Protein Alignment Eato and Abca3

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_006246101.1
• Gene: Abca3 / 302973
• RGDID: 1307174
• Length: 1704
• Species: Rattus norvegicus
• Alignment Length: 1756
• Identity: 509/1756 - (28%)
• Similarity: 795/1756 - (45%)
• Gaps: 279/1756 - (15%)

  Fly    14 RKNLLYLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRE-------LYF-- 69
            ||.|:.:....||||     |:|:|.    |    :..:|......|..|..:       |:|
  Rat    20 RKVLVTVLELFLPLL-----FSGILI----W----LRLKIQSENVPNATVYPDQHIQELPLFFSF 71

  Fly    70 --PGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLR--PNNNSFEMQLEMEQQCRGSCFAIDF 130
              ||...:..|....|.....|.:.:|.:. :|..|:.  .:...||..:..:........|:.|
  Rat    72 PPPGGSWELAYVPSHSDAARTITEAVRREF-MIKMRVHGFSSEKDFEDYVRYDNHSSNVLAAVVF 135

  Fly   131 HRVPNRGSD---------RKFRYSLSSNQMRISPRKRFVNDEEIYHQID---------------- 170
            ....|...|         .:|.|: ..|.|.......|:.:.|.:|...
  Rat   136 EHTFNHSKDPLPLAVRYHLRFSYT-RRNYMWTQTGNLFLKETEGWHTASLFPLFPSPGPREPSSP 199

  Fly   171 ---DDDYIRSGFLSLQHILDKQYMKY------QELGKDFEVVVSSMPNMEVISMDSHRLTYFGTL 226
               :..|||.|||::||.:||..|.|      .:|.:...|:....|....|| |..       |
  Rat   200 DGGEPGYIREGFLAVQHAVDKAIMHYHANASAHQLFQKLTVITKRFPFPPYIS-DPF-------L 256

  Fly   227 CSILFN--VVLLSSF-------VVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMI 282
            .:|.:.  ::|:.||       :...|:||:..|||::.::...|:|:...:||: |:.::|:::
  Rat   257 IAIQYQLPLLLMLSFTYTSLTIIRAVVQEKEKKLKEYMRMMGLSSWLHWSAWFLM-FLLFSLIVV 320

  Fly   283 FVLVVAYLYKALGSICF------AYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLAMLI- 339
            ..:.:.:..|....|..      :.|....|.:.:|::|:::::|..|... ..|.:||.....
  Rat   321 SFMTLLFCVKVKKDIAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFFSKANMAATVGGFLYFFT 385

  Fly   340 -IPYAFSFVR-SWAT--SLAFVCFSTNTFLE-GLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTM 399
             .||.|...| :|.|  .....|..:|..:. |..:...|..|....::  .|:...:..:....
  Rat   386 YTPYFFVAPRYNWMTLSQKLLSCLLSNVAMAMGAQLIGKFEAKGTGIQW--CDLLNPVNVDDDFC 448

  Fly   400 F-SVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFL-------DPKTYMKRQ--------- 447
            | .|..:|:..|.||.::..|:..||||..|:.:|.:|||       :|:|.:.::
  Rat   449 FGQVLGMLLLDSVLYGLVTWYVEAVFPGQFGVPQPWYFFLMPSYWCGNPRTVVGKEEEGGDPEKA 513

  Fly   448 -RNEY-TTTPRGTHA-IIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNM 509
             |.|| ...|....| |.|..|.|.||...:|.:...:|.:.:...:||||||||||||||.|:|
  Rat   514 FRTEYFEAEPEDLAAGIKIKHLSKVFQVGNKDKMGIRDLTLNLYEGQITVLLGHNGAGKTTTMSM 578

  Fly   510 IMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARD 571
            :.||.|..||...:..   .:|:...|..:|.||||.|....:|..:||.|:|||:|.......:
  Rat   579 LTGLFPPTSGHAYIRGYEISQDMVQIRKSLGLCPQHDVLFDNLTVAEHLYFYAQLKGLSVQKCPE 643

  Fly   572 WADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILL 636
            ...:.|..|||.|||:...|.|||||||:|::|||:...:|:::||||:||:|..|||.:||:|.
  Rat   644 EVKQMLHTLGLEDKRDSRSKFLSGGMKRKLAIGIALIAGSKVLMLDEPTSGMDAVSRRAIWDLLQ 708

  Fly   637 NLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVE 701
            ..:.::.||:|||:|:||::|||.|.|||.|:||..||.|.||:|.|.||.:.|......:.| .
  Rat   709 QQKSDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPE-G 772

  Fly   702 IMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFL 766
            |.:::||.||.|.:.:.....:...||....:.|..:..:||.:.|||||.:...:.|::|:|||
  Rat   773 ISQLVHHHVPNAMLESHAGAELSFILPKESTHRFESLFAKLEKKQKELGIASFGASVTTMEEVFL 837

  Fly   767 RCAGEQDQVDTP-DGSRNDAPLL--AHYKRLQD----------HPPHRGL--------------- 803
            |..   ..|||. |......|.|  .|.:|..|          ..|..|:
  Rat   838 RVG---KLVDTSMDIQAIQLPALQYQHERRASDWALDSNLCGVMDPTNGIGALIEEEEVLVKLNT 899

