DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca8a

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001268753.1	Gene:	Abca8a / 303638	RGDID:	1307333	Length:	1615	Species:	Rattus norvegicus

Alignment Length:	1750	Identity:	442/1750 - (25%)
Similarity:	746/1750 - (42%)	Gaps:	354/1750 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FVFLRKNLL---YLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPG 71
            :..|.||||   .|:|:.|..||..:.....|:.:..      ||.:.:|.:.:::.|..:....
  Rat    13 WALLCKNLLRKKRLKRDTLWELLYTAFILLCLSLFFE------LHDVYEFSSLSDVDLGRVDSFN 71

  Fly    72 NELDYIYYSPISPNVEDIMDLLRVDL-GIIPER---LRPN-NNSFEMQLEMEQQCRGSCF--AID 129
            :....|.|:|::|..::||:  ||.| ..:..|   ..|| .|..|...:......|..|  |..
  Rat    72 DSTFAIAYTPVTPTTQEIMN--RVSLVSYMTGREILAFPNKENMTEFISKHYDDAVGIIFSTAYS 134

  Fly   130 FH-------RVP--NRGSDRK---FRYSLSSNQMRISPRKRFVNDEEIYHQIDDDDYIRSGFLSL 182
            :|       |:|  ....|..   |||     :..||              .|...:.|.||::|
  Rat   135 YHLKFMKGTRIPIIKEHQDHTAHCFRY-----EPAIS--------------CDLSAFWRHGFVAL 180

  Fly   183 QHILDKQYMKYQELGKDFEVVVSSMP-NMEVISMDSH------RLTYFGTLCSILFNVVLLSSFV 240
            |..::...:   |:..:..|:...|. ..:.|.:||.      ...||..||.|.|:.  |:.::
  Rat   181 QAAINSAII---EVTTNHSVMEEMMSLTGKYIKIDSFIAQEGTTTDYFLFLCIIAFSP--LTYYI 240

  Fly   241 VPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVVAYLYKALGSICFAYVAVL 305
            ...|..::..:|.|:.::........|::.|:..|...::.:|:..|.|..:.:....|..:..|
  Rat   241 SAGVTRERKKMKAFMTVMGLRDSAFWLSWGLLYGVIVFIVTLFLTFVVYSVQFVFMTGFMMIFSL 305

  Fly   306 FLLYILSTMSYAYLISICFHS-------VFYAKIG----GLAML--IIPYAFSFVRSWATSLAFV 357
            |..|.||.:|.::|:|:....       ||:..:.    |.|.|  .:|.:..::.|..:..||:
  Rat   306 FFFYGLSLISLSFLMSVLLKKSFLTDLVVFFLTVSCGSLGFAALYRYLPVSLEWLLSLLSPFAFM 370

  Fly   358 CFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGC 422
            ...|.......|:      :......|          |.:.:.:...:|.|....|.||..|...
  Rat   371 LGMTQLLRLDYDL------ESSGHPTG----------NPNVVIATVFLLFFDGVFYLMLTFYFEK 419

  Fly   423 VFPGPGGLKRPMFFFL--------DP--KTYMKRQRN-EY--------TTTPRGTHAIIITELCK 468
            |.||..|.:.|..|||        :|  :|.:..:|: |:        :|...|...|.|..|.|
  Rat   420 VLPGEYGRRHPPLFFLKSSFWTGQNPADRTVLDNERDYEFPDDSFEPVSTDFHGKEVIRIRNLTK 484

  Fly   469 KF-QTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCSER----- 527
            :: |.|||...:.| |.:.:...:||.:|||:||||:|::|::.||.....|.:.:...:
  Rat   485 EYIQRSKRTEALKD-LTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHDNKLSEMT 548

  Fly   528 DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKN 592
            |:.|...|.|.|||.:|...::|..::|..||:::|....|  :.....|..|.:.:.:|...:|
  Rat   549 DLESISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQEVD--NEVQRVLLALEMKNIQNTLVQN 611

  Fly   593 LSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVL 657
            ||||.||:|:.||||.|:.:|.:||||::|||..||..:|::|...:.::.||.:|.:|:||::|
  Rat   612 LSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNLLKERKADRVVLFSTQFMDEADIL 676

  Fly   658 GDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTARVLNVVNPT 722
            .|....::.|||:..||.|.||:|.||||.|.|::::....| .|..::...:|.:::.......
  Rat   677 ADRKVFISQGKLRCAGSSLFLKKKWGIGYHLSLQLSETCVHE-RITSLVKQHIPDSKLSAESEGK 740

  Fly   723 VYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAG----EQDQVDTPD---- 779
            :...||....|.|.. |||......:|||....::.|:|.:|||:..|    :.|..:|.|
  Rat   741 LNYILPLERTNKFPD-LYRDLERCPDLGIENYGVSVTTLTEVFLKLEGKSAIDSDIGETEDVQAG 804

  Fly   780 GSRNDAPLLAH--YKRLQDHPPHRGLFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILV 842
            |:|....|...  ...|.:....:|...||       |.           .||        |:..
  Rat   805 GTRGPGRLDGEQFVSLLNEMSKTKGGMALW-------WQ-----------QLC--------AVTR 843

  Fly   843 MHAMSLVENEEALPLKLSQMGSGVIYVHNPTGH--------------HAH-LEQQLRQQIELNG- 891
            :..:.|....:::.:.:..:|.|::::.:...|              |.: |....|.|:.|..
  Rat   844 LRFLKLKYRRKSIVILILILGIGLLHILSANVHRLVNQSDYCWELSPHTYFLTPGQRPQMPLTNL 908

