DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and CG1801

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_728408.3	Gene:	CG1801 / 33104	FlyBaseID:	FBgn0031171	Length:	1655	Species:	Drosophila melanogaster

Alignment Length:	1794	Identity:	377/1794 - (21%)
Similarity:	708/1794 - (39%)	Gaps:	393/1794 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFFVFLRKNLLYLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQ----INQFEAKNEMVLRELY 68
            ||..::|..|...:|.|..::.:   ...||..:|:    |:.|.    ....|.:||.
  Fly     8 LFKRYIRIELNLWRRTLFEIVAL---VIMVLVIFLN----PIAHSKRLLYTTTENENEQ------ 59

  Fly    69 FPGNELDYIYYSPISPNVEDIMDLLRVD----------LGIIPERL--------------RPNNN 109
                       |.:|..::||..|.|:.          |...||..              ..:..
  Fly    60 -----------SIVSHKLQDINILTRMADSKREKTKYILAFTPETTFTSEVTKNVAKTLELSSTV 113

  Fly   110 SFEMQLEMEQQC--RGSCFAIDFHRVPNRGSDRKFRYSL--SSNQMRISPRKRFVNDEEIY---- 166
            .:|.:.||:.|.  |.:...|.|:.:.:.|:......|:  .|....|:|   |:.::.::
  Fly   114 GYESESEMQNQFDERTTLAGIVFNDLRDDGTPLTLSISIRFPSEFRTIAP---FLTEDRLWITRC 175

  Fly   167 ------------HQIDDDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSM--PNMEVISMDS 217
                        |....|.|||.|||.|||.:..::  |.:|.||   :||:.  ||:||.::
  Fly   176 SGRINPGRDRAKHDKQQDIYIREGFLQLQHQIFVEW--YHQLRKD---IVSTYPEPNVEVYNI-- 233

  Fly   218 HRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMS-----------FLNGLTF-- 269
             .|......||:: :|..|.:|:..|:.     |..|||::..::           :..|.:|
  Fly   234 -LLKAADEPCSVM-SVAQLPTFLYNFIY-----LLPFLNIIRNVAAQVEDGVMVHQWHYGYSFGM 291

  Fly   270 -----FLIRF--VCYTLLMIFVLVVAYL--------YKALGSICFAYVAVLFLLYILST-MSYAY 318
                 ||:.|  :|...::..::::|:.        :...|:|.|.....|:.:.|:.| |..|.
  Fly   292 QWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGTGTIAFVCFITLYTVEIIITGMVVAK 356

  Fly   319 LISICFHSVFYAKIGGLAMLIIPY-AFSFV--RSWATSLAFVCFSTNTFLEGLDIFQTFSNKRKN 380
            |.:...::|.:|    |.:.:..| ||..:  |.|.....:|.|          |...|.|.:.:
  Fly   357 LFANPTNAVLFA----LMLWLFMYAAFCIILERYWDIHKYYVFF----------ILVAFCNCQMH 407

  Fly   381 REFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCV-----FPGPGGLKRPMFFFLDP 440
               .::.:||........:.::..||:|.|.:.:.|..:|..:     .||.         ||..
  Fly   408 ---FSMSLFRNCIEKPEMVNTIDFVLIFTSAISSALIYFLILLAIQWRMPGT---------FLSR 460

  Fly   441 KTYMKRQR--NEYTTTPRGTHAIIITELCKKFQ-------------------TSKRDT--LISDN 482
            :....|.|  .|..||      |:.......||                   ||.||:  .|..|
  Fly   461 RIVNNRPRKQQESDTT------IMYLGRAPSFQNFEFGDVGSVELMRLRHVSTSHRDSERKILKN 519

  Fly   483 LNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCSE--RDVASYRHLIGFCPQHSVF 545
            ::|.|...|:.|:|||.|:||.|::.::.||.....|.:.:...  ......|.|:.|.......
  Fly   520 ISMRIYRGEVFVILGHIGSGKLTLLRILAGLKFPLRGNVYIMGNPFEPNGEARRLVDFRFDEHGL 584

  Fly   546 MSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNE-----FGKNLSGGMKRRLSLGI 605
            ..::|..|.:::..:|: ...|::..:..|:.|.|.:.|:..|     .||..||.|| .::|..
  Fly   585 NKHLTVEQTIDYHVRLK-LSPSESDRYEIERRKWLAILDQHVESRGVRIGKLSSGSMK-LVALCC 647

  Fly   606 AIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQ 670
            .:||:|.|:||:||::.|.....:..|.|:...::.:|.::.|:.:.|||.:.|.|.||:.|.|:
  Fly   648 CLAGDTPIIILEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLE 712

  Fly   671 SIGSPLELKRKSGIGYRL----KLEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAY 731
            :.|:|..|:.|......|    |..:.|     ..|.:.|:.|:......|.:..::...||..|
  Fly   713 ASGTPFFLRSKFSSSVDLVIIKKPHVPD-----QPITDYINQFMQNIEPENEIGDSLTYRLPVIY 772

  Fly   732 KNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGE---QDQVDTPDGSRNDAPLLAHYKR 793
            :....::|..||.:.|.|||..:.:....|.|:::.....   |.|: .||.::.....:...|:
  Fly   773 RPRLQKLLIHLEIDRKMLGIENVRVVGAELSDIYMTLVTSFRLQQQM-IPDVTQTFKYQVVSQKQ 836

  Fly   794 LQDHPPHRGLFQLWMAVFYKKWTFIS-NEWLYTLIMLCIPFVCVFGAILVMHAMSL---VENEEA 854
            |..        |...|:||||....: |.|  .:||:...||.:  ||:...::.|   .|.:.:
  Fly   837 LTK--------QRMRAMFYKKMIHTAPNVW--PIIMIFTSFVLI--AIIARLSVLLDMPKERQNS 889