  Fly   804 ------FQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQM 862
                  .|.| |:|.||..:...||......:.:|..|:..|:|.::..|.:.::..|.|.|::.
  Rat   900 GLALHCQQFW-AMFLKKAAYSWREWRMVAAQILVPVTCLTLALLAINYTSEIFDDPPLKLSLNEY 963

  Fly   863 GSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVIGI 927
            |:.|:....|  ..:.|.|||.:            |||   |:........|:.|.|..|.::..
  Rat   964 GTTVVPFSVP--GTSRLGQQLSE------------HLR---DMLQAERQEPREVLGDLEEFLVFR 1011

  Fly   928 IDMYGGG-----------RGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKL--GRPESEIDTT 979
            ..:.|||           :.:.:...:...::...|||....:.:||:.:.||  | |.:.|:.:
  Rat  1012 ASVEGGGFNERCLVATSFKDSGERTVVTALFNNQAYHSPATALAIVDNLLFKLLCG-PRASIEIS 1075

  Fly   980 YVPIRRFVSDISPSRLEY------YAVIVPIGMFFFMFYFISLPFREYANGFKQLQTMSRF---T 1035
            ..|..|....::..:...      .|:.:.|.|.|....|..|...|.|...|.:|.:|..   |
  Rat  1076 NYPQPRSTLQVAKDQFNEGRKGFDIALNLLIAMAFLASTFSILAVSERAVQAKHVQFVSGVHVAT 1140

  Fly  1036 YWFAHFTFDML------ILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYAL 1094
            :|.:...:|::      :|:.|....|.:.:......:   |:|   :|.:..||.:.:|::|.|
  Rat  1141 FWLSALLWDLISFLVPSLLLLVVFRAFDVHAFTRDGHM---ADL---LLLLMLYGWAIIPLMYLL 1199

  Fly  1095 GNNFKSISTISTYLLLMLIVSAIAP--LITSSNAAAMKLHE---TKIAFLCFLPDFNLNHQFRII 1154
            ...|.:.||..|.|.:..|:|.||.  ::|.....|:||.|   |.......||:..|.......
  Rat  1200 SFFFSAASTAYTRLTIFNILSGIATFIVVTIMRIPAVKLEELSRTLDHVFLVLPNHCLGMAVSNF 1264

  Fly  1155 NENFITRR---------HPALIKGLISQDTFFAYAT-AVGVMVMA-------FFTI--VLEHKYL 1200
            .||:.|||         |......:..|:.|:|::| .:|..|.:       :.|:  ::|...|
  Rat  1265 YENYETRRYCTSSEVATHYCKKYNIQYQENFYAWSTPGIGKFVTSMAASGGIYLTLLFLIETNLL 1329

  Fly  1201 ----------RRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDPLNDHSL 1255
                      |||     |..|   :..|.|..||     |..|.|.|..||.....|.:.|..|
  Rat  1330 WRLRTFVCAFRRR-----WTLA---ELQNRTSVLP-----EDQDVADERSRVLVPSLDSMLDTPL 1381

  Fly  1256 IVHNLRKRYGDK---LAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGAD 1317
            |::.|.|.|..:   ||||.:|.|..:||||||||.||||||:||:|:.....:..|...:.|..
  Rat  1382 IINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNGAGKTTTFKMLTGEETITSGDAFVGGYS 1446

  Fly  1318 IREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLT 1382
            |.....|.|:..|||||:|||...||..:.|...|.|||:..|..|   :|.|:.   |..:.|.
  Rat  1447 ISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRGIPERLID---ACVENT---LRGLLLE 1505

  Fly  1383 KYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLT 1447
            .:....|:.||||.||||...:|:||.||::.||||:||:||::||.||..:...:...:.:|:|
  Rat  1506 PHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIVIT 1570

  Fly  1448 SHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSE 1510
            ||||:|||.||.|||||..|:||||.:...||..  ||::::.|::::.:.|: :......:...
  Rat  1571 SHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLQAKVRSEGKQEV-LEEFKAFVDLT 1634

  Fly  1511 FPGLELRESHAGTLTYFVSTQESVVLWSSVFKI---AEEYLGDRLSALVADYSVNECTLEDIFLK 1572
            |||..|.:.|...:.|.:...:  :.|:.||.|   |:|..|      |.||||::.:||.:||.
  Rat  1635 FPGSVLEDEHQDMVHYHLPGCD--LSWAKVFGILEKAKEKYG------VDDYSVSQISLEQVFLS 1691

  Fly  1573 F 1573
            |
  Rat  1692 F 1692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	34/155 (22%)
		CcmA	460..767	CDD:224054	128/310 (41%)
		ABC_subfamily_A	461..679	CDD:213230	99/220 (45%)
		ABC2_membrane_3	<937..1117	CDD:289468	44/196 (22%)
		ABC_subfamily_A	1255..1479	CDD:213230	101/226 (45%)
		drrA	1262..1573	CDD:130256	126/318 (40%)
Abca3	XP_006246101.1	rim_protein	<206..1699	CDD:130324	472/1555 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860