DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca17

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001026792.2	Gene:	Abca17 / 381072	MGIID:	3625331	Length:	1733	Species:	Mus musculus

Alignment Length:	1773	Identity:	489/1773 - (27%)
Similarity:	800/1773 - (45%)	Gaps:	296/1773 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FFVFLRKNLLYLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPGNE 73
            |.:..||.|:.|...|:| ||.|:     :..||..:..|.......:.|. ::.|..:||
Mouse    15 FILKRRKTLITLLEMLMP-LLFCA-----IVLYLRLNSMPRKKSSTNYPAV-DVSLLPVYF---- 68

  Fly    74 LDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCFAIDFH-----RV 133
                |..|:..         :..|..||.:    :.:.:...|:.:|    .||:||.     .|
Mouse    69 ----YNYPLKS---------KFQLAYIPSK----SETLKAVTEVVEQ----TFAVDFEVLGFPSV 112

  Fly   134 PNRG----SDRKFRYSL----------SSNQ---------MR--------ISPRKRFVNDEEI-- 165
            |...    .|.|..|.|          |||:         :|        :||.:.....|||
Mouse   113 PLFEDYIIKDPKSFYILVGIIFHHDFNSSNEPLPLVVKYDLRFSYVQRNFVSPPRHLFFQEEIEG 177

  Fly   166 -------------------YHQIDDDDYIRSGFLSLQHILDKQYMKYQ------ELGKDFEVVVS 205
                               |....:..|.:.|||::||.:||..|::.      .:.||..|:|.
Mouse   178 WCTAFLYPPNLSQAPREFSYADGGNPGYNKEGFLAIQHAVDKAIMRHHAPKAALNMFKDLHVLVQ 242

  Fly   206 SMPNMEVISMDSHRLTYFGTLCSILFNVVLLSSFVV-------PFVEEKQNGLKEFLNLVTPMSF 263
            ..|      ...|....|..:....|.::|:.||:.       ..:.||:...||:::::...|:
Mouse   243 RFP------FGPHIQDPFLVILQNEFPLLLMLSFICVELIITNSVLSEKERKQKEYMSMMGVESW 301

  Fly   264 LNGLTFFLIRFVCYTLLMIFVLVVAYLYKALGSICF-----AYVAVLFLLYILSTMSYAYLISIC 323
            |:.:.:|:..|:..: :.:.|:.|.:..|......|     ..:.:..:.:.::|:.:|:::|..
Mouse   302 LHWVAWFITFFISVS-ITVSVMTVLFCTKINRVAVFRNSNPTLIFIFLMCFAIATIFFAFMMSTF 365

  Fly   324 FHSVFYAK-IGGLAMLI--IPY---AFSFVRSWATSLAFVCFSTN----TFLEGLDIFQTFSNKR 378
            |....... |||.....  :||   .||:.:...|.....|..:|    |.:..:.:|:......
Mouse   366 FQRAHVGTVIGGTVFFFTYLPYMYITFSYHQRTYTQKILSCLFSNVAMATGVRFISLFEAEGTGI 430

  Fly   379 KNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFL----- 438
            :.|..|:|       ....:...|..:|:..||||.::...:..:||...|:.:..:.|.
Mouse   431 QWRNIGSV-------WGDFSFAQVLGMLLLDSFLYCLIAFLVESLFPRKFGIPKSWYIFAKKPVP 488

  Fly   439 ---------DPK-----TYMKRQRNEYTTTPRGTHAIIITELCKKFQT--SKRDTLISDNLNMTI 487
                     ||:     .:|:.:......|      |.|..|.|.|.:  ||| |.|.| |:|.:
Mouse   489 EIPPLLNIGDPEKPSKGNFMQDEPTNQMNT------IEIQHLYKVFYSGRSKR-TAIRD-LSMNL 545

  Fly   488 NNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIV--CS-ERDVASYRHLIGFCPQHSVFMSYM 549
            ...::|||||||||||||:.:::.||:....|...:  |. .:|:...|..:|:||||.:.....
Mouse   546 YKGQVTVLLGHNGAGKTTVCSVLTGLITPSKGHAYIHGCEISKDMVQIRKSLGWCPQHDILFDNF 610

  Fly   550 TCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIV 614
            |...||.|:.||:|....|..:...|.|..|||.||.|...|.|||||||:||:|||:...:|::
Mouse   611 TVTDHLYFYGQLKGLSPQDCHEQTQEMLHLLGLKDKWNSRSKFLSGGMKRKLSIGIALIAGSKVL 675

  Fly   615 ILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELK 679
            |||||:||||..|||.:||:|...:.::.||:|||:|:||::|||.|.|||.|:||..|||..||
Mouse   676 ILDEPTSGLDSPSRRAIWDLLQQQKGDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSPSFLK 740

  Fly   680 RKSGIGYR---LKLEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYR 741
            :|.|.||.   :|..:.| ||:   :.|:|:|.:|.|.:.:.:...:.:.||....:.|..:...
Mouse   741 QKYGAGYYMTIIKTPLCD-TSK---LSEVIYHHIPNAVLESNIGEEMIVTLPKKTIHRFEALFND 801

  Fly   742 LETESKELGIHTISMTDTSLEDVFLR-CAGEQDQVDTPDGSRNDA-PLLAHYKRLQDHPP--HRG 802
            ||....||||.|.:.:.|::|:||:| |.......:.....|:.. ||..|::...|...  |.|
Mouse   802 LELRQTELGISTFATSVTTMEEVFIRVCKLADPSTNVLTEKRHSLHPLPRHHRVPVDRIKCLHSG 866