  Fly   855 LPLKLSQMGSGVIYVHN--PTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQ---- 913
            :.:...:....|.|:.|  ..|:     ..:|..:::|    |...:..|....::|...:
  Fly   890 IHIGFREPEDVVKYLPNLKDCGY-----IDIRSAVKVN----KKKSVGVSRTFDDDSFVCEKGSY 945

  Fly   914 RDNLADFLEQVIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRP------ 972
            |:||....|     :..:|......| ..:..:.|.:.:||:..::||:.:.:|:|..|
  Fly   946 RNNLRKKNE-----LRSFGAVESDGD-EHLNGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLV 1004

  Fly   973 -------------------ESEIDTTYVPIRRFVSDISPSRLEYYAVIVPIGMFFFMFYFI---- 1014
                               :::|...:||:             ....|:|:.:..|:...:
  Fly  1005 VLVENHPLPTQLSQKINVLDNKIAHIHVPL-------------VVGCIIPLTVSVFVIPLVEEEI 1056

  Fly  1015 -SLPFREY--ANGFKQLQTMSRFTYWFAHFTFDMLILIFVCVALFSLQSLMMPS--ELYTTAELK 1074
             .:.|.::  ..|.|....::.|..||..|.:.::|::        :.|||...  ..|..| :.
  Fly  1057 YDVRFLQHMAGLGLKVFWGINLFWDWFTFFVYSVIIVV--------IMSLMGIGGFGFYENA-IM 1112

  Fly  1075 VIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLI--VSAIAPLITSSNAAAMKLHETKIA 1137
            |::|:.|  |.:.||:.| |.:.|.:.|.:..:|:.:|:  ||.:...|...:.|    :...|.
  Fly  1113 VVLLTTF--GLAALPLTY-LVSMFVNKSIVRAFLVSVLLQGVSGLVLYIIYWDVA----NSNTIF 1170

  Fly  1138 F--LCFLPDFN-LNHQFRIINENF--------------ITRRHPALIKGLISQDTFFAYATAVGV 1185
            |  .|..|.|: |:....:..:|.              .|..:...:......||||.:| |.|:
  Fly  1171 FYAACMSPGFSLLDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKFDTFFKWA-APGI 1234

  Fly  1186 ------MVMA--FFTIVLEHKYLRRRIHDGIWEWAFQRKKYNS--------TGTLPSTPISEIDD 1234
                  ||::  .|.:::....|.||           .||:::        |.|.|    .:..|
  Fly  1235 LPPILYMVLSALIFLMLIFWIELHRR-----------EKKFHTSRDLRKMRTATYP----FDDGD 1284

  Fly  1235 CAREEKRVTDLIKDPLNDHSLIVHNLRKRY---GDKLAVDGVSFAAAQGECFGLLGVNGAGKTST 1296
            .|..::::.:...........:|..:..|.   |.:  :..||||..:....|:.|...:||:..
  Fly  1285 VADVKQKIAEADNTKAKQSVFLVDQVEARVPAAGKR--IHTVSFALNKYMSMGIFGPRNSGKSHL 1347

  Fly  1297 FQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRR 1361
            .:.:........|.|.::|.|.:........|.||.||:..|...:|..:.:..:.::||:...:
  Fly  1348 MRQLVGQRGFAFGEIYVRGLDFKYDLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAK 1412

  Fly  1362 TDGPASCKEHVKYWLEKMH-------LTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPT 1419
            ..             ||||       :|.:...:....:...:.||..|:|::....:::|||||
  Fly  1413 IG-------------EKMHDLCLMLNMTGWMHRKCSLLTAEKRHKLKIALALVAYNKILVLDEPT 1464

  Fly  1420 TGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICAL--KRLS 1482
            .|:...:||.:|..::..:...:|::..::...||:.|.:.:.:....:...:.::..|  |...
  Fly  1465 CGMPATTRREIWNILRYIRYCGKTIIFATNDELECKILADFIILFQDSEMLAIGSLQYLRYKYSH 1529

  Fly  1483 GFTIKLKMKAD----TETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESV--VLWSSVF 1541
            ||.:::::..|    .|:|.|:......|......|..|....|.|..:......|  :::|.::
  Fly  1530 GFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLHNRSELVGRLNNWFKFYVPVGHIVYSFLY 1594

  Fly  1542 KIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQ 1580
            ...|:   ::|...|:||.:.:..:..:..:.: |.::|
  Fly  1595 GAMEK---NKLRLNVSDYCIYQADMMSVVAQVQ-ETRAQ 1629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	36/167 (22%)
		CcmA	460..767	CDD:224054	87/338 (26%)
		ABC_subfamily_A	461..679	CDD:213230	66/245 (27%)
		ABC2_membrane_3	<937..1117	CDD:289468	42/215 (20%)
		ABC_subfamily_A	1255..1479	CDD:213230	47/235 (20%)
		drrA	1262..1573	CDD:130256	65/328 (20%)
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:289468	28/141 (20%)
		ABC2_membrane_4	<293..448	CDD:289500	35/171 (20%)
		EcfA2	499..717	CDD:224047	62/219 (28%)
		P-loop_NTPase	500..721	CDD:304359	63/222 (28%)
		ABC2_membrane_3	<972..1254	CDD:289468	61/311 (20%)
		EcfA2	1307..1521	CDD:224047	46/228 (20%)
		P-loop_NTPase	1324..1524	CDD:304359	43/212 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451219
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	10	9.900