Protein Alignment Eato and Abca1

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_038965774.1
• Gene: Abca1 / 313210
• RGDID: 631344
• Length: 2263
• Species: Rattus norvegicus
• Alignment Length: 1887
• Identity: 473/1887 - (25%)
• Similarity: 802/1887 - (42%)
• Gaps: 462/1887 - (24%)

  Fly    42 LHWSVKPVLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRV-------DLGI 99
            |.|:.:.::    .|.|||.   .::..|...: |.:....:...:.|..:.|.       .|..
  Rat   456 LDWTAQDIM----AFLAKNP---EDVQSPNGSV-YTWREAFNETNQAIQTISRFMECVNLNKLEP 512

  Fly   100 IPERLRPNNNSFEMQLEMEQQCRGSCF---AIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVN 161
            ||..:|..|.|.|: |:..:...|..|   ..|...:|:.     .:|.:   :|.|...:|...
  Rat   513 IPTEVRLINKSMEL-LDERKFWAGIVFTGITPDSVELPHH-----VKYKI---RMDIDNVERTNK 568

  Fly   162 DEEIY-------HQIDDDDYIRSGFLSLQHILDKQYMK-YQELGKDFEVVVSSMP-----NMEVI 213
            .::.|       ...:|..|:..||..||.::::..:: .....|...|.|..||     :...:
  Rat   569 IKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYVQQMPYPCYVDDIFL 633

  Fly   214 SMDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF------LI 272
            .:.|..:..|.||..|....|::.|.|.    ||:..|||.:.:   |...||:.:|      ||
  Rat   634 RVMSRSMPLFMTLAWIYSVAVIIKSIVY----EKEARLKETMRI---MGLDNGILWFSWFISSLI 691

  Fly   273 RFVCYTLLMIFVLVVAYLYK-ALGSICFAYVAVLFLLYILSTMSYAYLISICF-HSVFYAKIGGL 335
            ..:....|::.:|.:..|.. :..|:.|.:::|..::.||.    .:|||..| .:...|..||:
  Rat   692 PLLVSAGLLVIILKLGDLLPYSDPSVVFVFLSVFAVVTILQ----CFLISTLFSRTNLAAACGGI 752

  Fly   336 A--MLIIPY----------AFSFVRSWATSLAFVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDV 388
            .  .|.:||          .|| ::.:|:.|:.|.|..     |.:.|..|..:....::.  ::
  Rat   753 IYFTLYLPYVLCVAWQDYVGFS-IKIFASLLSPVAFGF-----GCEYFALFEEQGIGVQWD--NL 809

  Fly   389 FR-VIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFF----------FLDPKT 442
            |: .::.:...:.:...:::|.:|:|.::..|:..||||..|:.||.:|          .:|.|:
  Rat   810 FKSPVEEDGFNLTTSVSMMLFDTFIYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKS 874

  Fly   443 Y---MKRQRNEYTTTPRGTH---AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGA 501
            :   .::..:|.......||   .:.|..|.|.::...:  :..|.|.:.....:||..||||||
  Rat   875 HPGSSQKGASEICMEEEPTHLKLGVSIQNLVKVYRDGMK--VAVDGLALNFYEGQITSFLGHNGA 937

  Fly   502 GKTTMMNMIMGLVPKDSGKIIVCSE---RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRG 563
            ||||.|:::.||.|..||...:..:   .::.|.|..:|.||||:|....:|..:|:.|:|:|:|
  Rat   938 GKTTTMSILTGLFPPTSGTAYILGKDIRSEMNSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKG 1002

  Fly   564 ACRSDARDWADEKLKKLGL-SDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINS 627
            ......:...::....:|| ..|.......|||||:|:||:.:|..|.:|:||||||::|:|..|
  Rat  1003 LSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYS 1067

  Fly   628 RRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEI 692
            ||.:|::||..|:.:.::::||:|:||::|||.|.|:::|||..:||.|.||.:.|.||.|.|..
  Rat  1068 RRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVK 1132

  Fly   693 NDFTSR--------------------------------EVE-----------IMEIIHHFVPTAR 714
            .|..|.                                ||:           |..:|...|..||
  Rat  1133 KDVESSLSSCRNSSSTVSCLKKVVPELPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEAR 1197

  Fly   715 VLNVVNPTVYICLPY--AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVD- 776
            ::..:...:...|||  |.:..|.::.:.::....:|||.:..:::|:||::||:.| |:..||
  Rat  1198 LVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVA-EESGVDA 1261

  Fly   777 -TPDGSRNDAPLLAHYKRLQD-----HP--------PH-------------------RGLFQL-- 806
             |.||:   .|...:.:...|     ||        |:                   :|.:||
  Rat  1262 ETSDGT---LPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDLDPESRETDLLSGMDGKGSYQLKG 1323

