DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and CG8908

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_611464.3	Gene:	CG8908 / 37293	FlyBaseID:	FBgn0034493	Length:	1626	Species:	Drosophila melanogaster

Alignment Length:	1785	Identity:	426/1785 - (23%)
Similarity:	737/1785 - (41%)	Gaps:	393/1785 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFFVFLRKNLLYLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPGN 72
            |.::.:.|...:...|.|..::|   ..|.:..:|.::...:..     |.:.|..::  |.|.|
  Fly    16 LLWLVICKTARFQFSNTLTSVII---IVGPIVVFLVYAATALFR-----EPQEETSVK--YPPVN 70

  Fly    73 ---ELDYIYYSP----ISPNVEDIM-DLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRG----SC 125
               ::.||||||    ::..:||:: ||..|           .:.:|....|:.:...|    ..
  Fly    71 ITTKVPYIYYSPENLVLAAVIEDVVHDLKAV-----------GSKAFASASELNKALIGKDTYGY 124

  Fly   126 FAIDFHRVPNRGSDRKF--------------RYSLSSNQMRISPRKRFVNDEEIYHQIDDDDYIR 176
            ..|:|        |..|              |:.|   .:|.:|:..:.|...:.|...|.||.:
  Fly   125 VGIEF--------DDSFSDINELPINVTVGLRFPL---HLRKNPKMVWDNTSILKHSKMDVDYYQ 178

  Fly   177 -SGFLSLQHILDKQYMKYQELGKDF-EVVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVLLSSF 239
             .|||.:|..|.:..::.:...... ||::...|::..:....:|:...|    :||..|.:|:.
  Fly   179 VEGFLVVQAKLSEALIRAKNEAVVLPEVILQHYPDVAEVDRLDNRVALGG----VLFLPVTISAA 239

  Fly   240 VVP--FVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIF-VLVVAYLYKALGSICFAY 301
            .:.  .|.|:::.|::.|.|:...:::..|::||:.|:..::..:| ||::.:.|.:|..  .:.
  Fly   240 YLAQMIVMERRDHLRDMLELMGVRAWIYWLSWFLVAFLLLSIPTVFMVLLLKWRYFSLSD--SSL 302

  Fly   302 VAVLFLLYILSTMSYAYLISICFHS--------VFYAKIGGL--AMLIIPYAFSFVRSWATSLAF 356
            |....|:|.|..::.|::||..|..        |....||.|  .:|::.|..:..|:     .|
  Fly   303 VLFFLLVYNLEVLTSAFMISSFFSDTVGVQVAIVIVHLIGCLPWRLLLMGYVPTLPRT-----IF 362

  Fly   357 VCFSTNTFLE-GLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYL 420
            ||...|:.|. ||..|    .|.:|...|....:...:::......:..:|:|..|
  Fly   363 VCLFLNSSLAMGLQQF----IKSENLRLGLHWTYLFERTDWDEFVHLGPILLFMLF--------- 414

  Fly   421 GCVFPGPGGLK---------------RPMFFFLDPK---TYMKRQRNE------YTTTPRGTHAI 461
            ||:      |:               |..:|.:.|.   .:.:|.|::      ..|..|| |.:
  Fly   415 GCL------LRILVLAYMEQLRSYQNRKWYFPVQPSFWCRWNRRPRSDDFDVEGQETGIRG-HPL 472

  Fly   462 IITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCSE 526
            |:.  .:..:....:.:...:||:.....||||.||||.:||:|::.::.|.:...:|:|.: :.
  Fly   473 IVR--ARNIEKVFNEWIAVKDLNLNFYQDEITVFLGHNDSGKSTILMLLAGFLRPSAGEITI-NG 534

  Fly   527 RDVAS----YRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRN 587
            .|:|:    .|..:..|||.:|....:....||:|:.:|:|..|.:|....|:.|:...|.|..|
  Fly   535 YDLATNQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLKGLNRQEASAETDKYLEIGRLQDFAN 599

  Fly   588 EFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYME 652
            ...|||..|:||.|.|...:.||:||::||||.:.:|...|..:||:|...||.:.:::.||.|.
  Fly   600 TKVKNLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPAMRSNMWDLLRRERKGRCIIMATHNMN 664

  Fly   653 EAEVLGDTICILANGKLQSIGSPLELKRKSGIG--YRL---KLEINDFTSREVEIMEIIHHFVPT 712
            ||||:.|.|.:|.:.::...|:...|.:.:|.|  |.|   |::    |....|:...:....|.
  Fly   665 EAEVVADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLICTKMD----TCIVAEVTNFLQIRFPD 725

  Fly   713 ARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQ--- 774
            .::.|..:..|...||..|...:|.:...||....||.:..||:...:|..|||:...|..|
  Fly   726 IKLHNEFSIYVTYELPTKYVQQYAALFLELEEALGELNLAEISVCAPTLGSVFLQMGEEMRQSWN 790

  Fly   775 -VDTPDGSRNDAPLLAHYKRLQDHPPHRGLFQL------------WMAVFYKKWTF-ISNEWLYT 825
             :.:.|...:.:|:|:....|.       .|::            |.|:..||..| :.::..|.
  Fly   791 RISSFDLLSSPSPMLSLLNLLP-------TFEVREDDGRVKCCNQWRAIVEKKRLFTLRHQKFYC 848

  Fly   826 LIMLCIPFVC-------VFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAHLEQQL 883
            :|:.....:|       :| ..||.|.:|     |.|...||.....|..:.:|...:......:
  Fly   849 MIIATPIIICLLIISFSIF-IFLVDHHLS-----ELLVTDLSIYPKAVFVIDSPAEGNRFERHYM 907

