DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and abca4

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001011033.1	Gene:	abca4 / 496442	XenbaseID:	XB-GENE-1000810	Length:	2359	Species:	Xenopus tropicalis

Alignment Length:	1814	Identity:	458/1814 - (25%)
Similarity:	755/1814 - (41%)	Gaps:	464/1814 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 IDDDDYIRSGFLSLQHILDKQYMKYQELGK-DFEVVVSSMPNM----EVISMDSHRLTYFGTLCS 228
            ::|..||..||..||.::|...:|.|...: ...:.:..||..    :|..:..:|       |.
Frog   598 VEDMRYIWGGFAYLQDMIDHGIIKSQTSTEVPAGIYLQQMPYPCFVDDVFMITLNR-------CF 655

  Fly   229 ILFNVVL----LSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYT----LLMIFVL 285
            .:|.|:.    :|..|...|.||:..|||.:..:...:.:..||.|:..|...|    ||.:.::
Frog   656 PIFMVLAWIYSISMLVKDIVLEKELRLKETMKNMGVTNDVIWLTRFIDSFTVMTTSTILLTVVIV 720

  Fly   286 VVAYLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLA--MLIIPYAFSFV 347
            |...|:.:...|.|.::    :.:.::|:..|:|:|:.|... ..|...|:.  .|.:|:...|
Frog   721 VGGVLHYSNPIILFCFL----MAFTIATIMQAFLMSVFFSKANLAAACSGVIYFTLYLPHILCF- 780

  Fly   348 RSWATSLAFVCFSTNTFLE------GLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVL 406
             :|...:.....:..:||.      |.:....:..:....::|.:....:.....|.:||::::|
Frog   781 -AWQDRMTIKLKTLASFLSPVAFGFGTEYLSRYEEQGLGLQWGNIRKSPMEGDEYSFLFSIFMML 844

  Fly   407 VFQSFLYAMLYNYLGCVFPGPGGLKRPMFF----------------------------------F 437
            : .:|:|..|..|:..||||..|:.:|.:|                                  .
Frog   845 L-DAFIYWTLAWYIDHVFPGEYGIPKPWYFPFLATYWCKFEHEFGGDADSIETELSIHEHIEENH 908

  Fly   438 LDP-------------------------------------------------KTYMKRQRNE--- 450
            ::|                                                 |...:::||:
Frog   909 IEPTDNQPEALPDGVKEEAEKSVKQDDIIVNKDSSACKHKVKKEKEQEEKQRKDEQEKERNDKDD 973

  Fly   451 ------------YTTTPRG-THAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAG 502
                        :...|.| ...:.|.:|.|.::.:.:..:  |.:|:|....:||..|||||||
Frog   974 MKDGFTYIGNPFFEPEPPGMVPGVYIQDLVKVYENTYKPAV--DRMNITFYEGQITAFLGHNGAG 1036

  Fly   503 KTTMMNMIMGLVPKDSGKIIVCSERDVA----SYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRG 563
            |||.:::|.||.|..||.:.| ..||:.    |.|..:|.||||::...::|..:|:.|:|||:|
Frog  1037 KTTTLSIITGLFPPTSGTVWV-RGRDIQTHMDSIRQSLGMCPQHNILFRHLTVEEHILFYAQLKG 1100

  Fly   564 ACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSR 628
            ..|..|...|:..|:.:|:..|||:..:||||||:|:||:.:|..|.:|:|:||||:||:|..||
Frog  1101 KSRKQAERQAEVMLEDMGIPHKRNDEAQNLSGGMQRKLSVALAFVGESKVVVLDEPTSGVDPYSR 1165

  Fly   629 RELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL--- 690
            |.:||:||..|..:.::::||:|:||::|||.|.|::.|||...||||.||...|.|:.|.|
Frog  1166 RSIWDLLLKYRSGRTIILSTHHMDEADLLGDRIAIVSQGKLFCSGSPLFLKNCFGTGFYLTLVRR 1230

  Fly   691 --EIND---------------------------FTSREVE-----IMEIIHHFVPTARVLNVVNP 721
              .|.|                           ...:|::     :.|:|||.||.|::|..:..
Frog  1231 MRNIKDTGKKDSASCQSDCSCPCSSCTPKVKENLLEQELDGDVSGLTELIHHHVPEAKLLESIGQ 1295

  Fly   722 TVYICLP---YAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQ-DQVDTPD--- 779
            .:...||   :.:: .:|.:...||....:||:.:..::||.||::||:...:. ...:||:
Frog  1296 ELIYLLPSKDFKFR-AYASLFRELEETLGDLGLSSFGISDTPLEEIFLKVTADSVTGTETPEEWM 1359

  Fly   780 ----------GSRNDAPLL--------------AHYKRLQDHPPH--------RG---------L 803
                      |..|...::              :|:.:.:.:||:        ||         |
Frog  1360 LQQRKSRTSLGVDNQTTVINIDNKGQESSIRKDSHHCKAEKNPPNINDREADGRGSRQIKGTELL 1424

  Fly   804 FQLWMAVFYKKWTFI--SNEWLYTLIMLCIPFVCV----------FGAI--LVMH------AMSL 848
            .|.:.|:..|::...  |::..:..|:|...||.:          ||..  |.:|      ....
Frog  1425 QQQFNALIIKRFKHATRSHKDFFAQIVLPASFVLLALVFTLIVPPFGEYPSLTLHPWIYGQQFVF 1489

  Fly   849 VENEEALPLKLSQMGSGVIYVHNP-TGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESL-- 910
            ..||:....:::...:.  ::::| .|.....:|.|.::.:....:.:......|..|.|..|
Frog  1490 FSNEQPGNEQMATFSNA--FLNSPGLGTRCMKDQPLSKKYQCTNTSNEWTMPAVSPSVTNMLLSQ 1552

