DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca4

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001101191.1	Gene:	Abca4 / 310836	RGDID:	1309445	Length:	2290	Species:	Rattus norvegicus

Alignment Length:	1759	Identity:	456/1759 - (25%)
Similarity:	746/1759 - (42%)	Gaps:	453/1759 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 IDDDDYIRSGFLSLQHILDKQYMKYQELGK-DFEVVVSSMPNMEVISMDSHRLTYFGTLCSILFN 232
            ::|..||..||..||.::::..::.|...: ...|.:..||....:. ||..:..  ..|..:|.
  Rat   579 VEDFRYIWGGFAYLQDMVEQGIVRSQTPAEPPIGVYLQQMPYPCFVD-DSFMIIL--NRCFPIFM 640

  Fly   233 VVL----LSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVVAYLYKA 293
            |:.    :|..|...|.||:..|||.|......:.:...|:||..|...: :.||:|.:..::..
  Rat   641 VLAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMS-MSIFLLTLFIMHGR 704

  Fly   294 LGSICFAYVAVLFLL----------YILST-MSYAYLISICFHSVFYAKIGGLAMLIIPYAFSF- 346
            :......::..||||          ::.|| .|.|.|.:.|...:::.       |.:|:...|
  Rat   705 ILHYSDPFILFLFLLAFATATIMQCFLFSTFFSKASLAAACSGVIYFT-------LYLPHILCFA 762

  Fly   347 --------VRSWATSLAFVCFSTNT-FL-----EGLDIFQTFSNKRKNREFGAVDVFRVIKSNSS 397
                    :::..:.|:.|.|...| :|     :||.:  .:||..|:...|  |.|       |
  Rat   763 WQDRMTADLKTTVSLLSPVAFGFGTEYLVRFEEQGLGL--QWSNIGKSPLEG--DEF-------S 816

  Fly   398 TMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFL------------------------ 438
            .:.|:.::|: .:.||.:|..||..||||..|...|.:|.|
  Rat   817 FLLSMKMMLL-DAALYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP 880

  Fly   439 ------DPK----TYMKRQRNEYTTTPRGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEIT 493
                  ||:    ::.:|:      .|.....:.:..|.|.|:...|..:  |.||:|....:||
  Rat   881 LTEEIEDPEYPEDSFFERE------LPGLVPGVCVKNLVKVFEPGSRPAV--DRLNITFYENQIT 937

  Fly   494 VLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHL 555
            ..||||||||||.::::.||:|..||.:::..   |..:.:.|..:|.||||::...::|..:|:
  Rat   938 AFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDIEISLDAVRQSLGMCPQHNILFHHLTVAEHI 1002

  Fly   556 EFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPS 620
            .|:|||:|....:||...:..|:..||..||||..::|||||:|:||:.||..|::|:|:||||:
  Rat  1003 LFYAQLKGRSWEEARLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPT 1067

  Fly   621 SGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIG 685
            ||:|..|||.:||:||..|..:.::::||:|:||::|||.|.|::.|:|...|:||.||...|.|
  Rat  1068 SGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTG 1132

  Fly   686 YRLKL-------------------------------EINDFTSREV------EIMEIIHHFVPTA 713
            :.|.|                               .:::.|..:|      |:.::::|.||.|
  Rat  1133 FYLTLVRKMKNIQSQRCGCEGACSCTSKGFSARCPARVDEITEEQVLDGDVKELTDLVYHHVPEA 1197

  Fly   714 RVLNVVNPTVYICLPYAYKN----CFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQD- 773
            :::..:...:...||  .||    .:|.:...||....:||:.:..::||.||::||:...:.:
  Rat  1198 KLVECIGQELIFLLP--NKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSES 1260

  Fly   774 -----------------------------------------QVDTPDGSRNDAP----------- 786
                                                     |||.|.|..:..|
  Rat  1261 GSKFVGGTQQKREHTGLRHPCSAPVEKHRQHAQASHTCSPGQVDPPKGQPSPEPEDPGIPFNTGA 1325

  Fly   787 --LLAHYKRLQDHPPHRGLFQLWMAVFYKKWTFISN-----EWLYTLIMLCIPFVCVFGAI--LV 842
              :|.|.:.|.....|.       ||..:| .|::.     .:::..:||.| .|..||..  |.
  Rat  1326 RLILQHVQALLVKRFHH-------AVRSRK-DFVAQIVLPATFVFLALMLSI-IVPPFGEFPALT 1381

  Fly   843 MH-----------AMSLVENE--EAL-PLKLSQMGSGVIYVHN------PTGHH----------- 876
            :|           :|....||  |.| .:.|::.|.|...:..      |.|:.
  Rat  1382 LHPWMYGHQFTFFSMDEPNNEHLEVLADVLLNRPGFGNRCLKEEWLPEYPCGNATSWKTPSVSPN 1446

