:::|....:.....:..|:.:||..||.|..||
Zfish   977 DI--IRRTLGVCPQHNVLFDILTVEEHVWFYGRMKGMSLEEVNKEMNSLLEDVGLQHKRFEQTKN 1039

  Fly   593 LSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVL 657
            |||||:|:||:.||..|.:|:|:||||::|:|..|||.:||:||..|:.:.::::||||:||::|
Zfish  1040 LSGGMQRKLSVAIAFIGGSKVVVLDEPTAGVDPYSRRGIWDLLLKYREGRTIILSTHYMDEADLL 1104

  Fly   658 GDTICILANGKLQSIGSPLELKRKSGIGYRLKL----------------------------EIND 694
            ||.|.|::.|||...|:||.||.:.|.||.|.|                            .::|
Zfish  1105 GDRIAIISQGKLCCCGTPLFLKARLGTGYYLTLVKREMHRTPSNTSSGKIPSAASPKDSDSSVSD 1169

  Fly   695 FTSREVE--------IMEIIHHFVPTARVLNVVNPTVYICLPYAYK--NCFAQMLYRLETESKEL 749
            .|....|        :|.:...:||.|:::..:.....|.||.|..  ...|..|..|:....|.
Zfish  1170 DTGLGSEENGFDVAALMALAQQYVPDAQLVEDIGREAVINLPNAASEDGTLALFLNELDKRQGEF 1234

  Fly   750 GIHTISMTDTSLEDVFLRCAGE-------------QDQVDTPDGSRNDAPLLAHYKRLQ------ 795
            |:.:..::||:||::|||.|.|             |:....|...|:.|...:..|..|
Zfish  1235 GVVSYGLSDTTLEEIFLRVAEETGVDADPEDPPVSQEPQGAPSEDRDAARKRSIRKEAQETDPLS 1299

  Fly   796 -----DHPPHRGLF---QLWMAVFYK--KWTFISNEWLYTLIMLCIPFVCV----------FGAI 840
                 |..|..|.|   |...|:|.|  |:.|.|...::..|:|...||.:          ||..
Zfish  1300 GDGQSDSAPLTGCFHTCQQLRALFTKRLKYAFRSRRGIFAQIVLPAVFVLIALLFSLIVPPFGKY 1364

  Fly   841 LVMHAMSLVENEE---------------------------------------------------A 854
            ..:.....:..|:                                                   .
Zfish  1365 PSLELQPWMYGEQFTFFSNDAPQDPAMQNLLKALLDPPGFGTKCMQPNGDTECLAKAETKFVRPQ 1429

  Fly   855 LPLKLSQM-------------------------------GSGVI-----------YVHNPTGHHA 877
            :|..:.|:                               |:|.:           .:.|.||.:.
Zfish  1430 IPYSMWQLFHNGNFSIEKPSPECECSTEKIRRMLPECPEGAGGVPPPQMQQITGDILQNLTGRNI 1494

  Fly   878 H----------LEQQLRQQ----------IELNGITAKTM----HLRGS--------NDVKNESL 910
            .          |::.|:.:          ..|...::.||    ||..|        |..:|.||
Zfish  1495 SDYLIKTYPQILKKSLKTKKWVNEFRYGGFSLGAKSSLTMSEPHHLEESVLAIRRRYNIAENGSL 1559

  Fly   911 DLQRDNLADFLEQVIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESE 975
            |.....|.|.|.             |.:....::::::...:|:....:|::::.:|:...|...
Zfish  1560 DQLLQRLPDVLS-------------GLTSQNNVKVWFNNKGWHAMASFVNIMNNGLLRANLPPKT 1611

  Fly   976 IDTTY-VPIRRFVSDISPSRLEYYA-------VIVPIGMFFFMFY----FISLPFREYANGFKQL 1028
            ....| :.......:::..:|...|       |:|.|.:.|.|.:    |:.....|..:..|.|
Zfish  1612 ERRKYGITAYNHPLNLTKEQLTEMALMTTSVDVLVSICVIFAMSFVPASFVLFLIEERVSKSKHL 1676

