DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and CG1494

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster

Alignment Length:	1853	Identity:	386/1853 - (20%)
Similarity:	676/1853 - (36%)	Gaps:	476/1853 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLRKNLLYLQRN----------LLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRE 66
            ::||.||...:|          ||.:||:...|..|                        .||..
  Fly     6 YIRKFLLMNWKNHKLQLANPLELLVILLVPPLFTLV------------------------AVLMR 46

  Fly    67 LYFPGNELDYIYYSPIS------------PNVEDIMDLLRVD---------LGIIPER------- 103
            .:.|.|......|.||.            .....:.|...|.         :|..|:|
  Fly    47 FFIPVNHRSDTVYDPIDLDRSWMQMVEKLEKARQVADTYNVKGNPFTPHLVIGWAPKRYGIFQAM 111

  Fly   104 -------LRPNNN-SFEMQLEMEQQC------RGSCFAIDFHRVPNRGS----DRKFRYSLSSNQ 150
                   :.|..: .||...||.:..      .|.||         .||    |:.|......:.
  Fly   112 MRRVQKQIEPMTSVGFEDCEEMRESVIENGLFAGLCF---------DGSPFVEDQVFEEDTLESY 167

  Fly   151 MRISPRK-----------------RFVNDEEIYHQIDDDD-----------------YIRSGFLS 181
            ..|.|..                 |..|...:|:  ||.:                 |:|.||:.
  Fly   168 SNIQPMLNYTILLPSELRMLDGDFRMANWMTLYN--DDPNTFVLTRLNQPYEGGFVGYVREGFIR 230

  Fly   182 LQHILDKQYMKYQELGKDFEVVVS--SMPNMEVISMD---------SHRLTY---FGTLCSILFN 232
            ||          :.:.:.|.|:.|  |:|.:::....         ...|.|   |..:...||.
  Fly   231 LQ----------KSVSESFLVLTSHKSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFP 285

  Fly   233 VVLLSSFVVPFVEEKQNGLKEFL------NLVTPMS-FLNGLTFFLIRFVCYTLLMIFVLVVAYL 290
            ..|   ||...|.|||:.:::||      ||:..:| :|.||.:          .||..|::|.|
  Fly   286 AQL---FVWQVVSEKQSQVRQFLINMNIGNLIHFVSWYLKGLIY----------EMISSLIIAAL 337

  Fly   291 YKAL-----GSICFA--YVAVLFLL-YILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFV 347
            .|..     |.:...  |:.:|.|. |..:.:::|.:::..|.:.    :..:.:|.|.:..|:|
  Fly   338 LKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVAAFFRNA----LNAVRVLTILWIMSYV 398

  Fly   348 RSWATS---------LAFVCFSTNTFLEGL------------DIFQTFSNKRKNREFGAVDVFRV 391
            .::..|         |.:|.::....:..|            .|....|..|.|.:.|.:.|
  Fly   399 PTFILSNNLEGNIHALRYVSYALPNVVATLVIEFLIERESIVHITWEDSGYRLNYDGGHITV--- 460

  Fly   392 IKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPR 456
              :.||.:|          .|.|::|..:|.......|..|.......|.|....|.:.|  ..|
  Fly   461 --TASSWIF----------MLNALVYCAIGLYVDMWRGGDRSGKKMKKPNTNASVQEDPY--HER 511

  Fly   457 G---TH----------------------AIIITELCKKFQTSKRDTLISDNL-NMTINNKEITVL 495
            |   ||                      .:.|.:|||:|.|:.|..|   || :..:...|:|||
  Fly   512 GDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPAL---NLFSWNVYENEVTVL 573

  Fly   496 LGHNGAGKTTMMNMIMGLVPKDSGKIIVCS-----ERDVASYRHLIGFCPQHSVFMSYMTCHQHL 555
            :||||.||:|::.::.|||....|.:::.|     ||..||..  :|....|.:.::..|...:|
  Fly   574 MGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASME--LGIAFGHDMLLTGFTVIDYL 636

  Fly   556 EFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLS-GGMKRR------------LSLGIAI 607
            .|..:::|...:            :.:..:.|.|...|. ||:|.:            :|:..|.
  Fly   637 RFICRVKGLHNN------------IEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAF 689

  Fly   608 AGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSI 672
            .||:.|:::|:..|.||..::..:|:::...:.::.:::.::....||.:.|.:.|::||:|:..
  Fly   690 VGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCT 754

  Fly   673 GSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQ 737
            |:...||...|.||||.. :.....:..|:..:::.::|...:...:...|...|...:::.|..
  Fly   755 GTKPFLKNMYGHGYRLTC-VKGKNYKRDELFGMMNSYMPNMSIERDIGYKVTFVLENKFEDQFPM 818

  Fly   738 MLYRLETESKELGIHTISMTDTSLEDVFLRCAGE-QDQVDTPDGSRNDAPLLAHYKRLQDHPPHR 801
            ::..||...::||:.:..:.|||:|::|||...| .||........|...||..|.........:
  Fly   819 LIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQSGAFQSHENAQVLLEEYYSTLAEANEK 883

