DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and CG33970

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001034071.1	Gene:	CG33970 / 43186	FlyBaseID:	FBgn0053970	Length:	777	Species:	Drosophila melanogaster

Alignment Length:	881	Identity:	191/881 - (21%)
Similarity:	325/881 - (36%)	Gaps:	255/881 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 RPMFFFLDPKTYMKRQRNEYTTTPRGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLL 496
            |...|...|.|...|::          .|:.:....|.:.:||...::.|.||||:....|..||
  Fly    29 RRRLFISQPSTLATRRQ----------QAVCVRRAHKMYGSSKNPNVVLDGLNMTVPKGSIYGLL 83

  Fly   497 GHNGAGKTTMMNMIMGLVPKDSGKIIVCSER------DVASYRHLIGFCPQHSVFMSYMTCHQHL 555
            |.:|.||||:::.|:|....:||:|.|...|      .|...|  ||:.||........|..:.|
  Fly    84 GASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPR--IGYMPQEIALYGEFTMRETL 146

  Fly   556 EFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPS 620
            .:|..:....:.|..|..:..||.|.|.: .::|.||||||.:||:||.:|:....:::|||||:
  Fly   147 IYFGIISAMSKGDIEDRTEFLLKLLNLPN-ASKFVKNLSGGQQRRVSLAVALLHEPELLILDEPT 210

  Fly   621 SGLDINSRRELWDILLNLRK--EKAVLVTTHYMEE---AEVLGDTICILANGKLQSIGSPLELKR 680
            .|:|...|:.:||.|:::.|  ...|::||||::|   |.::|    :|..||:.:..||..|::
  Fly   211 VGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDECAQAHMIG----LLRGGKMLAEESPDYLRQ 271

  Fly   681 KSGIGYR--------LKLEI--NDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCF 735
            :    |.        |||.:  |....|...|.:.|   |....|..:.||    .|..:.:...
  Fly   272 Q----YNADSLEDVFLKLSVLQNMGKRRRSSIAQEI---VEQVTVPAISNP----ALDMSDEQHA 325

  Fly   736 AQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVDT------PDGSRNDAPLLAHYKR- 793
            |::       |.|.| ..|||:..:           :|.:.|      |.....:.|....|..
  Fly   326 AEI-------SGEFG-DNISMSSAA-----------RDPISTTAPAAPPLPPPQEIPTSFWYNLH 371

  Fly   794 -LQDHPPHRGLFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPL 857
             :|.|..|        |:.:|.:.::.......|.::.:|.|.:   :|..:|:.
  Fly   372 VMQSHHLH--------ALIWKNFLWMMRNVGVMLFIVGLPVVQI---LLFCYAIG---------- 415

  Fly   858 KLSQMGSGVIYVHNPTG-------HHAHLEQQLRQQIELNGITAKTMHLRGSND--VKNESLDLQ 913
                        |:|||       |....|..:.|...::....:||......|  |||:|:.:|
  Fly   416 ------------HDPTGLKLAVANHEMSGEMIMEQFCPVHTGCNQTMLSCRYLDMLVKNKSMVVQ 468

  Fly   914 ---RDNLADFLEQV----------------IGIIDMYGGGR----GTSDTPTI------------ 943
               .|.:|  .|:|                ..:::....||    ||.::..:
  Fly   469 YVTDDEMA--YEEVRKGRAWAALVIQPNYTASLMERVEDGRYAEDGTIESSDLAVRMDWSNQQIS 531

  Fly   944 EIFYSGNRYHSSVELINLVDSAML------KLGRPESEIDTTYVPIRRFVSDISPSRLEYYAVIV 1002
            ::.|...:|    ...|.|...:.      ||||         ||: .|...:...|...:....
  Fly   532 QLLYRDLQY----TFFNFVGDMLSDCDVNPKLGR---------VPV-DFQHPVYGYRNPNFTDFA 582

  Fly  1003 PIGMFFFMFYFISLPFREYA------NGFKQ--------------LQTMSRFTYWFAHFTFDMLI 1047
            ..|:...:.:|:::.....|      .|..:              .|.:::||...:..||.:::
  Fly   583 APGVILTIIFFLAVAVTSGAMLIDRNEGMLERCLVAGITGPEILLSQVVTQFTVMLSQTTFVLIV 647

  Fly  1048 L-----------IFVCVALFSLQSL-------MMPSELYTTAELKVIVLSIFFYGCSYLPILYAL 1094
            .           |::.|||..|..|       ::...:.|......:.:.      |:|||:...
  Fly   648 SFYFFELTLVGNIWLVVALCILNGLCGMSFGFVISCAVDTERTATYVAMG------SFLPIVMLC 706

  Fly  1095 GNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINENFI 1159
            |              ::..:..:.||:.              .|..|||........|.|.:...
  Fly   707 G--------------IIWPIEGMFPLLQ--------------FFTAFLPLTKPTESMRSILQRGW 743

  Fly  1160 TRRHPALIKGLISQDTFFAYATAVGVMVMAFFTIVL 1195
            ...:|.:..|.||..::        |:|....||:|
  Fly   744 GIDNPVVYNGFISISSW--------VLVFLVLTILL 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468
		CcmA	460..767	CDD:224054	98/327 (30%)
		ABC_subfamily_A	461..679	CDD:213230	76/228 (33%)
		ABC2_membrane_3	<937..1117	CDD:289468	34/235 (14%)
		ABC_subfamily_A	1255..1479	CDD:213230
		drrA	1262..1573	CDD:130256
CG33970	NP_001034071.1	P-loop_NTPase	48..270	CDD:304359	76/228 (33%)
		CcmA	54..321	CDD:224054	90/284 (32%)
		ABC2_membrane_3	394..770	CDD:289468	76/458 (17%)
		ABC2_membrane	<581..738	CDD:279410	28/190 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46598
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810