  Fly   911 ----------------------------------------------DLQRDNLADFL-------- 921
                                                          ||...|::|||
Frog  1553 EWTRDNPSPSCTCSSRSKLMMLPECPEGAGGRPPPQRIQPSSEIIQDLTERNISDFLLKTYPDLI 1617

  Fly   922 -----------EQVIGIIDMYG--------GG-------------RGTSDTPT------------ 942
                       ||..|.|.:.|        ||             ..|:.|.|
Frog  1618 RSSMKSKYWVNEQRYGGISVGGKLPVLHVKGGDIVSFFSQVGQMTNVTAGTTTKAISQELQTFLQ 1682

  Fly   943 -------IEIFYSGNRYHSSVELINLVDSAMLK--LGR---PES-EIDTTYVPIRRFVSDISPSR 994
                   |:::::...:||.|..||:.::|:|:  ||.   ||. .|.|...|:......:|...
Frog  1683 NLETEDNIKVWFNNKGWHSMVIFINVANNAILRANLGADKDPEEFGITTMNHPLNLTKDQLSEVT 1747

  Fly   995 L--EYYAVIVPIGMFFFMFY----FISLPFREYANGFKQLQTMSRFT---YWFAHFTFDMLILIF 1050
            :  ....|:|.|.:.|.|.:    |:....:|..:..|.||.:|..|   ||..:|.:| :|...
Frog  1748 VLTTSVDVVVAICVIFAMSFIPASFVLYLIQERVSNAKHLQFVSGVTPAIYWLTNFAWD-IINYA 1811

  Fly  1051 VCVALFSLQSLMMPSELYT-TAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLI- 1113
            :.||:..:..:....:.|| ::.|..::..:||||.:.:|::|.....|...||  .|:.|..|
Frog  1812 ISVAMVVIIFIAFDKKAYTSSSNLPALIALLFFYGWAVIPMMYPASYLFNVPST--AYVALSCIN 1874

  Fly  1114 ------VSAIAPLIT--SSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGL 1170
                  .|||..::.  .:|.:.:|.:|.....|...|.|.|..               .||...
Frog  1875 LFIGINSSAITFILDLFENNRSLLKFNEKLKDLLLIFPHFCLGR---------------GLIDLA 1924

  Fly  1171 ISQDTFFAYAT--------------------AVGVMVMAFFT--IVLEHKYLRRRIHDGIWEWAF 1213
            ::|.....||.                    |:.|..:.:||  ::::|::.       ...|..
Frog  1925 MNQAVTDVYARFGEEHVSNPFQWEFLGRNIFAMAVEGVVYFTLNLLIQHRFF-------FSTWFS 1982

  Fly  1214 QRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDKL--AVDGVSFA 1276
            :..|....|        |.:|.|:|.:||   ||....:..|.:..|.|.|..|.  |||.:...
Frog  1983 EPPKGLVEG--------EDEDVAQERQRV---IKGGGKNDILKLKELTKTYPGKQSPAVDRLCVG 2036

  Fly  1277 AAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKF 1341
            ...|||||||||||||||:||:|:..::.:..|...:.|..|.:......:..|||||:||::..
Frog  2037 VRPGECFGLLGVNGAGKTTTFKMLTGDIQVTSGDASVAGYSILQDIADVHQNSGYCPQFDAIDDL 2101

  Fly  1342 MTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRHYSGGTKRKLLAAMA 1405
            :|..:.|.....|||:.....|..|.       | :||:.|.||.......||||.||||..|:|
Frog  2102 LTGREHLQLYGRLRGVPEDEIDMVAD-------WGIEKLGLGKYADNLTGTYSGGNKRKLSTAIA 2159

  Fly  1406 MIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFK 1470
            :||.|.:|||||||||:||.||||||..|.....:.|.||||||||:|||.||.|||||..|.||
Frog  2160 LIGCPPVVLLDEPTTGMDPQSRRFLWNSIVSIIKEGRAVVLTSHSMEECEVLCTRLAIMVKGTFK 2224

  Fly  1471 CLNNICALKRL--SGFTIKLKMKADTE-TEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQE 1532
            ||..|..||..  .|:.:.:|::|... ...:...:...:::.|||...||.|...|.|.:|:
Frog  2225 CLGTIQHLKYKFGDGYIVTMKVRASKPGLAPDPGPVEKFIQTNFPGSVQREKHYNMLQYQLSS-- 2287

  Fly  1533 SVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTSRQTSVQRR 1591
                 ||:.::.:..:.::.|..:.:|||::.||:.:|:.|   ||.|:......:..|
Frog  2288 -----SSLARVFQLLISNKDSLNIEEYSVSQTTLDQVFVNF---AKQQTEDEDIHLHPR 2338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	33/152 (22%)
		CcmA	460..767	CDD:224054	123/350 (35%)
		ABC_subfamily_A	461..679	CDD:213230	94/221 (43%)
		ABC2_membrane_3	<937..1117	CDD:289468	54/221 (24%)
		ABC_subfamily_A	1255..1479	CDD:213230	105/226 (46%)
		drrA	1262..1573	CDD:130256	126/316 (40%)
abca4	NP_001011033.1	rim_protein	1..2347	CDD:130324	458/1814 (25%)
		ABC2_membrane	604..>778	CDD:304374	43/184 (23%)
		ABC_subfamily_A	997..1216	CDD:213230	94/221 (43%)
		ABC_subfamily_A	2013..2233	CDD:213230	105/226 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930