  Fly   802 GLFQLW-------MAVFYKKWTFISNEW---LYTLIMLCIPFVCVFGAILVMHAMSLVENEEALP 856
            |....|       .||.||:|......|   ::.::.:.:..||.|.:|.:..     :|.|..|
  Fly   884 GRRTGWKLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMALVAVCTFSSIFIYG-----KNYELEP 943

  Fly   857 L--KLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLAD 919
            |  .|||:.:...:|           :...::.::..:.|....|....|....:|...|.|...
  Fly   944 LTFNLSQLHTVDAFV-----------ELFSEEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYA 997

  Fly   920 FLEQ---VIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLK-LGRPESEIDTTY 980
            .|.|   ...:...|..| .|.|...:..:::....||:...:|:|.:|:.: |...|:.||.|.
  Fly   998 LLTQNQFTAHVNSRYIFG-ATFDQKIVTAWFNNIPLHSAPYALNVVHNAVARHLFDEEATIDVTL 1061

  Fly   981 VPI--RRFVSDISPSRLEYYAVIVPIGMFF--------FMFYFISLPFREYANGFKQLQTMSRF- 1034
            .|:  |..::...||. ..:...:..|:.|        |..|.|:    |..:..|:.|.::..
  Fly  1062 APLPFRTAINTFPPSS-HTFGGCLAFGICFVLTFIWPAFAIYMIT----ERGSLLKKQQFLAGVR 1121

  Fly  1035 --TYWFAHFTFDMLILIFVCVALFSLQSLM-MPSELYTTAELKVIVLSIFFYGCSYLPILYALGN 1096
              :||.....:|:|.|:..|..:..:.:|. .|:.            .:..||  |:.:...||.
  Fly  1122 VCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNH------------DVMLYG--YISVTLMLGG 1172

  Fly  1097 NFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKL-HETKIAFLCFLPDFNLNHQFRIINENFIT 1160
                       ..::|:...:|.|..:.....:.| ....|..:||       .||        .
  Fly  1173 -----------FWVILLAYLMASLCRNPCYGFLWLCGINSIGLVCF-------SQF--------Y 1211

  Fly  1161 RRHPALIKGLISQDTFFAYATAVGVMVMAF----------------------------------- 1190
            |.||   :.::.:.||.|..|...|:...|
  Fly  1212 RTHP---ESMLLEPTFMAMYTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCCIKSN 1273

  Fly  1191 ---FTIVLEHKYLRRRIHDGIWEWAFQRKKYNS----TGTLPSTPISEIDDCAREEKRVTDLIKD 1248
               ||..:.|..:...:.|.|........:|:|    ......|..:|..|..:|.:....::.
  Fly  1274 YGTFTAGIYHDLVILTLLDIILLACLFVSEYHSILGFADCRLDTRTNESPDSNQESRAFPGILS- 1337

  Fly  1249 PLNDHSLIV-----HNLRKRYGDKLAVDGV---------------SFAAAQGECFGLLGVNGAGK 1293
              ||.:.:|     ..|.:....|.|..|:               .|..|:.||..:.|.|.:||
  Fly  1338 --NDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGK 1400

  Fly  1294 TSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLS 1358
            |:..:::.....::.|.:.|....:..|.::.....|||||.|:|....|..:.||..|:|:|
  Fly  1401 TTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQG-- 1463

  Fly  1359 RRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVD 1423
            .|...|    :|..:..|..:.||......||..:.|..|:|..|.|::|:|.|:.:|....|:|
  Fly  1464 HRHRIG----RELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLD 1524

  Fly  1424 PISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKR--LSGFTI 1486
            |..:|.:.......|....:.:.|..:..:.|.|..|..::..|:...:..:.....  .||:.:
  Fly  1525 PTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQL 1589

  Fly  1487 KLKMKADTETEMNVSTITGTLKSEFP---------GLELRESHAGTLTYFVSTQESVV----LWS 1538
            :::.|......:::|..|..|.:.||         .:|::...| .||  :...:|:|    |.:
  Fly  1590 EVRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDA-VLT--IERDDSMVFVLPLGT 1651

  Fly  1539 SVFKIAEEYLGDRLSALVADYSVNECTLEDIFL 1571
            :.|  :|.:|..|..|.       |..:||.|:
  Fly  1652 TTF--SEIFLTLRKDAF-------EMNIEDYFI 1675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	36/164 (22%)
		CcmA	460..767	CDD:224054	81/325 (25%)
		ABC_subfamily_A	461..679	CDD:213230	60/236 (25%)
		ABC2_membrane_3	<937..1117	CDD:289468	38/194 (20%)
		ABC_subfamily_A	1255..1479	CDD:213230	57/243 (23%)
		drrA	1262..1573	CDD:130256	79/340 (23%)
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	54/248 (22%)
		CcmA	541..848	CDD:224054	81/324 (25%)
		ABC_subfamily_A	541..761	CDD:213230	60/236 (25%)
		ABC2_membrane_3	911..>1189	CDD:289468	63/324 (19%)
		ABC2_membrane	<1080..>1188	CDD:304374	24/136 (18%)
		ABC_subfamily_A	1370..1577	CDD:213230	52/212 (25%)
		PRK14255	1371..1586	CDD:172743	52/220 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451234
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	1	0.950	-	0	Normalized mean entropy	S12404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	11	10.850