DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca14

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_038957098.1	Gene:	Abca14 / 365362	RGDID:	1561491	Length:	1691	Species:	Rattus norvegicus

Alignment Length:	1773	Identity:	471/1773 - (26%)
Similarity:	788/1773 - (44%)	Gaps:	308/1773 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FFVFLRKNLLYLQRN----LLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLR--EL 67
            |.|.|.||.|...|.    ::.::||...|...||          :.:|::.:....|:..  .|
  Rat    20 FLVLLWKNFLLKSRKVFGLVVEIILIFLLFVWTLT----------VRRISKKKFIPAMIFNPIPL 74

  Fly    68 YFPG---NELDY-IYYSPISPN-VEDIMDLLRVDL-------GIIPERLRPNNNSFEMQLEMEQQ 120
            ..||   ...|| :.|.|...| ..:|.::::.||       |...|      .|||..::.|.:
  Rat    75 TLPGFLNQNFDYELAYVPSDSNAARNITEMVKKDLNFNFKVQGFSSE------ESFEKYIKYEDK 133

  Fly   121 CRGSCFAIDFHRVPNRGSDRKF-----------RYSLSSNQM----------------------- 151
            ......||.|        |.||           :|||...:|
  Rat   134 AEHVLAAIVF--------DHKFKTSNEPLPLQVKYSLRFGRMYDPENVLKPSERQKETEWNTSIL 190

  Fly   152 -----RISPRKRFVNDEEIYHQIDDDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNME 211
                 .:.||....||.      .:..|||.|||.:||.:||..|.:.. |:..|.:.::
  Rat   191 FPSVPSLGPRNVLENDG------GNPGYIREGFLLVQHSVDKAIMMHHS-GRAAEAMFAN----- 243

  Fly   212 VISMDSHRLTY-------FGTLCSILFNVVLLSSF-------VVPFVEEKQNGLKEFLNLVTPMS 262
             .::.:.|..|       |.....::|...:|.:|       :...:.||:..|||:..:|...:
  Rat   244 -TTIYARRFPYPAFIHDNFLWTFIVMFPWTILFTFTQMALDIIGTIMLEKEKRLKEYQLMVGLSN 307

  Fly   263 FLNGLTFFLIRFVCYTLLMIFVLVVAYLYKALGSICF-----AYVAVLFLLYILSTMSYAYLISI 322
            .:..:::|:...:.|.:::..:..:.:| |......|     .::|..||.:.:|:|...::||.
  Rat   308 AMLWVSYFITFLLMYFIIICLLCGILFL-KITHERVFQHSDPLFIAFYFLCFAISSMLLGFMIST 371

  Fly   323 CFHSVFYA-KIGGLA--MLIIPYAFSFVRSWATSLA---FVCFSTNTFLE-GLDIFQTFSNKRKN 380
            .|:....| .|.|..  :...||...|.....|||:   .:|..|||.|. |.|:......|...
  Rat   372 FFNRASLATSIAGFLHFLTFFPYLIVFSLYDQTSLSGKLALCLITNTALAFGTDLICKLEMKGHG 436

  Fly   381 RE---FGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKT 442
            .:   |..    :|...:..|:..:..:.:|.:|||.::..|:..||||..|:.:|..|||. ||
  Rat   437 AQWYNFAT----KVNPDDDLTLAHIIGMFLFSAFLYGLVAWYVDAVFPGKYGVPKPWNFFLQ-KT 496

  Fly   443 Y------MKRQRNEYTTTPRGTH----------AIIITELCKKFQTSKRDTLIS-DNLNMTINNK 490
            |      :.|:.::.:..|....          .|.|..|.|:| |.|..||:: .:|::.:...
  Rat   497 YWFGEPALSREESQVSDLPPSDFMEPEPVDLEAGIQIQHLYKEF-TLKNSTLMAVKDLSLNLYEG 560

  Fly   491 EITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCH 552
            :||||||||||||||.::::.||.....||:.:..   ..|:...|..:|.|||..:....:|..
  Rat   561 QITVLLGHNGAGKTTTLSILTGLYLPTKGKVYISGYDISSDMVQVRKSLGLCPQDDLLFPLLTVS 625

  Fly   553 QHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILD 617
            :||.|:..::|...::........|...||..|.|...|:|||||||:||:.||:.|:||:||||
  Rat   626 EHLYFYCVIKGISSTNRPREIHRMLTSFGLLQKSNTMSKDLSGGMKRKLSIIIALIGDTKVVILD 690

  Fly   618 EPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKS 682
            ||:||:|..|||.:||:|.:.:|::.:|:|||:|:||:||||.|.||..|.|:..||.|.||:..
  Rat   691 EPTSGMDPVSRRAIWDLLQHYKKDRTILLTTHHMDEADVLGDRIAILVMGVLKCCGSSLFLKKLY 755

  Fly   683 GIGYRLKLEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESK 747
            |:||.|.: :....|.:.:|.::|.:::|||.:...|...:...||..:.:.||::...||...:
  Rat   756 GVGYHLVI-VKTPDSDDGKISQLIKNYIPTAEMETNVAAELSFILPKEHTHRFAELFTDLEERQE 819

  Fly   748 ELGIHTISMTDTSLEDVFLRCAGEQD-QVDT----------PDGSRNDAPL--------LAHYKR 793
            ||||....::.|::::||.:.:...| :::|          |..|.|:..:        ..:..|
  Rat   820 ELGISGFGVSMTTMDEVFFKVSNLADLKLNTEIAQSASTVNPSTSENNENMNVPRNFERSGYSGR 884