  Fly   892 -ITAKTMHLRGSNDVKNESLD-----LQRDNLADFLEQVIGIIDMYGGGRGTSDTPTIEIFYSG- 949
             |..||          .|.:|     |::.|:|  ||     :|.:|...||.|:.     |:|
  Rat   909 LIINKT----------GEKIDDFLHSLEQQNIA--LE-----VDAFGTRNGTEDSQ-----YNGA 951

  Fly   950 ------------------NRYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLE 996
                              .|.:....|:::|.:|:|.|..|...|.|..   ..|..|...:  :
  Rat   952 IIVAGGEKNYNFTLACNTKRLNCFPVLVDIVSNALLGLFTPSVHIQTDR---SSFPEDTGYT--Q 1011

  Fly   997 YYAVIVPIGMFFFMFYFISL-----PF------REYANGFKQLQT----MSRFTYWFAHFTFDM- 1045
            :|.::       :||.:|.|     |:      .:|.|. .|.|.    :|...|||.|..|::
  Rat  1012 FYHLL-------YMFSWILLMACVPPYISMTSIDDYKNR-AQFQLWISGLSPSAYWFGHALFEIP 1068

  Fly  1046 ----LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALG--------NN- 1097
                |||.......||..    |..:.||.:|.:.:|....|..|.:.::|.:.        |:
  Rat  1069 VYSALILSVYIAFYFSAP----PESMITTRDLFIQILYAGGYAMSVIFMMYVISFICRKGRKNSG 1129

  Fly  1098 -----FKSISTISTYLLLM------LIVSAIA--PLITSSNAAAMKLHETKIAFLCFLPDFNLNH 1149
                 |..:|.||..|:|.      .:.|:||  |::|...              |.|..|. ||
  Rat  1130 IWSLCFYIVSFISLCLMLFKFFEDTFLFSSIALIPVVTLVG--------------CTLLHFQ-NH 1179

  Fly  1150 QFRIIN---ENFITRRHPALIKGLISQDTFFAYATAVGVMVMAFFTIVLEHKY-LRRRIHDGIWE 1210
            :|..|:   |.:.|.        |.....||.:      ::..|....||.|: ::....|.::.
  Rat  1180 EFPEISLYPERYYTY--------LFFLAPFFHF------LIFLFILRCLERKFGMKTMRMDPVFR 1230

  Fly  1211 WAFQRKK-YNSTGTLPSTPISEIDDCAREEKRV------TDLIKDPLNDHSLIVHNLRKRY---- 1264
            .:.:..: :|:    |..|..|.:|.:.|..|.      .|..:.|:    :|...|||.|
  Rat  1231 ISSRSDRVFNN----PEEPEGEDEDVSLERVRTANALTSADFQEKPV----IIASCLRKEYKGKK 1287

  Fly  1265 -------GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHE 1322
                   ..|:|...:|....:||..||||.|||||:::.:||...:....|.:::||....:..
  Rat  1288 KCFVLKGKKKIATRNISLCVRKGEVVGLLGHNGAGKSTSIKMITGEIKPSAGQVQLKGNSTGDTP 1352

  Fly  1323 LKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKV 1387
                |:.|||||.:||.:.||..:.|...|.::|:|  ::|...:    :....:.:.|....|.
  Rat  1353 ----EFLGYCPQENALWQHMTVREHLEIFAAIKGMS--KSDAAVA----IARLADALKLQDQLKS 1407

  Fly  1388 QVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIK-DFQGKDRTVVLTSHSM 1451
            .|:..|.|.||||...::::|.|::||||||:||:||..::.:||.|: .|...:|..:||:|.|
  Rat  1408 PVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFANTERGALLTTHYM 1472

  Fly  1452 DECEELCNRLAIMAHGKFKCLNNICALKRLSGFTIKLKMKADTETEMNVSTITGTLKSEFPGLEL 1516
            .|.|.:|:|:|||..||.:|:.:|..||...|....|:||..|.|:  |..:...:...||....
  Rat  1473 AEAEAVCDRVAIMVSGKLRCIGSIQHLKSKFGKEYLLEMKVKTPTQ--VEPLNMEIMRLFPQAAR 1535

  Fly  1517 RESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFERE 1576
            :|.::..:.|.:..::...|..:.||:...    :.|..:.:||:::.|||.:||:..:|
  Rat  1536 QERYSSLMVYKLPREDVQPLSQAFFKLETV----KQSFDLEEYSLSQSTLEQVFLELSKE 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	34/156 (22%)
		CcmA	460..767	CDD:224054	106/312 (34%)
		ABC_subfamily_A	461..679	CDD:213230	80/223 (36%)
		ABC2_membrane_3	<937..1117	CDD:289468	52/238 (22%)
		ABC_subfamily_A	1255..1479	CDD:213230	80/235 (34%)
		drrA	1262..1573	CDD:130256	101/322 (31%)
Abca8a	NP_001268753.1	ABC2_membrane_3	27..416	CDD:289468	90/436 (21%)
		DUF4149	267..354	CDD:290390	20/86 (23%)
		ABC_subfamily_A	477..698	CDD:213230	80/223 (36%)
		drrA	493..787	CDD:130256	99/298 (33%)
		ABC2_membrane_3	<1005..1155	CDD:289468	37/163 (23%)
		CcmA	1272..1591	CDD:224054	105/338 (31%)
		ABC_subfamily_A	1279..1500	CDD:213230	79/230 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750