  Fly   807 W-------MAVFYKKWTFI--SNEWLYTLIMLCIPFVCV----------FGAILVMHAMSLVENE 852
            |       :|:.:|:....  |.:..:..|:|...|||:          ||....:.....:.||
  Rat  1324 WKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPNLELQPWMYNE 1388

  Fly   853 ---------------------------------EALPL--------------------------- 857
                                             |..|:
  Rat  1389 QYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPNTPCLVGEEDWTTGPVPQTLMDLFQN 1453

  Fly   858 -----------------KLSQM------GSGVI-----------YVHNPTGHHAH---------- 878
                             |:.:|      |:|.:           .:.|.||.:..
  Rat  1454 GNWTMKNPSPSCQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQI 1518

  Fly   879 LEQQLRQQIELN---------GITAKTMHLRGSNDVKN------ESLDLQRDNLAD-FLEQVIGI 927
            :.:.|:.::.:|         |: :.:..|..|.:|.|      :.|.|.:|:.|| ||..:
  Rat  1519 IAKSLKNKVWVNEFRYGGFSLGV-SDSQALPPSQEVNNAIKQMKKLLKLTKDSSADRFLSSL--- 1579

  Fly   928 IDMYGGGR---GTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY-VPIRRFVS 988
                  ||   |......::::::...:|:....:|::::|:|:....:.|..:.| :.......
  Rat  1580 ------GRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPL 1638

  Fly   989 DISPSRLEYYA-------VIVPIGMFFFMFY----FISLPFREYANGFKQLQ---TMSRFTYWFA 1039
            :::..:|...|       |:|.|.:.|.|.:    |:....:|..:..|.||   .:....||.:
  Rat  1639 NLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFICGVKPVIYWLS 1703

  Fly  1040 HFTFDM---------LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALG 1095
            :|.:||         :::||:|   |..:|.:      ::..|.|:.|.:..||.|..|::|...
  Rat  1704 NFVWDMCNYVVPATLVVIIFIC---FQQKSYV------SSTNLPVLALLLLLYGWSITPLMYPAS 1759

  Fly  1096 NNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINE---- 1156
            ..||..||  .|::|..:...|.  |..|.|.             |:.:...|::|..||:
  Rat  1760 FVFKIPST--AYVVLTSVNLFIG--INGSVAT-------------FVLELFTNNKFNDINDILKS 1807

  Fly  1157 NFITRRHPALIKGLI---------------SQDTFFA-----------YATAVGVMVMAFFTIVL 1195
            .|:...|..|.:|||               .::.|.:           :|.||..:|....|:::
  Rat  1808 VFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLVTVLI 1872

  Fly  1196 EHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEID-DCAREEKRVTDLIKDPLNDHSLIVHN 1259
            ::::             |.|.: .....||  |:::.| |..||.:|:  |.....|| .|.:..
  Rat  1873 QYRF-------------FIRPR-PVKARLP--PLNDEDEDVRRERQRI--LEGGGQND-ILEIKE 1918

  Fly  1260 LRKRYGDKL--AVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHE 1322
            |.|.|..|.  |||.:......||||||||||||||||||:|:..:..:..|...:....|..:.
  Rat  1919 LTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKTSTFKMLTGDTAVTRGDALLNKNSILSNI 1983

  Fly  1323 LKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQK 1386
            .:..:..|||||:||:.:.:|..:.|.:.|||||:..:...       .|..| :.|:.|.||.:
  Rat  1984 HEVHQNMGYCPQFDAITELLTGREHLEFFALLRGVPEKEVG-------KVGEWAIRKLGLVKYGE 2041

  Fly  1387 VQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSM 1451
            ....:||||.||||..|:|:||.|.:|.|||||||:||.:|||||.|......:.|:||||||||
  Rat  2042 KYASNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSM 2106

  Fly  1452 DECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGL 1514
            :|||.||.|:|||.:|:|:||.::..||..  .|:||.:::.........|....|.   .|||.
  Rat  2107 EECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGL---AFPGS 2168

  Fly  1515 ELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKS 1579
            .|:|.|...|.|.:.:..|.:  :.:|.|..:   .:....:.||||::.||:.:|:.|   ||.
  Rat  2169 VLKEKHRNMLQYQLPSSLSSL--ARIFSILSQ---SKKRLHIEDYSVSQTTLDQVFVNF---AKD 2225

  Fly  1580 QS 1581
            ||
  Rat  2226 QS 2227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	39/157 (25%)
		CcmA	460..767	CDD:224054	110/355 (31%)
		ABC_subfamily_A	461..679	CDD:213230	82/221 (37%)
		ABC2_membrane_3	<937..1117	CDD:289468	42/203 (21%)
		ABC_subfamily_A	1255..1479	CDD:213230	100/226 (44%)
		drrA	1262..1573	CDD:130256	123/315 (39%)
Abca1	XP_038965774.1	rim_protein	1..2238	CDD:130324	473/1887 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.760