  Fly   794 LQDHPPHRG---LFQLWMAVFYKKWTFISNEWLYTLIMLC----IPFVCVFGAILVMHAMSLVEN 851
            ..|...:.|   ..|.:.|:|.|:..|....|...|:.|.    :.:|.:.|.     ..| |..
  Rat   885 YSDSSFNAGWPLYMQQFRAMFIKRVMFSWRNWKLLLLQLLALQGLTYVLIKGI-----GFS-VPK 943

  Fly   852 EEALPLKLSQMGSGVIYVHNP--TGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQR 914
            |.|..:.|.|.|...:    |  ......|.|:|.:.:|:.           ..|.|.:..::|
  Rat   944 EPARVMDLEQYGETTV----PFSVSGDPPLTQKLTKNLEIM-----------LKDKKQKVHEVQ- 992

  Fly   915 DNLADFLEQ---------VIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLK-L 969
            ..:.|:|..         |...:|:      |....|...:::...||:|...::::|:.:.| |
  Rat   993 GGVQDYLLTNKDCIYSCIVAFSLDV------TRKEKTFTFWFNNEAYHASPLSLSILDNIIFKYL 1051

  Fly   970 GRPESEIDTTYVP-IRRFVSDISPSRLEYYAVIV---PIGMFFFMFYFISLPFREYANGFKQLQT 1030
            ..|::.|..:..| .:.|....|..|......||   ..||..|...|..:...|..:..|.:|.
  Rat  1052 SGPDATITVSNKPQPQPFTKGRSEERSASGIQIVFNLLFGMSIFTSGFCLMTVTERVSKAKHIQF 1116

  Fly  1031 MS---RFTYWFAHFTFDMLILIFVCVALFSLQSLMMPSELYTTAELKV-------IVLSIFFYGC 1085
            :|   ...:|.:...:|::|....||       |::...|||...:.:       .:|.:..:|.
  Rat  1117 VSGVYTLNFWLSALLWDLIIHFVACV-------LLLLVFLYTDVHILLENYNFLDTMLILMLFGW 1174

  Fly  1086 SYLPILYALGNNFKSISTISTYL----------LLMLIVSAIAPLITSSNAAAMKLHETKIAFLC 1140
            |.:|.:|.|  :|...::.:.|:          .:.:||.|:..||.....:...|   .:..|.
  Rat  1175 SIIPFIYLL--SFWYNNSTNAYIKIFVFNHCLGFMSIIVDAVVELIPDIKTSTKNL---ILNSLL 1234

  Fly  1141 FLPDFNLNHQ-FRIINENFITRRHPALIKGLISQDTFFA-----------------YATAVGV-- 1185
            .||.:|.... |:..:...|.:    |...|.|.:||..                 :.||:..
  Rat  1235 LLPIYNFGMSIFKYYSIQEIRK----LCSSLGSLNTFSGCQHELTVYSMDKRAIGRHVTAMAATG 1295

  Fly  1186 MVMAFFTIVLE------HKYLRRRIHDGIWEWAFQ-RKKYNSTGTLPSTPISEIDDCAREEKRVT 1243
            ::...|.|:||      ..::.|.:..||::..:: |.....:|.      ||.:|...|.:.:.
  Rat  1296 LIYFLFIILLETTSWNLKAFIYRYVLFGIYKIFYKARMSKELSGD------SEDEDVQNERETIL 1354

  Fly  1244 DLIKDPLNDHSLIVHNLRKRY---GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLP 1305
            ......||. ::::..|.|.|   ...|||..:|....:.|||||||:||||||:||:::.....
  Rat  1355 QHSWHSLNS-TVLIKKLIKIYFKIPPTLAVRNISLTIQKEECFGLLGLNGAGKTTTFKILTGEEI 1418

  Fly  1306 LDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKE 1370
            ...|.:.|:|..|..:.||.|...|||||:|||..:||:.:.|...|.:.|:...      :.:.
  Rat  1419 ATSGDVFIEGYSITRNILKVRSKIGYCPQFDALLDYMTSREILTMYARVWGIPEN------NIRS 1477

  Fly  1371 HVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIK 1435
            :|...|:.::|....:..:...|||.||:|..|:|::|..::|.||||:||:||::||.||..:.
  Rat  1478 YVNNLLKMLYLKPQAEKFIYTLSGGNKRRLSTAIAIMGNSSVVFLDEPSTGMDPLARRMLWNAVI 1542

  Fly  1436 DFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSG--FTIKLKMKADTETEM 1498
            ..:...:.:::|||||:|||.||.|||||..||..||.:...||...|  :|:.:|.|..|:.::
  Rat  1543 RTRESGKVIIITSHSMEECEALCTRLAIMVQGKLVCLGSPQHLKNKFGNIYTMNIKFKTGTDDDV 1607

  Fly  1499 NVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNE 1563
             |..:...:...|||.:|::.:.|.|.|::.::::  .|..||.|.|:...|   ..:.|||:::
  Rat  1608 -VQDLKNYIAEVFPGSDLKQENQGILNYYIPSKDN--SWGKVFGILEKAKED---YNLEDYSISQ 1666

  Fly  1564 CTLEDIFLKFEREAKSQS 1581
            .|||.:||.|.....::|
  Rat  1667 ITLEQVFLTFANPDNTES 1684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	30/159 (19%)
		CcmA	460..767	CDD:224054	120/310 (39%)
		ABC_subfamily_A	461..679	CDD:213230	94/221 (43%)
		ABC2_membrane_3	<937..1117	CDD:289468	43/204 (21%)
		ABC_subfamily_A	1255..1479	CDD:213230	86/226 (38%)
		drrA	1262..1573	CDD:130256	114/315 (36%)
Abca14	XP_038957098.1	rim_protein	<100..1681	CDD:130324	448/1678 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860