  Fly  1029 QTMS---RFTYWFAHFTFDML-------ILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFY 1083
            |.:|   ...||..::.:||:       :::|:.:: |..:|.:      :...|..:||.:..|
Zfish  1677 QFVSGVKPILYWTTNYVWDMVNYTVPATMVVFIFIS-FQQESYV------SEKNLPALVLLLLLY 1734

  Fly  1084 GCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLN 1148
            |.|..|::|.....|...||  .|::|    ::|...|..:.:.|..:.|..:       |.:||
Zfish  1735 GWSITPLMYPASFIFSVPST--AYVVL----TSINLFIGINGSVATFVLELFV-------DEHLN 1786

  Fly  1149 HQFRIINENFITRRHPALIKGLISQ-------DTF---------------FA----YATAVGVMV 1187
            ...||:.:.|:...|..|.:|||..       |.|               |.    :|.|:..:|
Zfish  1787 EVNRILKKVFLIFPHFCLGRGLIDMAKNQAMADAFQRLGTKQNLDPLSWDFVGKNLFAMAMEGIV 1851

  Fly  1188 MAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPIS-EIDDCAREEKRVTDLIKDPLN 1251
            ...||::|::|:.   ::...|          |...||  |:. |.:|.|||.:||.:  ...|.
Zfish  1852 FFLFTVLLQYKFF---VNFSRW----------SGFVLP--PLGMEDEDVARERERVKN--GRALG 1899

  Fly  1252 DHSLIVHNLRKRY--GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIK 1314
            | .||:.:|.|.|  |.|.||:.:.....:||||||||||||||||||:|:..:..:..|...:.
Zfish  1900 D-ILILSDLSKVYKAGRKPAVNRLCLGIPRGECFGLLGVNGAGKTSTFRMLTGDTRITYGEAFLS 1963

  Fly  1315 GADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEK 1378
            ...:.....|..:..|||||:||:...:|..:.|.:.|.|||:       |.|..|.|..| ::|
Zfish  1964 NQSVLTEMEKVHQLMGYCPQFDAIIDLLTGREHLEFYARLRGV-------PESYVEKVAQWGVQK 2021

  Fly  1379 MHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRT 1443
            :.|::|...:...||||.||||..|:|:|||..::.|||||||:||.::||||.||.....:.|:
Zfish  2022 LGLSQYADREAGGYSGGNKRKLSTAIALIGAAPVIFLDEPTTGMDPKAKRFLWNCILSVVKEGRS 2086

  Fly  1444 VVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGT 1506
            ||||||||:|||.||.|:|||.:|:|:||.::..||..  .|:||.|::...:.....|...
Zfish  2087 VVLTSHSMEECEALCTRMAIMVNGRFQCLGSVQHLKNRFGDGYTIILRLSTPSAEPCPVDAY--- 2148

  Fly  1507 LKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAE---EYLGDRLSALVADYSVNECTLED 1568
            :::.|||::|:|.|...|.|.:.:|...:  :.||::..   |.||      :|||||::.||:.
Zfish  2149 IQNAFPGIQLKERHQNVLQYQLPSQTCSL--ARVFEVLSNNYEELG------IADYSVSQTTLDQ 2205

  Fly  1569 IFLKFEREAKSQSTSRQTSVQ--------RRPE 1593
            :|:.|.::.......|:.::.        .||:
Zfish  2206 VFVNFAKDQTDDDQLREITINGGSVALQPNRPQ 2238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	39/173 (23%)
		CcmA	460..767	CDD:224054	120/352 (34%)
		ABC_subfamily_A	461..679	CDD:213230	92/225 (41%)
		ABC2_membrane_3	<937..1117	CDD:289468	38/201 (19%)
		ABC_subfamily_A	1255..1479	CDD:213230	101/226 (45%)
		drrA	1262..1573	CDD:130256	127/318 (40%)
abca7	XP_009304071.2	AAA	1..2220	CDD:333001	472/1833 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820