DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and ABCA

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster

Alignment Length:	1774	Identity:	462/1774 - (26%)
Similarity:	789/1774 - (44%)	Gaps:	325/1774 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YLQRNLLPLLLI-----CSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPGNELDYIY 78
            |.::||..|.|:     .|.:.|.|.|.    :.|...:.|...:|.|.:|             .
  Fly    59 YNEQNLTDLNLLQHSLHRSSYLGKLIAL----IAPNRRRKNGGFSKFEFIL-------------C 106

  Fly    79 YSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCFAIDF-----HRVPNRGS 138
            |||::|.::.:::.....||  ..::..:.|:  .|||::...:.:...:.|     :...|...
  Fly   107 YSPVNPVLKKLVEEAWQSLG--KNKICESENA--TQLELDTVSKNAFAGVQFDDAWANLTENDPL 167

  Fly   139 DRKFRYSLS------------SN---QMRISPRKRFVNDEEIYHQIDDD-----DYIRSGFLSLQ 183
            ...|.::|.            :|   .||:.|........   ::.|||     .|:|.|||.||
  Fly   168 PNDFHFALRFPAELRTATIAIANTWLTMRLFPTIDLTGPR---NEGDDDGGIPPGYLREGFLPLQ 229

  Fly   184 HILDKQYMKYQELGKDF-EVVVSSMPNMEVISMDSHRLTYFGTL---CSILFNVVLLSSFVVP-- 242
            |.|...|::.:...:|. .||:...|....|         |..|   .|.:.::::|.||:.|
  Fly   230 HSLSMAYLRQKSGEQDLPNVVMKRYPFPAYI---------FDPLLEGMSSIMSLIILLSFIYPCT 285

  Fly   243 -----FVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVVAYLYK--------AL 294
                 ...||:..|||.:.::...::|:...:|:..|:   :|.|..:::|.|.|        .|
  Fly   286 YITKYITAEKEKQLKEVMKIMGLSNWLHWTAWFVKSFI---MLTISAILIAILVKINWSEDVAVL 347

  Fly   295 GSICFAYVAVLFLLYILSTMSYAYLISICF-HSVFYAKIGGLAMLI--IPYAFSFVRSW-----A 351
            ....|..:....::||:|::.:.::::..| .:...|.:.||...|  |||:|: :.|:     :
  Fly   348 THANFTALVFFLIIYIVSSICFCFMMATFFSRASTAAAVTGLIWFIAYIPYSFT-INSYDDLSLS 411

  Fly   352 TSLAFVCFSTNTFLEGLDIFQTFSNKRKNRE----FGAVDVFRVIKSNSSTMFSVYVVLVFQSFL 412
            :.|.:...|......|:.:...|....:..:    |..|.|     .::.|:.:|.::::....:
  Fly   412 SKLGWSLISNTAMGFGIKLILGFEGTGEGLQWSNFFTPVSV-----DDTLTLGAVMIMMLVSCVI 471

  Fly   413 YAMLYNYLGCVFPGPGGLKRP------MFFFLDPKTYM-----------KRQRNEYTTTPRGTH- 459
            |.::..|:..|.||..|:.||      ..|:...:.|.           :|....:.|.|.|.|
  Fly   472 YMIICLYVEQVMPGSFGVPRPWNFPFTREFWCGEREYTGVEDIPNGHVEQRDPKAFETEPEGKHI 536

  Fly   460 AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVC 524
            .:.:..|.|:|    .:.::...|:|.:...|||||||||||||||.::|:.|:.|..||..|:.
  Fly   537 GLQMRHLKKRF----GNKMVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTSGTAIIN 597

  Fly   525 S---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKR 586
            .   ..::...|..:|.||||:|....|:...|:.||::::|...........:.||.:.|.||.
  Fly   598 GSDIRTNIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYLKMIELEDKA 662

  Fly   587 NEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYM 651
            |.....|||||||:||:..|:.|:||:|:.||||||:|.::||:|||:|...:..:.:|:|||:|
  Fly   663 NVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWDLLQQEKVGRTLLLTTHFM 727

  Fly   652 EEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRL------KLEINDFTSREVEIMEIIHHFV 710
            :||:||||.|.|:.:|:|:..|:...||::.|.||||      ..|.|:.|:       :::.::
  Fly   728 DEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTA-------LLNKYI 785

  Fly   711 PTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQV 775
            |..:....:...:...||.:....|.:|..:||.:|.||.::...:..||:|:||::...|:|..
  Fly   786 PGLKPECDIGAELSYQLPDSASAKFEEMFGQLEEQSDELHLNGYGVGITSMEEVFMKVGAEKDNT 850

  Fly   776 -------------------DTPDGSRNDAPLLAHYKRLQDHPPHRGLFQL---WMAVFYKKWTFI 818
                               |..:..::|.....:.:.||      ||..|   |.|:..||:.:.
  Fly   851 GNIKDQHEIMNGGSGFRGEDDNESVQSDGIFSENRRLLQ------GLQLLSNQWKAMLLKKFLYT 909

  Fly   819 SNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIY-----VHNPTGHH-A 877
            ....|..||...:|...|...||::......:..:.:.:.|:|....|..     |.|.||:. |
  Fly   910 WRNKLLLLIQNIMPVFFVVVTILIIKTQGTFQELKPITISLTQYPLAVTVLDRSNVQNGTGYEIA 974