  Fly   877 -AHLEQQ---------------LRQQI-------ELNGITAKTMHLRGSNDVKNESLDLQRDNLA 918
             .||.|:               .|:::       |..|.......::.|.:|..   ||...|::
  Rat  1447 ITHLFQKQKWTAAHPSPACKCSTREKLIMLPECPEGAGGLPPPQRIQRSTEVLQ---DLTNRNIS 1508

  Fly   919 DFL---------------------------------------EQVIGIIDMYG------GGRGTS 938
            |:|                                       |.::|.:...|      ||..|.
  Rat  1509 DYLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPDIPISGEALVGFLSDLGQMMNVSGGPVTR 1573

  Fly   939 DT--------------PTIEIFYSGNRYHSSVELINLVDSAMLKLGRPE----SEIDTTYV--PI 983
            ::              ..|:::::...:|:.|..:|:..:|:|:...|:    .|...|.:  |:
  Rat  1574 ESSREMLDFLKHLETKDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRDPEEYGITVISQPL 1638

  Fly   984 ---RRFVSDISPSRLEYYAVI---VPIGMFFFMFYFISLPFREYANGFKQLQTMSRF---TYWFA 1039
               :..:|:|:.......||:   |...|.|....|:....:|.....|.||.:|..   |||..
  Rat  1639 NLTKEQLSEITVLTTSIDAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWMT 1703

  Fly  1040 HFTFDML---ILIFVCVALFSLQSLMMPSELYT-TAELKVIVLSIFFYGCSYLPILYALGNNFKS 1100
            :|.:|::   :...:.|.:|    :....:.|| |..|..:|..:..||.:.:|::|.....|..
  Rat  1704 NFLWDIMNYAVSAGLVVGIF----IGFQKKAYTSTDNLPALVTLLMLYGWAVIPMMYPASFLFDV 1764

  Fly  1101 ISTISTYLLLMLIVSAIAPLITSSNAAA----MKLHETKIAFLCFLPDFNLNHQFRIINENFITR 1161
            .||  .|:.|     :.|.|....|::|    ::|.|.....|.|         ...:.|..|..
  Rat  1765 PST--AYVAL-----SCANLFIGINSSAITFVLELFENNRMLLRF---------SATLRELLIVF 1813

  Fly  1162 RHPALIKGLI----SQDTFFAYA--------------------TAVGVMVMAFF--TIVLEHKYL 1200
            .|..|.:|||    ||.....||                    .|:.:..:.:|  |::::|.:.
  Rat  1814 PHFCLGRGLIDLALSQAVTDIYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLLIQHHFF 1878

  Fly  1201 RRRIHDGIWEWAFQRKKYNSTGTLPSTPI-SEIDDCAREEKRV------TDLIKDPLNDHSLIVH 1258
            ..|       |..:..:         .|: .|.||.|.|.:||      :|::|  ||:
  Rat  1879 LTR-------WIAEPAR---------EPVFDEDDDVAEERQRVMSGGSKSDILK--LNE------ 1919

  Fly  1259 NLRKRY--GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREH 1321
             |.|.|  ....|||.:......|||||||||||||||:||:|:..:..:..|...|.|..|..:
  Rat  1920 -LTKVYSGSSSPAVDRLCVGVHPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATIAGKSILTN 1983

  Fly  1322 ELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQ 1385
            .....:..|||||:||::..:|..:.||..|.|||:       |:...|.|..| ::.:.|:.|.
  Rat  1984 ISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGV-------PSKEIEKVANWGIQSLGLSLYA 2041

  Fly  1386 KVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHS 1450
            ......||||.||||..|:|:.|.|.|:||||||||:||.:||.||..|.:...:.|.|||||||
  Rat  2042 DRLAGTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDPQARRMLWNTIVNIIRQGRAVVLTSHS 2106

  Fly  1451 MDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEM-NVSTITGTLKSEFP 1512
            |:|||.||.|||||..|.|:|:..|..||..  .|:.:.:|:|:..:..: :::.:....:..||
  Rat  2107 MEECEALCTRLAIMVKGTFQCMGTIQHLKYKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFP 2171

  Fly  1513 GLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREA 1577
            |...||.|...|.:.|.:       ||:.:|.:..:..:.|.|:.:|||.:.||:.:|:.|   |
  Rat  2172 GSVQRERHHSMLQFQVPS-------SSLARIFQLLISHKDSLLIEEYSVTQTTLDQVFVNF---A 2226

  Fly  1578 KSQS 1581
            |.|:
  Rat  2227 KQQT 2230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	34/161 (21%)
		CcmA	460..767	CDD:224054	118/350 (34%)
		ABC_subfamily_A	461..679	CDD:213230	91/220 (41%)
		ABC2_membrane_3	<937..1117	CDD:289468	45/212 (21%)
		ABC_subfamily_A	1255..1479	CDD:213230	99/226 (44%)
		drrA	1262..1573	CDD:130256	122/316 (39%)
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	456/1759 (26%)
		ABC_subfamily_A	907..1126	CDD:213230	91/220 (41%)
		ABC_subfamily_A	1915..2135	CDD:213230	102/235 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.660