  Fly   803 LF------------------QLWMAVFYKKWTFISNEWLYTL-IMLCIPFVCVFGAILVMH-AMS 847
            .|                  |.:.|:..||.|:....|:..| :.:.:|...:..::...: .:.
Mouse   867 TFPVSTEQPMRLNTGFCLLCQQFYAMLLKKITYSRRNWMLVLSVQVLLPLAIIMLSLTFFNFKLR 931

  Fly   848 LVENEEALPLKLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDL 912
            .::|   :||:|:....|...|......::||:.||........:.|..:.||....|:
Mouse   932 KLDN---VPLELTLQTYGQTIVPFFIAENSHLDPQLSDDFVKMLVAAGQVPLRIQGSVE------ 987

  Fly   913 QRDNLADFL-----EQVIGIIDMYGGGRGTSDT---PTIEIFYSGNRYHSSVELINLVDSAMLK- 968
                  |||     |...|...:|.......|.   .|::..::...|||....:.|||:.:.|
Mouse   988 ------DFLLKKAKEAPEGFDKLYVVAASFEDVNNHTTVKALFNNQAYHSPSLALTLVDNLLFKL 1046

  Fly   969 LGRPESEIDTTYVPIRRFVSDISPSRL-----EYYAVIVPIGMFFFMFYFISLPFREYANGFKQL 1028
            |....:.|.||..|..:...::|.|.|     .:|.|:    .|.|...|:|..|.....|.|.:
Mouse  1047 LSGANASITTTNYPQPQTAIEVSESILYQGPKGHYLVV----NFLFGIAFLSSSFSILTVGEKSV 1107

  Fly  1029 QT--------MSRFTYWFAHFTFDMLILIFVCVALFSLQSLMMPSELYTTAE-LKVIVLSIFFYG 1084
            ::        :|...:|.:...:| ||...|...|..|..|....|.:...| :..:||.:..||
Mouse  1108 KSKSLQFVSGVSTAVFWLSALLWD-LISFLVPTLLLVLVFLWYKEEAFAHHESIPAVVLIMMLYG 1171

  Fly  1085 CSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIA------FLCFLP 1143
            .:.:|::|.:..:|.:..:....|::||...:|:|::..:..:...|..|:::      || .||
Mouse  1172 WAVIPLVYTVSFSFNTPGSACVKLVVMLTFLSISPVVLVTVTSEKDLGYTELSDSLDHIFL-ILP 1235

  Fly  1144 DF-------NLNHQFRIINENFITRRHPA------LIKGLISQDTFFA--------YATAVGVM- 1186
            ..       ||.:.|.:  :.|.:.::.:      :::|.:.|:..:|        |.||:.|:
Mouse  1236 GHCLGMALSNLYYNFEL--KKFCSAKNLSDIDCNDVLEGYVVQENIYAWESLGIGKYLTALAVLG 1298

  Fly  1187 ----VMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIK 1247
                .|.|.|.......|:.|: .|.:. :|.::|   :|.:......|.:|...|.:.:...::
Mouse  1299 PVYITMLFLTEANAFYVLKSRL-SGFFP-SFWKEK---SGMIFDVAEPEDEDVLEEAETIKRYLE 1358

  Fly  1248 DPLNDHSLIVHNLRKRYGDK---LAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGG 1309
            ..:..:.|:|..:.|.|.||   |||:.|||...:.|||||||:|||||||.|.|:.:..|:..|
Mouse  1359 TLVKKNPLVVKEVSKVYKDKVPLLAVNKVSFVVKEEECFGLLGLNGAGKTSIFNMLTSEQPITSG 1423

  Fly  1310 TIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKY 1374
            ...:||.:|:....|.|::.||||::|||..|||..:.|...|.:||:..      ...|..|..
Mouse  1424 DAFVKGFNIKSDIAKVRQWIGYCPEFDALLNFMTGREMLVMYARIRGIPE------CHIKACVDL 1482

  Fly  1375 WLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQG 1439
            .||.:.:.......|:.||||.||.|...:|::|.||::|||||:||:||::||.||..::..:.
Mouse  1483 ILENLLMCVCADKLVKTYSGGNKRMLSTGIALVGEPAVILLDEPSTGMDPVARRLLWDTVERVRE 1547

  Fly  1440 KDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSG--FTIKLKMKADTETEMNVST 1502
            ..:|:|:|||||:|||.||.|||||..|:||||.:...||...|  ::::.|::...:.:| :..
Mouse  1548 SGKTIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGISYSLQAKVRRKWQQQM-LEE 1611

  Fly  1503 ITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLE 1567
            ....:...|||..|.:.|...|.|::....  :.|:.||.|.|:...|   .::.|||:::.:||
Mouse  1612 FKAFVDLTFPGSNLEDEHQNMLQYYLPGPN--LSWAKVFSIMEQAKKD---YMLEDYSISQLSLE 1671

  Fly  1568 DIFLKFEREAKSQSTSRQ 1585
            ||||.|.|  ...||..|
Mouse  1672 DIFLNFTR--PESSTKEQ 1687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	29/155 (19%)
		CcmA	460..767	CDD:224054	132/314 (42%)
		ABC_subfamily_A	461..679	CDD:213230	103/222 (46%)
		ABC2_membrane_3	<937..1117	CDD:289468	47/197 (24%)
		ABC_subfamily_A	1255..1479	CDD:213230	100/226 (44%)
		drrA	1262..1573	CDD:130256	125/315 (40%)
Abca17	NP_001026792.2	rim_protein	<209..1684	CDD:130324	441/1542 (29%)
Abca17	NP_001026792.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1681..1733		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760