  Fly   878 HLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVIGIIDMYGGGR----GTS 938
            :..:.|.:....|    ..:.|.|:...::..|||.:            .|.:....|    .|.
  Fly   975 NKYEDLARSYGSN----YGLELTGTQGFEDYILDLGK------------TIQVRINSRYLVAATI 1023

  Fly   939 DTPTIEIFYSGNRYHSSVELINLVDSAML-KLGRPESEIDTTYVPIRRFVSDISPSRLE------ 996
            ....|..:.:....|::...:|:|.:|:. ||.....:|..|..|:....|.:. |:|.
  Fly  1024 TESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTTSTLL-SQLSTGNNLG 1087

  Fly   997 -YYAVIVPIGMFFFMFYFISLPFREYANGFKQLQTMSR---FTYWFAHFTFD---------MLIL 1048
             ..|..:...|.|....:|....:|..:..|.||.:..   :|:|.:.|..|         ::::
  Fly  1088 TQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGVKVWTFWLSQFICDFASYIVTALIVVI 1152

  Fly  1049 IFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYAL-------GNNFKSISTIST 1106
            ..||         ...:.|.|..||....|.:..:|.:.||.:|.:       ...|..:|.::.
  Fly  1153 TIVC---------FQETGLSTFGELGRYYLLLLLFGFAVLPFIYIMSLFFREPATGFARVSIVNI 1208

  Fly  1107 YLLLMLIVSAIAPLITSSNAAAMKLHETKIA-------FLCFLPDFNLNHQFRIINENFITRR-- 1162
            :..:.|.:..:   :.||     :|.:||..       |..| |.|:|......:..|..||.
  Fly  1209 FCGMALFIVVV---VMSS-----ELFDTKDTADILGWIFRIF-PHFSLAMSLNKVYTNTATRNAC 1264

  Fly  1163 ------HPALIKGLISQ----DTFFA-----------YATAVGVMVMAFFTIVLEHKYLRRRIHD 1206
                  .|.|:..|:.|    ..:||           |....|| |.....||||.:.:.
  Fly  1265 AKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYMAVTGV-VFFLIIIVLEFRLIN----- 1323

  Fly  1207 GIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDKLAVD 1271
               |..|:.::..|....|.|.....||.|.|.:|:..:..:.|...:|::..:.|.||..:||:
  Fly  1324 ---ELMFKIRQLISKPPPPPTEGQLDDDVANERERILQMSSNELATKNLVLDRVTKYYGQFMAVN 1385

  Fly  1272 GVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYD 1336
            .||....:.||||||||||||||:||:|:..:..:..|...::|..:..:.....:..|||||:|
  Fly  1386 QVSLCVQEVECFGLLGVNGAGKTTTFKMMTGDERISSGAAYVQGLSLESNMNSIYKMIGYCPQFD 1450

  Fly  1337 ALNKFMTAEQCLYYMALLRGLS----RRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTK 1397
            ||...:|..:.|....:|||:.    |:.::..|.....:|      |:.|    |...||||.|
  Fly  1451 ALLDDLTGREVLRIFCMLRGVQESRIRQLSEDLAKSFGFMK------HIDK----QTHAYSGGNK 1505

  Fly  1398 RKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLA 1462
            |||..|:|:||:|:::.|||||||:||.:||.||..:...:...:::|||||||:|||.||.|||
  Fly  1506 RKLSTAIAVIGSPSVIYLDEPTTGMDPAARRQLWNMVCRIRDSGKSIVLTSHSMEECEALCTRLA 1570

  Fly  1463 IMAHGKFKCLNNICALKR--LSGFTIKLKMKADTE------------------------TEMNVS 1501
            ||.:|:|||:.:...||.  ..|..:|:|::.:.|                        ::.::.
  Fly  1571 IMVNGEFKCIGSTQHLKNKFSKGLILKIKVRRNLEALRQARLSGGYARNPDEQTVPAQMSQRDID 1635

  Fly  1502 TITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTL 1566
            .:...:::|:|...|:|.:.|.||:::..  :.|.||.:|.:.|.. .|:|:  |.||||::.||
  Fly  1636 AVKEFVETEYPNSILQEEYQGILTFYIPL--TGVKWSRIFGLMESN-RDQLN--VEDYSVSQTTL 1695

  Fly  1567 EDIFLKFEREAKSQSTSRQ 1585
            |:|||:|.:..:..:.:.|
  Fly  1696 EEIFLEFAKYQREDTRANQ 1714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	35/158 (22%)
		CcmA	460..767	CDD:224054	112/315 (36%)
		ABC_subfamily_A	461..679	CDD:213230	87/220 (40%)
		ABC2_membrane_3	<937..1117	CDD:289468	40/206 (19%)
		ABC_subfamily_A	1255..1479	CDD:213230	93/227 (41%)
		drrA	1262..1573	CDD:130256	123/340 (36%)
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500	40/192 (21%)
		ABC2_membrane_3	<269..475	CDD:289468	43/214 (20%)
		CcmA	538..843	CDD:224054	112/315 (36%)
		ABC_subfamily_A	538..755	CDD:213230	87/220 (40%)
		ABC2_membrane_3	913..1316	CDD:289468	87/438 (20%)
		ABC_subfamily_A	1369..1587	CDD:213230	93/227 (41%)
		drrA	1376..1702	CDD:130256	123/340 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451236
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	11	10.800