  Fly   884 RQQIELNGITAKTMHLRGS-------NDVKNESLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTP 941
            ...|...|....|   .|:       .:::::.:.:|...||              |....|:..
  Fly   908 ANVIGQGGTVRST---SGTPIDDYLLAEMESDQVKVQHTFLA--------------GATFDSNAN 955

  Fly   942 TIEIFYSGNRY-HSSVELINLVDSAMLKLGRPESEIDTTYV--PIRRFVSD-----ISPSRLEYY 998
            :| |.:|.|:. |.|...:.||.:|   :|:..:::|...|  |.:..|..     |..|.:| :
  Fly   956 SI-IAWSNNKLKHGSALSMGLVYAA---IGQELAKLDIRIVNKPYQDTVQQAVRGLIYASTIE-F 1015

  Fly   999 AVIVPIGMFFFMF----YFISLPFREYANGFKQLQ---TMSRFTYWFAHFTFDMLILIFVCVALF 1056
            ||:|    |.::.    .|..||..|..:..:..|   .|||.|||.:|.::|....|.:.:.|.
  Fly  1016 AVLV----FHYLVLGTAIFAVLPIVERRSKVQHQQFSSGMSRSTYWLSHLSWDYCFYIAMILPLI 1076

  Fly  1057 SLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYL----LLMLIVSAI 1117
            .:..:.:.|.|....:|    |:..|...|:..:|..:.|:|..:.:|..|:    :|.|.:...
  Fly  1077 VVAGITIGSVLPVIVQL----LAFGFSAISFTYLLCLMSNDFGKMFSIILYINMIGVLALFIHPK 1137

  Fly  1118 APLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGL---ISQDTF--- 1176
            :|             :|:.|               :|....:...|.:|..|:   |...||
  Fly  1138 SP-------------QTRYA---------------VIESVLLVHPHYSLCCGMYEAIRMSTFSLK 1174

  Fly  1177 -FAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEK 1240
             ..|....|.   |:.|||             ::.|..:|..|    ...|....:|....::|.
  Fly  1175 QLPYLIFSGA---AYLTIV-------------VFAWVPRRLNY----VFKSIRNEKIYPSYKDED 1219

  Fly  1241 RVTDLIKDPL----NDH----SLIVHNLRKRYGDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTF 1297
            :..|.::..|    ..|    .||:.||.||||..:||..::......||.||||.||:||:|.|
  Fly  1220 KEVDKMRRRLAYLTTAHYAFFPLILKNLSKRYGSFVAVRSLTLDLNPFECVGLLGRNGSGKSSIF 1284

  Fly  1298 QMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRT 1362
            :||.....:..|:|.|||..::........:.|:||:...|..|||.:..|.:..|:.|:.|
  Fly  1285 RMIVGMESITVGSIHIKGYSLKTRPKDASRHVGFCPRELMLLSFMTGKDALRFCCLINGIRR--- 1346

  Fly  1363 DGPASCKEHVKYWL----EKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVD 1423
                   |::|..:    |...|..:...::..||.||||||:.||..: ||:|:.|||||.|||
  Fly  1347 -------EYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLMIAMGTL-APSLMCLDEPTAGVD 1403

  Fly  1424 PISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSGFTIKL 1488
            ..::..:|..:...:...|:::||:|:::|||.||..:.||.||...|..::..||......|.:
  Fly  1404 MHAKYEIWSILDGIRQGGRSILLTTHNLEECEFLCTNVGIMDHGSLLCYGSLSRLKHRFNMGIFV 1468

  Fly  1489 KMKADTETEM---------------NVSTITGT-------------------------------- 1506
            |:|..|..||               |.|.:..|
  Fly  1469 KVKMGTRAEMDDERDNWMQITMMPPNDSEMGSTVGARRMMLAHLLRHHNPPVEPVKKSRTSRAQP 1533

  Fly  1507 --------LKSEFPGL--ELRE---------------SHAGTLTYFVSTQESVVLWSSVFKIAEE 1546
                    ::.::..|  ||.|               |:.|.:|:.:...:  :.||::|:..|.
  Fly  1534 DTTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRGMITFCIPRGQ--IKWSAIFEYMEN 1596

  Fly  1547 YLGDRLSALVADYSVNECTLEDIFLKFERE 1576
             |.|.:..|.  |||:..|.:|:|:||.|:
  Fly  1597 -LKDEMQILY--YSVSHTTFQDVFMKFVRK 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	34/150 (23%)
		CcmA	460..767	CDD:224054	94/315 (30%)
		ABC_subfamily_A	461..679	CDD:213230	70/221 (32%)
		ABC2_membrane_3	<937..1117	CDD:289468	50/198 (25%)
		ABC_subfamily_A	1255..1479	CDD:213230	80/227 (35%)
		drrA	1262..1573	CDD:130256	107/386 (28%)
CG8908	NP_611464.3	ABC2_membrane_3	69..394	CDD:289468	82/361 (23%)
		LivG	471..686	CDD:223488	69/217 (32%)
		ABC_subfamily_A	474..691	CDD:213230	69/219 (32%)
		ABC2_membrane_3	845..1192	CDD:289468	88/426 (21%)
		NatA	1242..1461	CDD:226927	82/229 (36%)
		ABC_subfamily_A	1242..1459	CDD:213230	80/227 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444764
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	10	9.900